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Total 555 results found since Jan 2013.

Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk
Introduction Current efforts to reduce dementia focus on prevention and risk reduction by targeting modifiable risk factors. As dementia and cardiometabolic non-communicable diseases (NCDs) share risk factors, a single risk-estimating tool for dementia and multiple NCDs could be cost-effective and facilitate concurrent assessments as compared with a conventional single approach. The aim of this study is to develop and validate a new risk tool that estimates an individual’s risk of developing dementia and other NCDs including diabetes mellitus, stroke and myocardial infarction. Once validated, it could be used by the ...
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Kootar, S., Huque, M. H., Kiely, K. M., Anderson, C. S., Jorm, L., Kivipelto, M., Lautenschlager, N. T., Matthews, F., Shaw, J. E., Whitmer, R. A., Peters, R., Anstey, K. J. Tags: Open access, Public health Source Type: research

Prevalence and risk factors of stroke in high-altitude areas: a systematic review and meta-analysis
Conclusions The findings of this study provide insights into the pooled prevalence of stroke in high-altitude areas, highlighting variations based on geographic regions and sampling type. Moreover, age, gender, hypertension and obesity were found to be associated with the occurrence of stroke. PROSPERO registration number CRD42022381541.
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Zheng, B., Luo, Y., Li, Y., Gu, G., Jiang, J., Chen, C., Chen, Z., Wang, J. Tags: Open access, Neurology Source Type: research

Adult mortality trends in Matlab, Bangladesh: an analysis of cause-specific risks
Conclusion Deaths from stroke, heart disease and cancers were either on the rise or remained unchanged, but other causes declined continuously from 2003 to 2017. Immediate strengthening of the preventive and curative healthcare systems for NCDs management is a burning need.
Source: BMJ Open - September 19, 2023 Category: General Medicine Authors: Ahmed, A., Nahian, M. A., Rahman, M. M., Alam, N., Nahar, Q., Streatfield, P. K., Haider, M. M., Rahman, M. Tags: Open access, Public health Source Type: research

Soluble C-type lectin-like receptor 2 in stroke (CLECSTRO) study: protocol of a multicentre, prospective cohort of a novel platelet activation marker in acute ischaemic stroke and transient ischaemic attack
This study was approved by the Ethical Committee of the University of Yamanashi as the central ethical committee in agreement with the ethical committees of all collaborative stroke centres. Informed consent will be obtained by an opt-out form from the patients at each stroke centre according to the Ethical Guidelines for Medical and Biological Research Involving Human Subjects by the Japanese Ministry of Health, Labour and Welfare. Trial registration numbers NCT05579405, UMIN000048954
Source: BMJ Open - September 18, 2023 Category: General Medicine Authors: Uchiyama, S., Suzuki-Inoue, K., Wada, H., Okada, Y., Hirano, T., Nagao, T., Kinouchi, H., Itabashi, R., Hoshino, H., Oki, K., Honma, Y., Ito, N., Sugimori, H., Kawamura, M. Tags: Open access, Diagnostics Source Type: research

Effect of exoskeleton robot-assisted training on gait function in chronic stroke survivors: a systematic review of randomised controlled trials
Conclusion ERAT could be an efficient intervention to improve gait function for individuals who had a chronic stroke. However, more rigorously designed trials are required to draw more solid evidence. PROSPERO registration number CRD42023410796.
Source: BMJ Open - September 14, 2023 Category: General Medicine Authors: Yang, J., Gong, Y., Yu, L., Peng, L., Cui, Y., Huang, H. Tags: Open access, Rehabilitation medicine Source Type: research

Incidence, characteristics and outcome of post-stroke recrudescence in the Chinese population: a single-centre observational study
Conclusions PSR is not uncommon in patients presenting with stroke symptoms and can be distinguished from TIA and SMs based on a combination of clinical features and trigger in the Chinese population. The neurological deficits of patients with PSR often resolve within several days following the resolution of the trigger.
Source: BMJ Open - September 13, 2023 Category: General Medicine Authors: Pu, M.-J., Yu, J.-L., Hu, X., Deng, L., Chen, C., Lv, X.-N., Li, Z.-Q., Wang, Z.-J., Xie, P., Li, Q. Tags: Open access, Neurology Source Type: research

Retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults
Conclusion PM2.5 and systemic corticosteroid use were independently associated with increases in CTE hospitalisations. We also found evidence of significant additive interactions between the two exposures for HF and MI/ACSs suggesting synergy between these two exposures.
Source: BMJ Open - September 13, 2023 Category: General Medicine Authors: Josey, K., Nethery, R., Visaria, A., Bates, B., Gandhi, P., Parthasarathi, A., Rua, M., Robinson, D., Setoguchi, S. Tags: Open access, Epidemiology Source Type: research

Incidence of atrial fibrillation in cryptogenic stroke with patent foramen ovale closure: protocol for the prospective, observational PFO-AF study
Introduction After closure of patent foramen ovale (PFO) due to stroke, atrial fibrillation (AF) occurs in up to one in five patients. However, data are sparse regarding the possible pre-existence of AF in these patients prior to PFO closure, and about recurrence of AF in the long term after the procedure. No prospective study to date has investigated these topics in patients with implanted cardiac monitor (ICM). The PFO-AF study (registered with ClinicalTrials.gov under the number NCT04926142) will investigate the incidence of AF occurring within 2 months after percutaneous closure of PFO in patients with prior stroke. AF...
Source: BMJ Open - September 12, 2023 Category: General Medicine Authors: Badoz, M., Derimay, F., Serzian, G., Besutti, M., Rioufol, G., Frey, P., Guenancia, C., Ecarnot, F., Meneveau, N., Chopard, R. Tags: Open access, Cardiovascular medicine Source Type: research

