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Source: BMJ Open

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Total 555 results found since Jan 2013.

Kidney transplantation waiting times and risk of cardiovascular events and mortality: a retrospective observational cohort study in Taiwan
Conclusions Our results demonstrate that early KT is associated with superior long-term cardiovascular outcomes compared with late KT in selected patients with ESRD receiving uncomplicated KT, suggesting that an early KT could be a better treatment option for patients with ESRD who are eligible for transplantation.
Source: BMJ Open - May 24, 2022 Category: General Medicine Authors: Chen, H.-H., Chern, Y.-B., Hsu, C.-Y., Tang, P.-L., Lai, C.-C. Tags: Open access, Epidemiology Source Type: research

Stroke volume variation for predicting responsiveness to fluid therapy in patients undergoing cardiac and thoracic surgery: a systematic review and meta-analysis
Conclusion SVV had good predictive performance in cardiac surgery or ICU after cardiac surgery and had moderate predictive performance in thoracic surgery. Nevertheless, technical and clinical variables may affect the predictive value potentially.
Source: BMJ Open - May 18, 2022 Category: General Medicine Authors: Huan, S., Dai, J., Song, S., Zhu, G., Ji, Y., Yin, G. Tags: Open access, Anaesthesia Source Type: research

Indoor solid fuel use for cooking and the risk of incidental non-fatal cardiovascular disease among middle-aged and elderly Chinese adults: a prospective cohort study
Conclusions This cohort study provides evidence for the effects of solid fuel use on incidental non-fatal CVD in middle-aged and elderly Chinese adults. Advocating for the use of clean energy and ventilation stoves is important to cardiovascular health.
Source: BMJ Open - May 17, 2022 Category: General Medicine Authors: Ji, H., Chen, Q., Wu, R., Xu, J., Chen, X., Du, L., Chen, Y., Pan, Y., Duan, Y., Sun, M., Zhou, L. Tags: Open access, Public health Source Type: research

Calligraphy-based rehabilitation exercise for improving the upper limb function of stroke patients: protocol for an evaluator-blinded randomised controlled trial
This study aims to design a randomised controlled trial to assess the effect of a customised CCH-based exercise for poststroke rehabilitation of upper limb dysfunction. Methods and analysis A single-blinded randomised controlled trial will be conducted on 60 stroke patients. The patients will be randomly allocated into three groups: (1) conventional occupational therapy (COT) group, (2) COT+CCH group, (3) COT+Graded Repetitive Arm Supplementary Program (GRASP) group. For the COT group, patients will receive COT treatment of 1 hour/day. For the COT+CCH group, patients will receive 30 mins COT treatment and 30 mins CCH trai...
Source: BMJ Open - May 13, 2022 Category: General Medicine Authors: Wu, X., Zhang, Q., Qiao, J., Chen, N., Wu, X. Tags: Open access, Rehabilitation medicine Source Type: research

Cohort profile: Outcomes & Multi-morbidity In Type 2 diabetes (OMIT) - a national registry-based observational cohort with focus on care and treatment of key high-risk groups in Norway
Purpose The ‘Outcomes & Multi-morbidity in Type 2 Diabetes’ (OMIT) is an observational registry-based cohort of Norwegian patients with type 2 diabetes (T2D) established to study high-risk groups often omitted from randomised clinical trials. Participants The OMIT cohort includes 57 572 patients with T2D identified via linkage of Norwegian Diabetes Register for Adults and the Rogaland-Oslo-Salten-Akershus-Hordaland study, both offering data on clinical patient characteristics and drug prescriptions. Subsequently these data are further linked to the Norwegian Prescription Database for dispensed medications,...
Source: BMJ Open - May 11, 2022 Category: General Medicine Authors: Forster, R. B., Strandberg, R. B., Bo Tibballs, K. L., Nokleby, K., Berg, T. J., Iversen, T., Hagen, T. P., Richardsen, K. R., Cooper, J., Sandberg, S., Lovaas, K. F., Nilsen, R. M., Iversen, M. M., Jenum, A. K., Buhl, E. S. S. Tags: Open access, Diabetes and Endocrinology Source Type: research

