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A systematic review and meta ‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
ConclusionsThere is clear evidence for improvement in functional independence with endovascular thrombectomy compared with standard medical care, suggesting that endovascular thrombectomy should be considered the standard effective treatment alongside thombolysis in eligible patients.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Joyce S. Balami, Brad A. Sutherland, Laurel D. Edmunds, Iris Q. Grunwald, Ain A. Neuhaus, Gina Hadley, Hasneen Karbalai, Kneale A. Metcalf, Gabriele C. DeLuca, Alastair M. Buchan Tags: Review Source Type: research

Novel TIA biomarkers identified by mass spectrometry ‐based proteomics
ConclusionsUtilizing mass spectrometry‐based proteomics, platelet basic protein has been identified as a candidate serum biomarker for transient ischemic attack. This unbiased proteomic approach may be a promising method to identify novel biomarkers to more precisely diagnose transient ischemic attacks.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Paul M. George, Michael Mlynash, Christopher M. Adams, Calvin J. Kuo, Gregory W. Albers, Jean ‐Marc Olivot Tags: Research Source Type: research

Life ‐threatening coronary disease is prevalent in patients with stenosing carotid artery disease
ConclusionsEndarterectomized carotid patients have a high risk of acute myocardial infarction and death, and need an intensified cardiovascular disease‐risk‐lowering treatment. Although asymptomatic, the evaluation of prognostically significant myocardial ischemia should be considered in these high‐risk patients. Eventually, a clinical trial is needed to address whether carotid patients would benefit from early intervention.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Krista Nuotio, Lauri Soinne, Helena H änninen, Jani Saksi, Jarno Tuimala, Antti Jula, Petri T. Kovanen, Markku Kaste, Petra Ijäs, Perttu J. Lindsberg Tags: Research Source Type: research

Prognostic value of 24‐h ABPM in acute ischemic stroke for short‐, medium‐, and long‐term outcome: a systematic review and meta‐analysis
ConclusionsHigher systolic and diastolic blood pressure levels derived with ambulatory blood pressure monitoring were associated with poor outcome. The same was not found for higher casual blood pressure measurements on admission, and it is possible that ambulatory blood pressure monitoring conveys better prognostic information.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Nikolaos Kakaletsis, George Ntaios, Haralampos Milionis, Anna‐Bettina Haidich, Konstantinos Makaritsis, Christos Savopoulos, Eivind Berge, Apostolos I. Hatzitolios Tags: Review Source Type: research

Individual patient data meta‐analysis of antiplatelet regimens after noncardioembolic stroke or TIA: rationale and design
ConclusionsThis paper outlines inclusion criteria, outcome measures, baseline characteristics, and planned statistical analysis.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Jacoba P. Greving, Hans‐Christoph Diener, László Csiba, Werner Hacke, L. Jaap Kappelle, Peter J. Koudstaal, Didier Leys, Jean‐Louis Mas, Ralph L. Sacco, Juhani Sivenius, Ale Algra, Tags: Protocol Source Type: research

Statistical analysis plan for evaluating low‐ vs. standard‐dose alteplase in the ENhanced Control of Hypertension and Thrombolysis strokE stuDy (ENCHANTED)
ConclusionsWe have developed a predetermined statistical analysis plan for the ENhanced Control of Hypertension And Thrombolysis strokE stuDy alteplase dose arm which is to be followed to avoid analysis bias arising from prior knowledge of the study findings.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Craig S. Anderson, Mark Woodward, Hisatomi Arima, Xiaoying Chen, Richard I. Lindley, Xia Wang, John Chalmers, Tags: Protocol Source Type: research

Internet ‐based information‐seeking behavior for transient ischemic attack
International Journal of Stroke,Volume 10, Issue 8, Page 1212-1216, December 2015.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Source Type: research