Intervention to reduce sedentary behaviour and improve outcomes after stroke (Get Set Go): a study protocol for the process evaluation of a pilot cluster randomised controlled trial (RECREATE)
We report the protocol for the process evaluation which will address the following objectives: (1) describe and clarify causal assumptions about the intervention, and its mechanisms of impact; (2) assess implementation fidelity; (3) explore views, perceptions and acceptability of the intervention to staff, stroke survivors and their carers; (4) establish the contextual factors that influence implementation, intervention mechanisms and outcomes. Methods and analysis This pilot trial will be conducted in 15 UK-based National Health Service stroke services. This process evaluation study, underpinned by the Medical Research C...
Source: BMJ Open - September 12, 2023 Category: General Medicine Authors: Johansson, J. F., Shannon, R., Mossabir, R., Airlie, J., Ozer, S., Moreau, L. A., Farrin, A., Mead, G., English, C., Fitzsimons, C. F., Clarke, D. J., Forster, A., on behalf of the RECREATE Programme Management Group, RECREATE Programme Management Group, Tags: Open access, Rehabilitation medicine Source Type: research

Remote interventions for informal caregivers of patients with stroke: a systematic review and meta-analysis
Conclusions Current evidence suggests that remote interventions for informal caregivers of patients who had a stroke have no significant superiority over traditional interventions. However, the quality of the included studies was low and more high-quality evidence is required to determine the possible impacts of remote interventions. PROSPERO registration number CRD42022313544.
Source: BMJ Open - September 11, 2023 Category: General Medicine Authors: Yu, T., Ren, J.-w., Wang, C., Liu, S.-s., Cun, W., Jiang, Y. Tags: Open access, Nursing Source Type: research

Association of baseline fasting plasma glucose with 1-year mortality in non-diabetic patients with acute cerebral infarction: a multicentre observational cohort study
Conclusion In non-diabetic patients with ACI, elevated baseline FPG is an independent risk factor for 1-year all-cause mortality, and the two are positively and non-linearly associated. These results suggest that high FPG should be seen as a concern in non-diabetic patients with ACI.
Source: BMJ Open - September 6, 2023 Category: General Medicine Authors: Zhang, D., Liu, Z., Liu, P., Zhang, H., Guo, W., Lu, Q., Huang, C., Wang, J., Chang, Q., Zhang, M., Huo, Y., Wang, Y., Lin, X., Wang, F., Wu, S. Tags: Open access, Neurology Source Type: research

Association between diseases of despair and atherosclerotic cardiovascular disease among insured adults in the USA: a retrospective cohort study from 2017 to 2021
Conclusions Among this cohort of insured adults, documented DoD was associated with increased ASCVD risk. Further research to understand and address cardiovascular disease prevention in those with DoD could reduce costs, morbidity and mortality. Further examination of overlapping structural factors that may be contributing to concurrent rises in ASCVD and DoD in the USA is needed.
Source: BMJ Open - September 6, 2023 Category: General Medicine Authors: Nudy, M., Galper, K., George, D. R., Williams, B. A., Kraschnewski, J. L., Sinoway, L., Brignone, E. Tags: Open access, Cardiovascular medicine Source Type: research

Effectiveness of a smartphone-enabled dyadic self-care programme (SDSCP) for stroke survivors and caregivers: study protocol for a randomised controlled trial
This study has been approved by the Ethics Committee of Zhengzhou University (ZZUIRB 2021–115) in January 2021. The results achieved in this study will facilitate the clinical practice to improve self-care of stroke survivors and promote dyadic health outcomes for stroke patients and caregivers. Trial registration number The study was registered with the Chinese Clinical Trial Registry and the registration number is ChiCTR2100053591.
Source: BMJ Open - September 4, 2023 Category: General Medicine Authors: Wang, W., Wang, X., Vellone, E., Zhang, Z. Tags: Open access, Nursing Source Type: research

Temporal trends of hypertrophic cardiomyopathy in Denmark: a nationwide retrospective cohort study
Conclusion There was a consistent rise in HCM cases with decreasing morbidity burden. Females were older at diagnosis and more likely to have their type of HCM classified as obstructive. The rate of outpatient follow-up is increasing.
Source: BMJ Open - September 4, 2023 Category: General Medicine Authors: Zörner, C. R., Pallisgaard, J., Schjerning, A.-M., Jensen, M. K., Tonnesen, J., Da Riis-Vestergaard, L., Middelfart, C., Rasmussen, P. V., Gislason, G., Hansen, M. L. Tags: Open access, Cardiovascular medicine Source Type: research

SocialBit: protocol for a prospective observational study to validate a wearable social sensor for stroke survivors with diverse neurological abilities
This study has received ethical approval from the Institutional Review Board of Mass General Brigham (Protocol #2020P003739). The results of this study will be published in a peer-reviewed journal.
Source: BMJ Open - August 28, 2023 Category: General Medicine Authors: White, K., Tate, S., Zafonte, R., Narayanan, S., Mehl, M. R., Shin, M., Dhand, A. Tags: Open access, Research methods Source Type: research