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Source: BMJ Open

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Total 555 results found since Jan 2013.

Effect of home-based interventions on basic activities of daily living for patients who had a stroke: a systematic review with meta-analysis
Conclusion Home-based rehabilitation with usual care, which varied from no therapy to inpatient or outpatient therapy, may have a short-term effect on the ability to do basic activities of daily living for patients who had a stroke compared with usual care alone. However, the evidence quality is low because of the limited number of studies and participants included in the meta-analysis and the possible publication bias. Future research is needed to investigate the effectiveness of home-based rehabilitation in groups with stratification by stroke severity and time since stroke onset, with elaboration of details of the home-...
Source: BMJ Open - July 28, 2022 Category: General Medicine Authors: Qin, P., Cai, C., Chen, X., Wei, X. Tags: Open access, Rehabilitation medicine Source Type: research

Impact of multimorbidity and complex multimorbidity on mortality among older Australians aged 45 years and over: a large population-based record linkage study
Conclusion MM and CMM were common in older Australian adults; and MM was a better predictor of all-cause mortality risk than CMM. Higher mortality risk in those aged 45–59 years indicates tailored, person-centred integrated care interventions and better access to holistic healthcare are needed for this age group.
Source: BMJ Open - July 26, 2022 Category: General Medicine Authors: Kabir, A., Tran, A., Ansari, S., Conway, D. P., Barr, M. Tags: Open access, Geriatric medicine Source Type: research

Impact of multimorbidity on long-term outcomes in older adults with non-ST elevation acute coronary syndrome in the North East of England: a multi-centre cohort study of patients undergoing invasive care
Conclusions In older adults with NSTE-ACS referred for coronary angiography, the presence of multimorbidity is associated with an increased risk of long-term adverse cardiovascular events, driven by a higher risk of all-cause mortality. Trial registration number NCT01933581; ClinicalTrials.gov.
Source: BMJ Open - July 26, 2022 Category: General Medicine Authors: Beska, B., Mills, G. B., Ratcovich, H., Wilkinson, C., Damluji, A. A., Kunadian, V. Tags: Open access, Cardiovascular medicine Source Type: research

Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years
Conclusions This is an under-reported research area and the findings suggest the codes’ usage diversity for most conditions remained overall stable throughout the study period. Generated mental health code lists can last for a long time unlike cardiometabolic conditions and cancer. Adopting more consistent and less diverse coding would help improve data quality in primary care. Future research is needed following the transfer to the Systematised Nomenclature of Medicine Clinical Terms (SNOMED CT) coding.
Source: BMJ Open - July 25, 2022 Category: General Medicine Authors: Zghebi, S. S., Reeves, D., Grigoroglou, C., McMillan, B., Ashcroft, D. M., Parisi, R., Kontopantelis, E. Tags: Open access, General practice / Family practice Source Type: research

Association of immunoglobulin G N-glycosylation with carotid atherosclerotic plaque phenotypes and actual clinical cardiovascular events: a study protocol for a longitudinal prospective cohort study
Introduction Immune-inflammatory response plays a key role in the pathogenesis of atherosclerosis. IgG N-glycosylation is reported to be associated with the 10-year atherosclerotic cardiovascular disease risk score and subclinical atherosclerosis. However, the relationship of IgG glycosylation with actual clinical cardiovascular disease (CVD) events and plaque phenotypes has rarely been investigated. Therefore, this study aims to understand whether IgG glycosylation traits are correlated with actual clinical CVD events and plaque phenotypes. Methods and analysis Designed to verify the efficacy of IgG glycosylation as a ri...
Source: BMJ Open - July 22, 2022 Category: General Medicine Authors: Tian, C., Mahara, G., Zhang, H., Tan, X. Tags: Open access, Cardiovascular medicine Source Type: research

Real-world, feasibility study to investigate the use of a multidisciplinary app (Pulsara) to improve prehospital communication and timelines for acute stroke/STEMI care
Conclusions In this Australian-first study, uptake of the digital communication app was strong, patient-centred care timelines improved, although door-to-treatment times remained similar.
Source: BMJ Open - July 18, 2022 Category: General Medicine Authors: Bladin, C. F., Bagot, K. L., Vu, M., Kim, J., Bernard, S., Smith, K., Hocking, G., Coupland, T., Pearce, D., Badcock, D., Budge, M., Nadurata, V., Pearce, W., Hall, H., Kelly, B., Spencer, A., Chapman, P., Oqueli, E., Sahathevan, R., Kraemer, T., Hair, C. Tags: Open access, Communication Source Type: research

Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial
The objective of the study was to explore the use of long-term home-based ECG monitoring for AF detection and stroke prevention in patients with a history of stroke. Methods and analysis This prospective, randomised, open-label trial with blinded endpoint adjudication aimed to evaluate the efficacy of long-term home-based ECG monitoring for AF detection and stroke prevention in a 24-month period. Patients aged >18 years with a history of ischaemic stroke will be stratified according to the time from the index ischaemic stroke: <1, 1–3 and >3 years and then randomised in 1:1 to (1) home-based AF screening an...
Source: BMJ Open - July 15, 2022 Category: General Medicine Authors: Wong, C. K., Hai, J. J., Lau, Y.-M., Zhou, M., LUI, H.-W., Lau, K. K., Chan, K.-H., Mok, T. M., Liu, Y., Feng, Y., Tan, N., Tam, W.-C., Tam, K.-C., Feng, X., Zuo, M.-L., Yin, L.-X., Tan, J., Zhang, W.-J., Jiang, X., Huang, X., Ye, J., Liang, Y., Jiang, W. Tags: Open access, Cardiovascular medicine Source Type: research

