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Source: BMJ Open

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Total 555 results found since Jan 2013.

Haemodynamic effects of a 10-min treatment with a high inspired oxygen concentration in the emergency department: a prospective observational study
Conclusion Exposure of patients to a high FiO2 for 5–10 min results in a significant drop in CO in one out of four patients. Therefore, even in the ED and in prehospital care, where oxygen is administered for a limited amount of time, FiO2 should be titrated based on deficit whenever this is feasible and high flow oxygen should not be given as a routine treatment.
Source: BMJ Open - September 1, 2022 Category: General Medicine Authors: Stolmeijer, R., van Ieperen, E., Lameijer, H., van Beest, P., ter Maaten, J. C., ter Avest, E. Tags: Open access, Emergency medicine Source Type: research

Treatment patterns for oral anticoagulants in older patients with atrial fibrillation: a retrospective, cross-sectional, nationwide study from Denmark
Conclusion In this large nationwide study, we found that in older patients with AF, the overall rates of OAC prescription were generally high (~80%) and increasing during the last decade. Factors associated with not receiving guideline recommended OAC treatment were generally related to bleeding risk factors or frailty.
Source: BMJ Open - September 1, 2022 Category: General Medicine Authors: Rasmussen, P. V., Sakthivel, T., Dalgaard, F., Gislason, G. H., Pallisgaard, J. L., Hansen, M. L. Tags: Open access, Cardiovascular medicine Source Type: research

Cost-effectiveness of follow-up invasive coronary angiography after percutaneous coronary stenting: a real-world observational cohort study in Japan
Conclusions FUICA increased the costs but did not improve clinical benefits. Thus, FUICA is not economically more attractive than CF alone. Trial registration number UMIN000039768.
Source: BMJ Open - August 30, 2022 Category: General Medicine Authors: Shiina, T., Goto-Hirano, K., Takura, T., Daida, H. Tags: Open access, Health economics Source Type: research

Prevalence and associated factors of physical inactivity among middle-aged and older adults in India: results of a national cross-sectional community survey
Conclusions Almost 4 in 10 middle-aged and older adults in India had inadequate physical activity. Overall and gender specific risk factors for physical inactivity were identified. Interventions may operate at multiple levels and consider gender-related physical inactivity patterns.
Source: BMJ Open - August 26, 2022 Category: General Medicine Authors: Pengpid, S., Peltzer, K. Tags: Open access, Global health Source Type: research

Temporal trend of first-ever ischaemic stroke incidence from 2010 to 2019 in South Korea: a nationwide retrospective cohort study
Conclusions Age-standardised incidence rate of ischaemic stroke has decreased from 2010 to 2019 for both man and women. The incidence rate was stable in the younger age groups and decreased in the older age groups, and the disparities between income groups have widened over the past decade. Stroke prevention strategies are needed for the younger age group and the low-income group. Further research is needed to study the risk factors contributing to the incidence of ischaemic stroke in different groups.
Source: BMJ Open - August 24, 2022 Category: General Medicine Authors: Lee, J., Kim, H., Moon, J., Shin, J., Jeong, H., Kim, Y. Tags: Open access, Epidemiology Source Type: research

COVID-19 postacute care major organ damage: a systematic review
Conclusions and implications of key findings Postacute COVID-19 major organ damage is common and likely higher than controls. However, there is substantial uncertainty. More consistent reporting of clinical outcomes and pre-COVID health status along with careful selection of control groups are needed to address evidence gaps. PROSPERO registration number CRD42020204788.
Source: BMJ Open - August 24, 2022 Category: General Medicine Authors: Greer, N., Bart, B., Billington, C. J., Diem, S. J., Ensrud, K. E., Kaka, A., Klein, M., Melzer, A. C., Reule, S., Shaukat, A., Sheets, K., Starks, J., Vardeny, O., McKenzie, L., Stroebel, B., Macdonald, R., Sowerby, K., Duan-Porter, W., Wilt, T. J. Tags: Open access, Infectious diseases, COVID-19 Source Type: research

Reporting dose in complex self-management support interventions for long-term conditions: is it defined by researchers and received by participants? A systematic review
Conclusions Interpreting results and implementing effective complex self-management interventions is difficult when researchers’ reporting of dose is not in line with guidelines. If trial findings indicate benefit from the intervention, clear reporting of dose ensures reliable implementation to standard care. If the results are non-significant, detailed reporting enables better interpretation of results, that is, differentiating between poor implementation and lack of effectiveness. This ensures quality of interventions and validity and generalisability of trial findings. Therefore, wider adoption of reporting the TI...
Source: BMJ Open - August 17, 2022 Category: General Medicine Authors: Rookes, T. A., Barat, A., Turner, R., Taylor, S. Tags: Open access, Evidence based practice Source Type: research

