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Source: International Journal of Stroke
Condition: Ischemic Stroke
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Total 291 results found since Jan 2013.
Aortic stiffness and plasma brain natriuretic peptide predicts mortality in acute ischemic stroke
ConclusionsAortic stiffness and brain natriuretic peptide predict mortality in patients with first‐ever acute ischemic stroke. Brain natriuretic peptide also differentiates cardioembolic stroke from noncardioembolic stroke.
Source: International Journal of Stroke - May 22, 2013 Category: Neurology Authors: Murat Biteker, Temel Özden, Akın Dayan, Ahmet İlker Tekkeşin, Cemile Handan Mısırlı Tags: Research Source Type: research
Trials of endovascular therapies or collaterals?
Several landmark clinical trials of endovascular therapy for acute ischemic stroke have recently jolted the concerted multidisciplinary efforts to develop effective revascularization strategies. Further consideration of these four endovascular stroke trials published in the last year suggests a more fundamental question: are these trials of specific treatments or have the results simply reflected the importance of underlying pathophysiology? Data from IMS III, MR RESCUE, SWIFT and TREVO2 consistently demonstrate the dramatic impact of collateral perfusion in acute ischemic stroke. Such collateral, or parallel, trials of th...
Source: International Journal of Stroke - May 20, 2013 Category: Neurology Authors: David S. Liebeskind Tags: Leading opinion Source Type: research
What are the most important barriers for thrombolytic therapy in ischemic stroke patients?
Source: International Journal of Stroke - May 20, 2013 Category: Neurology Authors: Hormoz Ayromlou, Hassan Soleimanpour, Mehdi Farhoudi, Elyar Sadeghi‐Hokmabadi, Rouzbeh Rajaei Ghafouri, Ehsan Sharifipour, Somayeh Mostafaei, Mehdi Najafi Nashali Tags: Letter to the editor Source Type: research
Mechanical endovascular therapy in ischaemic stroke: temporal trend of outcomes
Source: International Journal of Stroke - May 20, 2013 Category: Neurology Authors: Valeria Fadda, Dario Maratea, Sabrina Trippoli, Andrea Messori Tags: Letter to the editor Source Type: research
Body temperature, blood infection parameters, and outcome of thrombolysis‐treated ischemic stroke patients
ConclusionA lower level of systemic inflammation at time of thrombolysis may be associated with clinical improvement and good outcome at three‐months. Increase in body temperature during the first 24 h associates with lack of clinical improvement and worse patient outcome.
Source: International Journal of Stroke - April 1, 2013 Category: Neurology Authors: Marjaana Tiainen, Atte Meretoja, Daniel Strbian, Joel Suvanto, Sami Curtze, Perttu J. Lindsberg, Lauri Soinne, Turgut Tatlisumak, Tags: Research Source Type: research
Details of a prospective protocol for a collaborative meta‐analysis of individual participant data from all randomized trials of intravenous rt‐PA vs. control: statistical analysis plan for the Stroke Thrombolysis Trialists’ Collaborative meta‐analysis
We describe the protocol for an updated individual patient data meta‐analysis of trials of intravenous alteplase, including results from the recently reported third International Stroke Trial, in which a wide range of patients enrolled up to six‐hours after stroke onset were randomized to alteplase vs. control.
Study OutcomesThis protocol will specify the primary outcome for efficacy, specified prior to knowledge of the results from the third International Stroke Trial, as the proportion of patients having a ‘favorable’ stroke outcome, defined by modified Rankin Score 0–1 at final follow‐up at three‐ to six...
Source: International Journal of Stroke - April 1, 2013 Category: Neurology Tags: Protocol Source Type: research
Burden of stroke in Estonia
Estonia is the smallest of the three Baltic countries. The decline in incidence of first‐ever stroke during the 1990s has left Tartu, Estonia with a relatively low stroke incidence. However, the incidence rates for younger age groups, and the 28‐day case fatality rate are higher compared with several other studies. Developments in the national health care system in recent years have been positive: the decline of mortality rate of stroke in Estonia is greater than the European Union average. However, the mortality of cardiovascular diseases is higher compared with several European countries. The prevalence of most strok...
Source: International Journal of Stroke - April 1, 2013 Category: Neurology Authors: Janika Kõrv, Riina Vibo Tags: Panorama Source Type: research
Posterior circulation stroke is associated with prolonged door‐to‐needle time
ConclusionsPosterior circulation stroke patients had a delay in neurology evaluation after initial emergency department evaluation and a delay in intravenous tissue plasminogen activator administration compared with anterior circulation stroke patients. There may be difficulties in rapidly recognizing the symptoms of posterior circulation stroke, in contrast to anterior circulation stroke, in the emergency department.