Association of cognitive reserve with stroke outcome: a protocol for a systematic review
Introduction The concept of cognitive reserve (CR) was introduced to account for individual differences in the clinical manifestation of neurodegenerative diseases. Though several mechanisms and risk factors are shared between neurodegeneration and stroke, the effect of CR on poststroke functional outcome has been poorly addressed. This systematic review aims to synthesise the available research evidence on the association of CR with stroke outcome, in order to implement the understanding of interindividual variability in stroke outcome and to improve its prediction. Methods and analysis Cochrane Library, Embase, PubMed, ...
Source: BMJ Open - July 8, 2022 Category: General Medicine Authors: Gallucci, L., Umarova, R. M. Tags: Open access, Neurology Source Type: research

Association between reported work in cold environments and stroke occurrence in the CONSTANCES cohort: a prospective study
Conclusions This study did not reveal a significant excess risk of stroke for occupational exposures to low temperatures. Further studies are needed to better assess the effect of preventive measures and very low temperature on occurrence of cardiovascular diseases.
Source: BMJ Open - July 6, 2022 Category: General Medicine Authors: Fadel, M., Sembajwe, G., Tripodi, D., Bonneterre, V., Leclerc, A., Roquelaure, Y., Petit, A., Descatha, A. Tags: Open access, Occupational and environmental medicine Source Type: research

Effects of a social participation-focused virtual reality intervention for community-dwelling stroke survivors with physical disabilities: a randomised controlled trial protocol
Introduction Studies show that stroke survivors encounter physical and psychological limitations that restrict their participation in social and community activities. Systematic reviews have yielded inconclusive evidence regarding the effectiveness of different interventions intended to support stroke survivors’ social participation. Recent advances in virtual reality technology may offer promising solutions, although the optimal approach to enhance social participation among stroke survivors is yet to be determined. This trial aims to develop and evaluate the effectiveness of a social participation-focused virtual r...
Source: BMJ Open - July 5, 2022 Category: General Medicine Authors: Chau, J. P. C., Lo, S. H. S., Lau, A. Y. L., Lee, V. W. Y., Choi, K. C., Kwok, E. C. F., Thompson, D. R. Tags: Open access, Rehabilitation medicine Source Type: research

Feedback of aggregate patient-reported outcomes (PROs) data to clinicians and hospital end users: findings from an Australian codesign workshop process
Conclusions Our research provides guidance on PROs reporting for optimising data interpretation and comparing hospital performance.
Source: BMJ Open - July 1, 2022 Category: General Medicine Authors: Ryan, O. F., Hancock, S. L., Marion, V., Kelly, P., Kilkenny, M. F., Clissold, B., Gunzburg, P., Cooke, S., Guy, L., Sanders, L., Breen, S., Cadilhac, D. A. Tags: Open access, Health services research Source Type: research

Risk factors for fear of falling in stroke patients: a systematic review and meta-analysis
Conclusion This meta-analysis indicated that female population, impaired balance ability, lower mobility, history of falls and walking aid in patients with stroke might be at greater risk for FoF. Future studies are recommended to determine other risk factors specific to patients with stroke.
Source: BMJ Open - June 30, 2022 Category: General Medicine Authors: Xie, Q., Pei, J., Gou, L., Zhang, Y., Zhong, J., Su, Y., Wang, X., Ma, L., Dou, X. Tags: Open access, Geriatric medicine Source Type: research

Effects of whole-body vibration training on lower limb motor function and neural plasticity in patients with stroke: protocol for a randomised controlled clinical trial
This study has been approved by the Shanghai University of Sport Research Ethics Committee (102772021RT067) and will provide data on the effects of WBVT relative to RRT in terms of the improvement of stroke patients’ lower limb motor function and neural plasticity. The results of this study will be disseminated via publications in peer-reviewed journals and presentations at international conference. Trial registration number ChiCTR2200055143.
Source: BMJ Open - June 28, 2022 Category: General Medicine Authors: Zhang, M., Wei, J., Wu, X. Tags: Open access, Sports and exercise medicine Source Type: research

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials
Introduction Inflammation is emerging as an important risk factor for atherosclerotic cardiovascular disease and has been a recent target for many novel therapeutic agents. However, comparative evidence regarding efficacy of these anti-inflammatory treatment options is currently lacking. Methods and analysis This systematic review will include randomised controlled trials evaluating the effect of anti-inflammatory agents on cardiovascular outcomes in patients with known cardiovascular disease. Studies will be retrieved from Medline, Embase, the Cochrane Central Register of Controlled Trials, as well as clinical trial regi...
Source: BMJ Open - June 27, 2022 Category: General Medicine Authors: Boczar, K. E., Shin, S., Bezzina, K. A., Geejo, A., Pearson, A. L., Shahab, S., Fehlmann, C. A., Visintini, S., Beanlands, R., Wells, G. A. Tags: Open access, Cardiovascular medicine Source Type: research

Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China
Conclusion Young adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. Compared with older adults, young adults may had better in-hospital outcomes.
Source: BMJ Open - June 24, 2022 Category: General Medicine Authors: Wang, H.-Y., Gu, H.-Q., Zhou, Q., Jiang, Y.-Y., Yang, X., Wang, C.-J., Zhao, X.-Q., Wang, Y.-L., Liu, L.-P., Meng, X., Li, H., Liu, C., Li, Z.-X., Wang, Y.-J., Jiang, Y. Tags: Open access, Neurology Source Type: research