Atrial cardiomyopathy in patients with ischaemic stroke: a cross-sectional and prospective cohort study--the COAST study
This study uses cardiac magnetic resonance (CMR) to evaluate atrial cardiomyopathy among patients with stroke of undetermined aetiology compared with those with an attributable mechanism and controls without established cardiovascular disease. Methods and analysis This cross-sectional and prospective cohort study included 100 patients with recent ischaemic stroke and 50 controls with no established cardiovascular disease. The study will assess LA structural and functional abnormalities with CMR. Inclusion began in March 2019, and follow-up is planned to be complete in January 2023. There are two scheduled follow-ups: (1) ...
Source: BMJ Open - May 11, 2022 Category: General Medicine Authors: Larsen, B. S., Aplin, M., Host, N., Dominguez, H., Christensen, H., Christensen, L. M., Havsteen, I., Prescott, E., Jensen, G. B., Vejlstrup, N., Bertelsen, L., Sajadieh, A. Tags: Open access, Cardiovascular medicine Source Type: research

Do P2Y12 receptor inhibitors prescribed poststroke modify the risk of cognitive disorder or dementia? Protocol for a target trial using multiple national Swedish registries
This study has been approved by the Ethics Committee of the University of Gothenburg and Confidentiality Clearance at Statistics Sweden with Dnr 937-18, and an approved addendum with Dnr 2019-0157. The analysis and interpretation of the results will be heavily reliant on the structure, quality and potential for bias of the databases used. When we implement the protocol, we will consider and document any biases specific to the dataset and conduct appropriate sensitivity analyses. Findings will be disseminated to local stakeholders via conferences, and published in appropriate scientific journals.
Source: BMJ Open - May 9, 2022 Category: General Medicine Authors: Hinwood, M., Nyberg, J., Leigh, L., Gustavsson, S., Attia, J., Oldmeadow, C., Ilicic, M., Linden, T., Aberg, N. D., Levi, C., Spratt, N., Carey, L. M., Pollack, M., Johnson, S. J., Kuhn, G. H., Walker, F. R., Nilsson, M. Tags: Open access, Neurology Source Type: research

Decreasing rates of cost-related medication non-adherence by age advancement among American generational cohorts 2004-2014: a longitudinal study
Conclusion The paradox of decreasing CRN rates, independent of disease burden, income and insurance status, suggests populations’ CRN behaviours change as Americans age, bearing implications to social policy.
Source: BMJ Open - May 6, 2022 Category: General Medicine Authors: Zhang, J., Bhaumik, D., Meltzer, D. Tags: Open access, Health economics Source Type: research

Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial
Background There are a paucity of randomised data on the optimal timing of invasive coronary angiography (ICA) in higher-risk patients with non-ST elevation myocardial infarction (N-STEMI). International guideline recommendations for early ICA are primarily based on retrospective subgroup analyses of neutral trials. Aims The RAPID N-STEMI trial aims to determine whether very early percutaneous revascularisation improves clinical outcomes as compared with a standard of care strategy in higher-risk N-STEMI patients. Methods and analysis RAPID N-STEMI is a prospective, multicentre, open-label, randomised-controlled, pragmat...
Source: BMJ Open - May 3, 2022 Category: General Medicine Authors: Kite, T. A., Banning, A. S., Ladwiniec, A., Gale, C. P., Greenwood, J. P., Dalby, M., Hobson, R., Barber, S., Parker, E., Berry, C., Flather, M. D., Curzen, N., Banning, A. P., McCann, G. P., Gershlick, A. H. Tags: Open access, Cardiovascular medicine, COVID-19 Source Type: research

Predictors for the prognosis and recurrence of ischaemic stroke among young Chinese patients: a cohort study
Conclusions Our research shows that when developing prevention strategies for young people, measures that focus on mitigating risk factors should be considered. In addition, vascular screening of young populations is also of vital importance for stroke prevention and poor prognosis prediction.
Source: BMJ Open - May 2, 2022 Category: General Medicine Authors: Wang, L., Ge, J., Chen, Y., Liu, Y., Li, C., Dong, Y., Liu, L., Xing, Y. Tags: Open access, Neurology Source Type: research

