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Source: International Journal of Stroke
Condition: Ischemic Stroke
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Total 291 results found since Jan 2013.
Safety of intravenous thrombolysis for acute ischemic stroke in patients with preexisting intracranial neoplasms: a case series
Source: International Journal of Stroke - March 16, 2015 Category: Neurology Authors: Karanbir Singh, Ashkan Mowla, Sandhya Mehla, Mohammad K. Ahmed, Peyman Shirani, Wendy E. Zimmer, Robert N. Sawyer, Haris Kamal, Annemarie Crumlish, Marilou Ching Tags: Letter to the editor Source Type: research
A combination of neostigmine and anisodamine protects against ischemic stroke by activating α7nAChR
ConclusionsCurrent study identified the optimal combination of neostigmine and anisodamine against ischemic stroke, and indicated that the acetylcholine‐α7 nicotinic acetylcholine receptor is involved in the protective effects.
Source: International Journal of Stroke - March 2, 2015 Category: Neurology Authors: Jiao Qian, Jing‐Ming Zhang, Li‐Li Lin, Wen‐Zhe Dong, Yan‐Qiong Cheng, Ding‐Feng Su, Ai‐Jun Liu Tags: Research Source Type: research
Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions
Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microbleeds. It causes a quarter of all ischemic strokes, is the commonest cause of vascular dementia, and the cause is incompletely understood. Vascular prophylaxis, as appropriate for large artery disease and cardioembolism, includes antithrombotics, and blood pressure and lipid lowering; however, these strategies may not be effective for small vessel disease, or are already used routinely so precluding further detailed study. Further, intensive antiplatelet therapy is known to be hazardous in small vessel disease through enhanced...
Source: International Journal of Stroke - February 1, 2015 Category: Neurology Authors: Philip M. Bath, Joanna M. Wardlaw Tags: Review Source Type: research
Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema
Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic thrombolysis for acute ischemic stroke. To understand the paradox of injury caused by treatment, we first emphasize the phenomenon in which recanalization of an occluded artery does not lead to tissue reperfusion. Additionally, no‐reflow after recanalization may be due to injury of the neurovascular unit, distal microthrombosis, or both, and certainly worsens outcome. We examine the mechanism of molecular and subcellular damage in the...
Source: International Journal of Stroke - January 19, 2015 Category: Neurology Authors: Jilin Bai, Patrick D. Lyden Tags: Review Source Type: research
Quadriparesis due to simultaneous occurrence of hemorrhagic and ischemic stroke
Source: International Journal of Stroke - January 19, 2015 Category: Neurology Authors: E. E. Philip‐Ephraim, A. Charidimou, G. A. Kajogbola Tags: Letter to the editor Source Type: research
Carotid plaque inflammation assessed with 18F‐FDG PET/CT is higher in symptomatic compared with asymptomatic patients
Conclusion18F‐FDG uptake on PET/CT correlated with histological assessments of inflammation and was higher in patients with symptomatic compared with asymptomatic carotid artery plaques. These results support the use of 18F‐FDG PET/CT in the detection inflammation in carotid atherosclerosis, which may be of help in the detection of vulnerable plaques.
Source: International Journal of Stroke - January 15, 2015 Category: Neurology Authors: Karolina Skagen, Kjersti Johnsrud, Kristin Evensen, Helge Scott, Kirsten Krohg‐Sørensen, Frode Reier‐Nilsen, Mona‐Elisabeth Revheim, Jan Gunnar Fjeld, Mona Skjelland, David Russell Tags: Research Source Type: research
Stroke incidence and case‐fatality among Indigenous and non‐Indigenous populations in the Northern Territory of Australia, 1999–2011
ConclusionsIn the Northern Territory, as elsewhere in Australia, Indigenous Australians are more likely than other Australians to suffer a stroke. Lack of falling in incidence in the Northern Territory population highlights the importance for ongoing comprehensive primary and acute care in reducing risk factors and managing stroke patients.
Source: International Journal of Stroke - January 15, 2015 Category: Neurology Authors: Jiqiong You, John R. Condon, Yuejen Zhao, Steven L. Guthridge Tags: Research Source Type: research
Trends in oral anticoagulant choice for acute stroke patients with nonvalvular atrial fibrillation in Japan: The SAMURAI‐NVAF Study
ConclusionsWarfarin use at acute hospital discharge was still common in the initial years after approval of nonvitamin K antagonist oral anticoagulants, although nonvitamin K antagonist oral anticoagulant users increased gradually. The index stroke was milder and ischemia‐risk indices were lower in nonvitamin K antagonist oral anticoagulant users than in warfarin users. Early initiation of nonvitamin K antagonist oral anticoagulants seemed safe.
Source: International Journal of Stroke - January 12, 2015 Category: Neurology Authors: Kazunori Toyoda, Shoji Arihiro, Kenichi Todo, Hiroshi Yamagami, Kazumi Kimura, Eisuke Furui, Tadashi Terasaki, Yoshiaki Shiokawa, Kenji Kamiyama, Shunya Takizawa, Satoshi Okuda, Yasushi Okada, Tomoaki Kameda, Yoshinari Nagakane, Yasuhiro Hasegawa, Hiroshi Tags: Research Source Type: research
Modest blood pressure reduction with valsartan in acute ischemic stroke: a prospective, randomized, open‐label, blinded–end‐point trial
ConclusionsEarly reduction of BP with valsartan did not reduce death or dependency and major vascular events at 90 days, but increased the risk of END.