Source: International Journal of Stroke - April 1, 2013 Category: Neurology Authors: Amrou Sarraj, Sarah Medrek, Karen Albright, Sheryl Martin‐Schild, Wafi Bibars, Farhaan Vahidy, James C. Grotta, Sean I. Savitz Tags: Research Source Type: research
Stroke incidence and 30‐day and six‐month case fatality rates in Udine, Italy: a population‐based prospective study
ConclusionsOur study shows incidence rates higher than previously reported in our region but not supporting the view of higher incidence rates in Northern than in Southern Italy. Results contribute to time‐trends analysis on epidemiology, useful for dimensioning services in Italy and show the persistence of a gap between the outcome of stroke in Italy and that of the best performing European countries, urging to adopt better stroke management plans.
Source: International Journal of Stroke - March 21, 2013 Category: Neurology Authors: Francesco Janes, Gian Luigi Gigli, Lucio D'Anna, Iacopo Cancelli, Anna Perelli, Giessica Canal, Valentina Russo, Barbara Zanchettin, Mariarosaria Valente Tags: Research Source Type: research
The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial protocol: a randomized, blinded, efficacy trial of standard vs. intensive hyperglycemia management in acute stroke
DiscussionThis trial will provide important novel information about preferred management of acute ischemic stroke patients with hyperglycemia. It will determine the potential benefits and risks of intensive glucose control during acute stroke.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Askiel Bruno, Valerie L. Durkalski, Christiana E. Hall, Rattan Juneja, William G. Barsan, Scott Janis, William J. Meurer, Amy Fansler, Karen C. Johnston, Tags: Protocol Source Type: research
CHIMES‐I: sub‐group analyzes of the effects of NeuroAiD according to baseline brain imaging characteristics among patients randomized in the CHIMES study
RationaleThe clinical effects of neuroprotective and/or neurorestorative therapies may vary according to location and size of the ischemic injury. Imaging techniques can be useful in stratifying patients for trials that may be beneficial against particular ischemic lesion characteristics.
AimTo test the hypothesis that the efficacy of NeuroAiD compared with placebo in improving functional outcome and reducing neurological deficit in patients with cerebral infarction of intermediate severity varies between sub‐groups of patients randomized in the main Chinese Medicine Neuroaid Efficacy on Stroke study when categorized acc...
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Jose C. Navarro, Christopher Chen Li Hsian, Pedro Danilo J. Lagamayo, Melodia B. Geslani, Gaik Bee Eow, Niphon Poungvarin, Asita Silva, Lawrence K. S. Wong, N. Venketasubramanian, Tags: Protocol Source Type: research
Efficacy and safety of warfarin vs. antiplatelet therapy in patients with systolic heart failure and sinus rhythm: a systematic review and meta‐analysis of randomized controlled trials
ConclusionsWarfarin as compared with antiplatelet therapy reduces risk of ischemic stroke, does not significantly affect death, myocardial infarction, hospitalization due to heart failure or intracranial hemorrhage and increases major hemorrhage in heart failure patients who are in sinus rhythm.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Aaron YL. Liew, John W. Eikelboom, Stuart J. Connolly, Martin O' Donnell, Robert G. Hart Tags: Systematic Review Source Type: research
Emergency transfer of acute stroke patients within the East Saxony telemedicine stroke network: a descriptive analysis
ConclusionsA remarkable number of stroke patients can be transferred within a telemedical network to enable the delivery of specific stroke therapies that require advanced multispecialty expertise. Whether associated logistic efforts and costs have an impact on patients' clinical outcomes needs to be evaluated.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Jessica Kepplinger, Imanuel Dzialowski, Kristian Barlinn, Volker Puetz, Claudia Wojciechowski, Hauke Schneider, Georg Gahn, Tobias Back, Gabriele Schackert, Heinz Reichmann, Ruediger Kummer, Ulf Bodechtel Tags: Research Source Type: research
Door‐to‐door survey of cardiovascular health, stroke, and ischemic heart disease in rural coastal Ecuador – the Atahualpa Project: methodology and operational definitions
DiscussionImplementation of public health strategies directed to improve the cardiovascular health status of a given population must be based on studies evaluating specific risk factors at regional levels. Epidemiologic surveys such as the Atahualpa Project may prove cost‐effective in improving the cardiovascular health status of people living in Latin American rural villages by increasing the knowledge on the particular needs of these populations.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Ernesto Peñaherrera, Elio Ochoa, Milton Santamaría, Mauricio Zambrano, Victor J. Del Brutto, Tags: Protocols Source Type: research
Safety and feasibiLIty of Metformin in patients with Impaired glucose Tolerance and a recent TIA or minor ischemic stroke (LIMIT) trial – a multicenter, randomized, open‐label phase II trial
ConclusionsTreatment with metformin in patients with TIA or minor ischemic stroke and impaired glucose tolerance is safe, but leads to minor side effects. If tolerated, it may lead to a significant reduction in post‐load glucose levels. This suggests that the role of metformin as potential therapeutic agent for secondary stroke prevention should be further explored.
Source: International Journal of Stroke - March 15, 2013 Category: Neurology Authors: Heleen M. Hertog, S. E. Vermeer, A. A. M. Zandbergen, Sefanja Achterberg, Diederik W. J. Dippel, Ale Algra, L. J. Kappelle, Peter J. Koudstaal Tags: Protocols Source Type: research
