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Source: Circulation Research

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Total 159 results found since Jan 2013.

Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
Conclusions: Ischemic stroke activates hematopoietic stem cells via increased sympathetic tone, leading to a myeloid bias of hematopoiesis and higher bone marrow output of inflammatory Ly6Chigh monocytes. PMID: 25362208 [PubMed - as supplied by publisher]
Source: Circulation Research - October 31, 2014 Category: Cardiology Authors: Courties G, Herisson F, Sager H, Heidt T, Ye Y, Ying W, Sun Y, Severe N, Dutta P, Scharff J, Scadden D, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Tags: Circ Res Source Type: research

Esm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability.
Conclusions: Esm1 is simultaneously a target and modulator of VEGF signaling in endothelial cells, playing a role in angiogenesis, inflammation and vascular permeability, which might be of potential interest for therapeutic applications. PMID: 25057127 [PubMed - as supplied by publisher]
Source: Circulation Research - July 23, 2014 Category: Cardiology Authors: Rocha SF, Schiller M, Jing D, Li H, Butz S, Vestweber D, Biljes D, Drexler HC, Nieminen-Kelha M, Vajkoczy P, Adams S, Benedito R, Adams RH Tags: Circ Res Source Type: research

Mechanisms of plaque formation and rupture.
Abstract Atherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), or lower extremities (peripheral vascular disease). The most common of these manifestations is coronary heart disease, including stable angina pectoris and the acute coronary syndromes. Atherosclerosis is a lipoprotein-driven disease that leads to plaque formation at specific sites of the arterial tree through intimal inflammation, necrosis, fibrosis, and calcification. After decades of indolent progression, such plaques may ...
Source: Circulation Research - June 6, 2014 Category: Cardiology Authors: Bentzon JF, Otsuka F, Virmani R, Falk E Tags: Circ Res Source Type: research

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms.
Abstract Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%-26%). The aim of this article is to review the clinical epidemiological features of AF and to relate them to underlying mechanisms. Long-established risk factors for AF include aging, male sex, hypertension, valve disease, left ventricular dysfunction, obesity, and alcohol consumption. Emerging risk factors include prehypertension, increased pulse pressure, obstructive sleep apnea, high-level physical training, diastolic dysfunction, predisposing gene variants, hypertrophic cardiomyopathy, and congenital heart disease. Po...
Source: Circulation Research - April 25, 2014 Category: Cardiology Authors: Andrade J, Khairy P, Dobrev D, Nattel S Tags: Circ Res Source Type: research

Platelet Immunoreceptor Tyrosine-Based Activation Motif (ITAM) Signaling and Vascular Integrity.
Abstract Platelets are well-known for their critical role in hemostasis, that is, the prevention of blood loss at sites of mechanical vessel injury. Inappropriate platelet activation and adhesion, however, can lead to thrombotic complications, such as myocardial infarction and stroke. To fulfill its role in hemostasis, the platelet is equipped with various G protein-coupled receptors that mediate the response to soluble agonists such as thrombin, ADP, and thromboxane A2. In addition to G protein-coupled receptors, platelets express 3 glycoproteins that belong to the family of immunoreceptor tyrosine-based activati...
Source: Circulation Research - March 28, 2014 Category: Cardiology Authors: Boulaftali Y, Hess PR, Kahn ML, Bergmeier W Tags: Circ Res Source Type: research

Translating Koch's Postulates to Identify Matrix Metalloproteinase Roles in Postmyocardial Infarction Remodeling: Cardiac Metalloproteinase Actions (CarMA) Postulates.
Abstract The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP cardiovascular biology remains observational, with few studies homing in on cause and effect relationships. Koch's postulates were first developed in the 19th century as a way to establish microorganism function and were modified in the 20th century to includ...
Source: Circulation Research - February 28, 2014 Category: Cardiology Authors: Iyer RP, de Castro Brás LE, Jin YF, Lindsey ML Tags: Circ Res Source Type: research

Towards Effective and Safe Thrombolysis and Thromboprophylaxis: Preclinical Testing of a Novel Antibody-Targeted Recombinant Plasminogen Activator Directed Against Activated Platelets.
CONCLUSIONS: Targeting of scuPA to activated GPIIb/IIIa allows effective thrombolysis and the potential novel use as a fibrinolytic agent for thromboprophylaxis without bleeding complications. PMID: 24508759 [PubMed - as supplied by publisher]
Source: Circulation Research - February 9, 2014 Category: Cardiology Authors: Wang X, Palasubramaniam J, Gkanatsas Y, Hohmann JD, Westein E, Kanojia R, Alt K, Huang D, Jia F, Ahrens I, Medcalf RL, Peter K, Hagemeyer CE Tags: Circ Res Source Type: research

CEACAM1: An Adhesion Molecule That Limits Blood-Brain Barrier Damage by Neutrophils After Stroke.
PMID: 24071454 [PubMed - in process]
Source: Circulation Research - September 27, 2013 Category: Cardiology Authors: Sobey CG, Drummond GR Tags: Circ Res Source Type: research

CEACAM1 Inhibits MMP-9-Mediated Blood-Brain-Barrier Breakdown in a Mouse Model for Ischemic Stroke.
Conclusions: CEACAM1 controls MMP-9 secretion by neutrophils in postischemic inflammation at the BBB after stroke. We propose CEACAM1 as an important inhibitory regulator of neutrophil-mediated tissue damage and BBB breakdown in focal cerebral ischemia. PMID: 23780386 [PubMed - as supplied by publisher]
Source: Circulation Research - June 18, 2013 Category: Cardiology Authors: Ludewig P, Sedlacik J, Gelderblom M, Bernreuther C, Korkusuz Y, Wagener C, Gerloff C, Fiehler J, Magnus T, Horst AK Tags: Circ Res Source Type: research