Source: International Journal of Stroke - January 12, 2015 Category: Neurology Authors: Mi Sun Oh, Kyung‐Ho Yu, Keun‐Sik Hong, Dong‐Wha Kang, Jong‐Moo Park, Hee‐Joon Bae, Jaseong Koo, Juneyoung Lee, Byung‐Chul Lee, Tags: Research Source Type: research
Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial
DiscussionThis paper and attachment describe the trial's statistical analysis plan, as developed from the protocol during recruitment and prior to unblinding of data. The statistical analysis plan contains design and methods for analyses, and unpopulated tables and figures for the primary and baseline publications. The data from the trial will provide the first large‐scale randomized evidence for the use of intensive antiplatelet therapy for preventing recurrence after acute stroke and transient ischemic attack.
Source: International Journal of Stroke - December 31, 2014 Category: Neurology Authors: Philip M. W. Bath, Katie Robson, Lisa J. Woodhouse, Nikola Sprigg, Robert Dineen, Stuart Pocock, Tags: Protocol Source Type: research
Imaging of occlusive thrombi in acute ischemic stroke
Thrombi, or clots, often occlude proximal segments of the cerebral arterial circulation in acute ischemic stroke. Thromboembolic occlusion or thrombi superimposed on atherosclerotic plaque are the principal focus of acute stroke therapies such as thrombolysis or thrombectomy. We review the imaging characteristics of thrombi on multimodal computed tomography and magnetic resonance imaging, angiography, and ultrasonography, summarizing recent studies that facilitate therapeutic decision‐making from these noninvasive studies. Information about the location, size, and imaging characteristics can be ascertained using these te...
Source: International Journal of Stroke - December 26, 2014 Category: Neurology Authors: Gregory G. Gasparian, Nerses Sanossian, Mark S. Shiroishi, David S. Liebeskind Tags: Review Source Type: research
Prior antiplatelet agent use and outcomes after intravenous thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke: a meta‐analysis of cohort studies and randomized controlled trials
ConclusionsIn acute ischemic stroke patients receiving intravenous recombinant tissue plasminogen activator therapy, prior antiplatelet agent use did not lead to a significant difference in functional outcome, although it significantly increased the risk of symptomatic intracranial hemorrhage. Recanalization rate was not different between two groups. In the subgroup analysis, prior clopidogrel mono therapy may not increase the risk of symptomatic intracranial hemorrhage, which will need further studies to confirm.
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Xiding Pan, Yubing Zhu, Danni Zheng, Yukai Liu, Feng Yu, Jie Yang Tags: Review Source Type: research
Should minor stroke patients be thrombolyzed? A focused review and future directions
Stroke is a leading cause of morbidity and mortality worldwide. Up to 80% of ischemic stroke patients may initially present with minor symptoms. Minor stroke and transient ischemic attack patients are typically treated conservatively with antiplatelet agents and general vascular prevention strategies. Yet a high proportion develop recurrent stroke or progression of stroke and up to one in four of these patients are disabled or dead at follow‐up. Minor or rapidly improving symptoms are the top reasons for withholding thrombolytic therapy to time‐eligible stroke patients as they are believed to be ‘too good to treat’...
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Amy Y. X. Yu, Michael D. Hill, Shelagh B. Coutts Tags: Review (invited) Source Type: research
Canadian Stroke Best Practice Recommendations: secondary prevention of stroke guidelines, update 2014
Every year, approximately 62 000 people with stroke and transient ischemic attack are treated in Canadian hospitals. The 2014 update of the Canadian Secondary Prevention of Stroke guideline is a comprehensive summary of current evidence‐based recommendations for clinicians in a range of settings, who provide care to patients following stroke. Notable changes in this 5th edition include an emphasis on treating the highest risk patients who present within 48 h of symptom onset with transient or persistent motor or speech symptoms, who need to be transported to the closest emergency department with capacity for advanced...
Source: International Journal of Stroke - December 23, 2014 Category: Neurology Authors: Shelagh B. Coutts, Theodore H. Wein, M. Patrice Lindsay, Brian Buck, Robert Cote, Paul Ellis, Norine Foley, Michael D. Hill, Sharon Jaspers, Albert Y. Jin, Brenda Kwiatkowski, Carolyn MacPhail, Dana McNamara‐Morse, Michael S. McMurtry, Tania Mysak, Andr Tags: Guidelines Source Type: research
Clinical characteristics and outcome of the capsular warning syndrome: a multicenter study
ConclusionsCapsular warning syndrome preceded an ischemic infarction in 71·2% of patients. In addition to the internal capsule, other locations were noted. The most effective treatment remains unclear. The functional prognosis is favorable in most patients and recurrences are rare.
Source: International Journal of Stroke - December 19, 2014 Category: Neurology Authors: Pol Camps‐Renom, Raquel Delgado‐Mederos, Alejandro Martínez‐Domeño, Luís Prats‐Sánchez, Elena Cortés‐Vicente, Manuel Simón‐Talero, Adrià Arboix, Ángel Ois, Francisco Purroy, Joan Martí‐Fàbregas Tags: Research Source Type: research