Outcome disparities in patients with atrial fibrillation based on insurance plan and educational attainment: a nationwide, multicenter and prospective cohort trial
Conclusion Educational attainment was independently associated with all-cause mortality and ischaemic stroke in patients with AF, but adverse clinical outcomes were not related to the types of health insurance in Thailand. Trial registration number Thai Clinical Trial Registration; Study ID: TCTR20160113002.
Source: BMJ Open - August 10, 2022 Category: General Medicine Authors: Apiyasawat, S., Thongsri, T., Jongpiputvanich, K., Krittayaphong, R., for the COOL-AF Investigators Tags: Open access, Cardiovascular medicine Source Type: research

rTMS for poststroke pusher syndrome: study protocol for a randomised, patient-blinded controlled clinical trial
Introduction Poststroke pusher syndrome (PS) prevalence is high. Patients with PS require longer rehabilitation with prolonged length of stay. Effective treatment of PS remains a challenge for rehabilitation professionals. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that is effective and recommended in the clinical guidelines of stroke rehabilitation. However, the role of rTMS for PS has not been examined. The study is to assess the efficacy of a specific rTMS programme for patients with PS in reducing pushing behaviour, enhancing motor recovery and improving mobility, as...
Source: BMJ Open - August 10, 2022 Category: General Medicine Authors: Meng, L., Tsang, R. C. C., Ge, Y., Guo, Q., Gao, Q. Tags: Open access, Rehabilitation medicine Source Type: research

Community-based interventions to prevent stroke in low-income and middle-income countries: a protocol for a systematic review and meta-analysis
Introduction Stroke is the second leading cause of death and morbidity across the globe. In low-income and middle-income countries (LMICs), it has become an overwhelming burden over the past few decades. This burden is escalating at a much greater pace compared with that of high-income countries. It is considered the most frequent cause of adult disability that affects the quality of life. ‘Prevention’ is one of the key components to combating stroke. In this regard, community-based interventions can play a vital role in improving population-level health and well-being. Considering the escalating trend of strok...
Source: BMJ Open - August 8, 2022 Category: General Medicine Authors: Nowrin, I., Bhattacharyya, D. S., Saif-Ur-Rahman, K. M. Tags: Open access, Epidemiology Source Type: research

Cost-free pharmacotherapy in smokers with TIA or stroke: QUIT-MED randomised controlled trial
Conclusions Our findings were inconclusive; we failed to meet our recruitment target and the effect size was smaller than anticipated. CF medication improved medication adherence. Trial registration number NCT00962988; ClinicalTrials.gov Identifier.
Source: BMJ Open - August 5, 2022 Category: General Medicine Authors: Reid, R., Papadakis, S., Gocan, S., Bourgoin, A., Laplante, M. A., Armstrong, A., Aitken, D., Sahlas, D., Stotts, G., Cotie, L., Mullen, K.-A., Pipe, A., Mir, H., Sharma, M. Tags: Open access, Smoking and tobacco Source Type: research

Prevalence and correlates of self-reported cardiovascular disease in Mongolia: findings from the 2019 Mongolia STEPS cross-sectional survey
Conclusions Almost one in seven people aged 15–69 years had IHDS in Mongolia. Several factors amenable to public health intervention for IHDS were identified, including experience of threats, hypertension, current tobacco use, passive smoking and sedentary behaviour.
Source: BMJ Open - August 5, 2022 Category: General Medicine Authors: Pengpid, S., Peltzer, K. Tags: Open access, Cardiovascular medicine Source Type: research

Study protocol of a non-randomised controlled trial evaluating the effectiveness of the F@ce 2.0 programme: a person-centred, ICT-supported and interdisciplinary rehabilitation intervention after stroke
Introduction Knowledge is missing on use of information and communication technology (ICT), for example, mobile phones/tablets in rehabilitation after stroke. F@ce 2.0 is a person-centred, interdisciplinary intervention supported by ICT. The components of F@ce 2.0 intend to increase performance in daily activities and participation in everyday life for patients with stroke and their significant others. Based on previous feasibility studies, a full-scale evaluation is planned in Sweden. The aim is to implement and evaluate F@ce 2.0, regarding performance of daily activities and participation in everyday life, in comparison ...
Source: BMJ Open - August 4, 2022 Category: General Medicine Authors: Eriksson, G., Tistad, M., Elf, M., Fors, U., von Koch, L., Ytterberg, C., Guidetti, S. Tags: Open access, Rehabilitation medicine Source Type: research

Life satisfaction and its influencing factors of middle-aged and elderly stroke patients in China: a national cross-sectional survey
Conclusions Our study indicates the importance of improving the overall health of patients who had a stroke and mediating factors, such as pain management, and work ability, spouse and children relationship in improving the life satisfaction of patients in the poststroke rehabilitation.
Source: BMJ Open - August 3, 2022 Category: General Medicine Authors: Liu, Y., Liu, J., Zhou, S., Xu, X., Cheng, Y., Yi, Y., Zou, G. Tags: Open access, Public health Source Type: research

Effectiveness and implementation of SHared decision-making supported by OUTcome information among patients with breast cancer, stroke and advanced kidney disease: SHOUT study protocol of multiple interrupted time series
Introduction Within the value-based healthcare framework, outcome data can be used to inform patients about (treatment) options, and empower them to make shared decisions with their health care professional. To facilitate shared decision-making (SDM) supported by outcome data, a multicomponent intervention has been designed, including patient decision aids on the organisation of post-treatment surveillance (breast cancer); discharge location (stroke) and treatment modality (advanced kidney disease), and training on SDM for health care professionals. The SHared decision-making supported by OUTcome information (SHOUT) study ...
Source: BMJ Open - August 1, 2022 Category: General Medicine Authors: Hackert, M. Q. N., Ankersmid, J. W., Engels, N., Prick, J. C. M., Teerenstra, S., Siesling, S., Drossaert, C. H. C., Strobbe, L. J. A., van Riet, Y. E. A., van den Dorpel, R. M. A., Bos, W. J. W., van der Nat, P. B., van den Berg-Vos, R. M., van Schaik, S Tags: Open access, Health services research Source Type: research