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Source: International Journal of Stroke
Condition: Ischemic Stroke

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Total 291 results found since Jan 2013.

Do cerebral microbleeds increase the risk of intracerebral hemorrhage after thrombolysis for acute ischemic stroke?
Source: International Journal of Stroke - March 15, 2013 Category: Neurology Authors: Andreas Charidimou, Zoe Fox, David J. Werring Tags: Letter to the editor Source Type: research

The China Stroke Secondary Prevention Trial (CSSPT) protocol: a double‐blinded, randomized, controlled trial of combined folic acid and B vitamins for secondary prevention of stroke
DiscussionThis is the first multicenter randomized trial of secondary prevention for ischemic stroke in a Chinese population with a higher homocysteine level but without folate food fortification.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Xuedong Liu, Ming Shi, Feng Xia, Junliang Han, Zhirong Liu, Bo Wang, Fang Yang, Li Li, Songdi Wu, Ling Wang, Nan Liu, Yali Lv, Gang Zhao Tags: Protocols Source Type: research

Long‐term mortality in patients with coexisting potential causes of ischemic stroke
ConclusionsCoexisting potential causes of ischemic stroke impact on long‐term mortality. Identification of coexisting potential causes may help to predict stroke outcomes and to guide planning secondary prevention strategies.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Young Dae Kim, Myoung‐Jin Cha, Jinkwon Kim, Dong Hyun Lee, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Ji Hoe Heo Tags: Research Source Type: research

Postthrombolysis outcomes in acute ischemic stroke patients of Asian race‐ethnicity
ConclusionsOur data indicate that Asian patients derive benefit from thrombolytic therapy.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Nishant K. Mishra, Bernard P. L. Chan, Hock‐Luen Teoh, Chang‐Hui Meng, Kennedy R. Lees, Christopher Chen, Vijay K. Sharma, Tags: Research Source Type: research

A multicenter, randomized, double‐blind, placebo‐controlled trial to test efficacy and safety of magnetic resonance imaging‐based thrombolysis in wake‐up stroke (WAKE‐UP)
DiscussionIf positive, WAKE‐UP is expected to change clinical practice making effective and safe treatment available for a large group of acute stroke patients currently excluded from specific acute therapy.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Götz Thomalla, Jochen B. Fiebach, Leif Østergaard, Salvador Pedraza, Vincent Thijs, Norbert Nighoghossian, Pascal Roy, Keith W. Muir, Martin Ebinger, Bastian Cheng, Ivana Galinovic, Tae‐Hee Cho, Josep Puig, Florent Boutitie, Claus Z. Simonsen, Matthia Tags: Protocols Source Type: research

Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation
ConclusionAtrial fibrillation is associated with greater volumes of more severe baseline hypoperfusion, leading to higher infarct growth, more frequent severe hemorrhagic transformation and worse stroke outcomes.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Hans T. H. Tu, Bruce C. V. Campbell, Soren Christensen, Patricia M. Desmond, Deidre A. De Silva, Mark W. Parsons, Leonid Churilov, Maarten G. Lansberg, Michael Mlynash, Jean‐Marc Olivot, Matus Straka, Roland Bammer, Gregory W. Albers, Geoffrey A. Donnan Tags: Research Source Type: research

Dual antiplatelets reduce microembolic signals in patients with transient ischemic attack and minor stroke: subgroup analysis of CLAIR study
ConclusionsEarly dual therapy with clopidogrel and aspirin reduces microembolic signals in patients with minor ischemic stroke or transient ischemic attack, without causing significant bleeding complications.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Alexander Y. Lau, Yudong Zhao, Christopher Chen, Thomas W. Leung, Jianhui Fu, Yining Huang, Nijasri C. Suwanwela, Zhao Han, Kay Sin Tan, Disya Ratanakorn, Hugh S. Markus, Ka Sing Wong, Tags: Clinical Trial Source Type: research

Inflammatory markers and their association with post stroke cognitive decline
ConclusionsFollowing ischemic stroke, higher serum interleukin 8 is independently associated with baseline cognitive impairment while higher serum interleukin 12 is associated with subsequent cognitive decline.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Kaavya Narasimhalu, Jasinda Lee, Yi‐Lin Leong, Lu Ma, Deidre A. De Silva, Meng‐Cheong Wong, Hui‐Meng Chang, Christopher Chen Tags: Research Source Type: research

Referral and triage of patients with transient ischemic attacks to an acute access clinic: risk stratification in an Australian setting
ConclusionsTimes from event to clinic assessment were in excess of current recommendations and risk stratification was suboptimal, though short‐term outcomes were good. Improvements in referral mechanisms may enhance risk‐stratification and triage.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Parker Magin, Daniel Lasserson, Mark Parsons, Neil Spratt, Malcolm Evans, Michelle Russell, Angela Royan, Susan Goode, Patrick McElduff, Christopher Levi Tags: Research Source Type: research