242 Large vessel occlusion stroke in an emergency call: A descriptive analysis of emergency calls for thrombectomy candidates
ConclusionIn the emergency calls for patients with paramedic-suspected large vessel occlusion, typical stroke symptoms were described. The severity of the stroke stood out by the patients’ inability to speak any words or remain standing. It is possible to further develop stroke dispatch protocols to recognise thrombectomy candidates already during an emergency call.Conflict of interestNone.FundingNone.
Source: BMJ Open - May 1, 2022 Category: General Medicine Authors: Vuorinen, P., Kiili, J., Alanko, E., Huhtala, H., Ollikainen, J., Setälä, P., Hoppu, S. Tags: Open access Dispatch and triage Source Type: research

249 The association of comorbidities and survival after out-of-hospital cardiac arrest in Denmark
ConclusionComorbidities significantly influence survival of OHCA patients. Cardiovascular comorbidities constitute the major part of the disease burden. The influence of comorbidity should be included in future treatment guidelines of OHCA patients.Conflict of interestNone.FundingNone.
Source: BMJ Open - May 1, 2022 Category: General Medicine Authors: Sodergren, S., Moller, S., Pedersen, C., Folke, F., Ersboll, A. Tags: Open access Cardiac arrest Source Type: research

Chronic high-altitude exposure and the epidemiology of ischaemic stroke: a systematic review
Conclusions This review suggests that the most robust studies are more likely to find that prolonged living at higher altitudes reduces the risk of developing stroke or dying from it. Increased irrigation due to angiogenesis and increased vascular perfusion might be the reason behind improved survival profiles among those living within this altitude range. In contrast, residing above 3500 m seems to be associated with an apparent increased risk of developing stroke, probably linked to the presence of polycythaemia and other associated factors such as increased blood viscosity.
Source: BMJ Open - April 29, 2022 Category: General Medicine Authors: Ortiz-Prado, E., Cordovez, S. P., Vasconez, E., Viscor, G., Roderick, P. Tags: Open access, Neurology Source Type: research

Longitudinal evaluation of treatment patterns, risk factors and outcomes in patients with cardiovascular disease treated with lipid-lowering therapy in the UK
Conclusions Despite an increase in high-intensity therapy use and a decline in revascularisation, more than half of patients did not receive high-intensity lipid-lowering therapy by 2017 and incidence rates of MI and IS remained virtually unchanged.
Source: BMJ Open - April 29, 2022 Category: General Medicine Authors: Danese, M., Sidelnikov, E., Villa, G., Catterick, D., Iqbal, M., Gleeson, M., Lubeck, D., Patel, J. Tags: Open access, Cardiovascular medicine Source Type: research

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (Mobile Stroke Unit--TASTE-A): protocol for a prospective randomised, open-label, blinded endpoint, phase II superiority trial of tenecteplase versus alteplase for ischaemic stroke patients presenting within 4.5 hours of symptom onset to the mobile stroke unit
Introduction Mobile stroke units (MSUs) equipped with a CT scanner are increasingly being used to assess and treat stroke patients’ prehospital with thrombolysis and transfer them to the most appropriate hospital for ongoing stroke care and thrombectomy when indicated. The effect of MSUs in both reducing the time to reperfusion treatment and improving patient outcomes is now established. There is now an opportunity to improve the efficacy of treatment provided by the MSU. Tenecteplase is a potent plasminogen activator, which may have benefits over the standard of care stroke lytic alteplase. Specifically, in the MSU ...
Source: BMJ Open - April 29, 2022 Category: General Medicine Authors: Bivard, A., Zhao, H., Coote, S., Campbell, B., Churilov, L., Yassi, N., Yan, B., Valente, M., Sharobeam, A., Balabanski, A., Dos Santos, A., Ng, F., Langenberg, F., Stephenson, M., Smith, K., Bernard, S., Thijs, V., Cloud, G., Choi, P., Ma, H., Wijeratne, Tags: Open access, Neurology Source Type: research