Internet‐based information‐seeking behavior for transient ischemic attack
ConclusionsOur study shows that changes in online search behavior can be associated with media coverage of key events (in our case transient ischemic attack) in public figures. These findings suggest that multimedia health promotion campaigns might be more effective, if increased promptly after similar media coverage.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Vida Abedi, Marieme Mbaye, Georgios Tsivgoulis, Shailesh Male, Nitin Goyal, Andrei V. Alexandrov, Ramin Zand Tags: Research Source Type: research

Internet ‐based information‐seeking behavior for transient ischemic attack
International Journal of Stroke,Volume 10, Issue 8, Page 1212-1216, December 2015.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Vida Abedi , Marieme Mbaye , Georgios Tsivgoulis , Shailesh Male , Nitin Goyal , Andrei V. Alexandrov , Ramin Zand Source Type: research

Statistical analysis plan for evaluating low ‐ vs. standard‐dose alteplase in the ENhanced Control of Hypertension and Thrombolysis strokE stuDy (ENCHANTED)
ConclusionsWe have developed a predetermined statistical analysis plan for the ENhanced Control of Hypertension And Thrombolysis strokE stuDy alteplase dose arm which is to be followed to avoid analysis bias arising from prior knowledge of the study findings.
Source: International Journal of Stroke - August 17, 2015 Category: Neurology Authors: Craig S. Anderson, Mark Woodward, Hisatomi Arima, Xiaoying Chen, Richard I. Lindley, Xia Wang, John Chalmers, Tags: Protocol Source Type: research

The Clinical Relevance of Microbleeds in Stroke study (CROMIS‐2): rationale, design, and methods
Background and rationaleThe increasing use of oral anticoagulants, mostly to prevent ischemic stroke due to atrial fibrillation in an ageing population, has been associated with a fivefold increased incidence of oral anticoagulant‐associated intracerebral hemorrhage: a rare, serious, and unpredictable complication. We hypothesize that cerebral microbleeds and other markers of cerebral small vessel disease on magnetic resonance imaging, and genetic polymorphisms (e.g. influencing cerebral small vessel integrity or anticoagulation stability), are associated with an increased risk of oral anticoagulant‐associated intracer...
Source: International Journal of Stroke - August 2, 2015 Category: Neurology Authors: Andreas Charidimou, Duncan Wilson, Clare Shakeshaft, Gareth Ambler, Mark White, Hannah Cohen, Tarek Yousry, Rustam Al‐Shahi Salman, Gregory Lip, Henry Houlden, Hans R. Jäger, Martin M. Brown, David J. Werring Tags: Protocol Source Type: research

Endovascular treatment for acute ischemic stroke: Experience in South Australia
Source: International Journal of Stroke - July 23, 2015 Category: Neurology Authors: Laura Ivete Rudaks, Idin Ahangar, Lizzie Dodd, Austin Graham Milton, Monica Anne Hamilton‐Bruce, Jim Jannes, Simon Andrea Koblar Tags: Letter to the editor Source Type: research

Ischemic stroke on optimal anticoagulation with novel‐oral anticoagulants compared with warfarin
Source: International Journal of Stroke - July 23, 2015 Category: Neurology Authors: Bum Joon Kim, Hyun Goo Kang, Deok Hee Lee, Dong‐Wha Kang, Jong S. Kim, Sun U. Kwon Tags: Letter to the editor Source Type: research

Prevalence of stroke symptoms among stroke‐free residents: first national data from Lebanon
ConclusionsThis is the first study conducted in the Middle East, assessing self‐reported stroke symptoms among stroke‐free residents. Our study showed that almost one in eight residents without a history of stroke or transient ischemic attack has had stroke symptoms. Major vascular risk factors are associated with these symptoms, thus allowing for prevention strategies.
Source: International Journal of Stroke - July 14, 2015 Category: Neurology Authors: Rita Farah, Rouba Karen Zeidan, Mirna N. Chahine, Roland Asmar, Ramez Chahine, Pascale Salameh, Hassan Hosseini Tags: Research Source Type: research

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