Protocol for the perfusion and angiography imaging sub‐study of the Third International Stroke Trial (IST‐3) of alteplase treatment within six‐hours of acute ischemic stroke
RationaleIntravenous thrombolysis with recombinant tissue Plasminogen Activator improves outcomes in patients treated early after stroke but at the risk of causing intracranial hemorrhage. Restricting recombinant tissue Plasminogen Activator use to patients with evidence of still salvageable tissue, or with definite arterial occlusion, might help reduce risk, increase benefit and identify patients for treatment at late time windows. AimsTo determine if perfusion or angiographic imaging with computed tomography or magnetic resonance help identify patients who are more likely to benefit from recombinant tissue Plasminogen Ac...
Source: International Journal of Stroke - January 22, 2013 Category: Neurology Authors: Joanna M. Wardlaw, Rudiger Kummer, Trevor Carpenter, Mark Parsons, Richard I. Lindley, Geoff Cohen, Veronica Murray, Adam Kobayashi, Andre Peeters, Francesca Chappell, Peter A. G. Sandercock Tags: Protocols Source Type: research

Thrombolysis in the developing world: is there a role for streptokinase?
Intravenous thrombolysis with tissue plasminogen activator is the only proven acute therapy for ischemic stroke. This therapy has not been translated into clinical practice in the developing world primarily due to economic constraints. Streptokinase, a lower cost alternative thrombolytic agent, is widely available in developing countries where it is utilized to treat patients with acute coronary syndromes. Although this drug has previously been found to be ineffective in ischemic stroke, the lack of benefit may have been related to a number of factors related to trial design rather than the drug itself. Specific features o...
Source: International Journal of Stroke - January 21, 2013 Category: Neurology Authors: Ken Butcher, Ashfaq Shuaib, Jeffrey Saver, Geoffrey Donnan, Stephen M. Davis, Bo Norrving, K. S. Lawrence Wong, Foad Abd‐Allah, Rohit Bhatia, Adnan Khan Tags: Review Source Type: research

Transient focal neurological episodes, cerebral amyloid angiopathy, and intracerebral hemorrhage risk: looking beyond TIAs
This article emphasizes new observations on transient focal neurological episodes in the context of cerebral amyloid angiopathy, a common but under‐recognized small vessel disease most often encountered as a cause of symptomatic lobar intracerebral hemorrhage. Transient focal neurological episodes in cerebral amyloid angiopathy are of clinical and pathophysiological interest because they can mimic transient ischemic attacks, but are probably more often related to bleeding (especially superficial cortical siderosis or focal convexity sub‐arachnoid hemorrhage) rather than ischemia. Importantly, such episodes may also her...
Source: International Journal of Stroke - January 21, 2013 Category: Neurology Authors: Andreas Charidimou, Jean‐Claude Baron, David J. Werring Tags: Leading opinion Source Type: research

Acute middle cerebral artery occlusion: reappraisal of the role of endovascular revascularization
Intravenous tissue plasminogen activator was the first successful stroke therapy in acute ischaemic stroke, after innumerable failed attempts at neuroprotection and neurorestoration. However, intravenous tissue type plasminogen activator has been shown to be effective in recanalizing middle cerebral artery occlusions in only about one‐third of cases. The natural history of untreated acute middle cerebral artery occlusion is poor, leading to long‐term disability in >70% and mortality in 20%. Recanalization alone is not the name of the game. Only timely, very rapid recanalization, achieved within minutes or at most a ...
Source: International Journal of Stroke - January 21, 2013 Category: Neurology Authors: José E. Cohen Tags: Leading opinion Source Type: research

Intra‐arterial thrombolysis vs. standard treatment or intravenous thrombolysis in adults with acute ischemic stroke: a systematic review and meta‐analysis
Conclusions This analysis finds a modest benefit of intra‐arterial thrombolysis over standard treatment, although it does not find a clear benefit of intra‐arterial thrombolysis over intravenous thrombolysis in acute ischemic stroke patients. However, few trials, small sample sizes, and indirectness limit the strength of evidence.
Source: International Journal of Stroke - January 7, 2013 Category: Neurology Authors: Julian Nam, He Jing, Daria O'Reilly Tags: Systematic Review Source Type: research

An epidemiological survey of stroke among rural Chinese adults results from the Liaoning province
ConclusionsThe annual incidence of stroke and resulting mortality has increased at an accelerated rate. Furthermore, the incidence of stroke in rural China was higher than that found in urban China and Western countries. Hypertension and lipid disorder were important modifiable risk factors. The primary sub‐type of stroke observed in rural China was ischemic stroke. These findings underscored the need for more aggressive efforts to control the risk factors of stroke and other cardiovascular diseases in rural areas.
Source: International Journal of Stroke - January 7, 2013 Category: Neurology Authors: Zhaoqing Sun, Liqiang Zheng, Robert Detrano, Xingang Zhang, Jue Li, Dayi Hu, Yingxian Sun Tags: Research Source Type: research