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Source: Heart Rhythm
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Total 406 results found since Jan 2013.
Po-620-04 intra-operative findings with massive device-related thrombus after percutaneous left atrial appendage closure: mechanistic insights
Left atrial appendage closure (LAAC) devices are an alternative to antithrombotic therapy for stroke prevention in high-risk patients with atrial fibrillation who are not candidates for systemic anticoagulation. However, device related thrombus (DRT) has an observed incidence of ∼4% after LAAC. The mechanism of massive thrombus formation remains incompletely understood.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Kashif Malik, Rong Bai, Damir Vukomanovic, Alicia Taase, Eleanor Kitchell, Rinku Skaria, Roderick Tung, Kenith Fang, Michael S. Zawaneh Source Type: research
Po-703-07 improved left ventricular ejection fraction and stroke volume with his bundle pacing are associated with higher magnitudes of global longitudinal and circumferential strains
In recently reported clinical studies, His bundle pacing (HBP) improved cardiac function in patients with pre-existing heart failure. The effect of HBP vs RBP on global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in the absence of pre-existing heart failure has not yet been explored.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Muhammad Shuja Khan, Annie Hirahara, Yuki Ishidoya, Ravi Ranjan, Derek J. Dosdall Source Type: research
Po-701-04 outcomes of left atrial appendage closure in patients with atrial fibrillation and end-stage renal disease on dialysis
Oral anticoagulation (OAC) therapy is the mainstay of treatment for stroke-risk reduction in patients with atrial fibrillation (AF). However, OAC use in patients with end-stage renal disease (ESRD) on dialysis is associated with a significantly increased risk of bleeding and an uncertain benefit in stroke reduction. In these patients, left atrial appendage closure (LAAC) could be alternative.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Jorge Romero, Juan C. Diaz, Sutopa Purkayastha, Jorge Marin, Julian M. Aristizabal, Daniel Rodriguez, Isabella Alviz, Mauricio Duque, Mohamed Gabr, Maria Gamero, Jose Matias, Marta Lorente-Ros, Luis Ernesto Cerna, Dhanunjaya R. Lakkireddy, Rishi Charate, Source Type: research
Po-701-01 nine month readmission rates and clinical outcomes of anticoagulation versus watchman device in octogenarians
Atrial Fibrillation (AF), the most common arrhythmia in older adults, is fraught with an increased risk of stroke. Studies which have demonstrated non-inferiority of Left atrial appendage occlusion (LAAO) with a watchman device compared to oral anticoagulation for stroke risk reduction in AF did not include patients greater than 80 years of age, making it difficult to generalize these results to this population.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Varun Victor, Mahmoud Khalil, Dilanthy Annappah, Ahmed Mohamed, Kirolos Barssoum Source Type: research
Po-699-03 ischemic stroke risk correlates with degree of left atrial fibrosis in atrial fibrillation patients
Increasing data support a causal relationship between left atrial (LA) remodeling and ischemic stroke (IS) risk in atrial fibrillation (AF) patients.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: LILAS DAGHER, Abdel Hadi El Hajjar, Mario Mekhael, Charbel Noujaim, Tarek ayoub, Dan L. LI, Chan Ho Lim, Nassir F. Marrouche Source Type: research
Po-697-02 impact of left atrial appendage stump on arrhythmogenicity and stroke risk after atri-clip in patients with persistent atrial fibrillation
Surgical left atrial appendage occlusion (LAAO) with an atrial clip (Atricure) is frequently performed for stroke prophylaxis in patients with atrial fibrillation (AF). Scant data exist for arrhythmogenicity and thromboembolic risk with the residual LAA stump.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Naga Venkata Krishna Chand Pothineni, Adnan Ahmed, Rishi Charate, Jalaj Garg, ahmed romeya, Domenico G. Della Rocca, Sanghamitra Mohanty, Luigi Di Biase, Rakesh Gopinathannair, Amin Al-Ahmad, Andrea Natale, Dhanunjaya R. Lakkireddy Source Type: research
Po-639-04 watchman vs amulet left atrial appendage occluder for stroke prophylaxis
Left atrial appendage Occlusion (LAAO) is an alternative to oral anticoagulation to reduce stroke risk in patients with non-valvular atrial fibrillation (NVAF).
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Jalaj Garg, Kuldeep Bharat Shah, Mohit K. Turagam, Rahul Bhardwaj, Tahmeed Contractor, Ravi Mandapati, Dhanunjaya R. Lakkireddy Source Type: research
Po-639-03 3d mapping facilitated, intra-cardiac echocardiography (ice) guided left atrial appendage occlusion (laao) is feasible and safe, providing similar efficacy with less personnel than transesophageal echocardiography (tee) guided procedures
Left atrial appendage occlusion (LAAO) provides an alternative for stroke prevention in patients with atrial fibrillation who cannot be safely anticoagulated long-term. WATCHMAN FLX placement was described, and is traditionally performed, with transesophageal echocardiography (TEE) guidance under general anesthesia (GA). The implanting physician, echocardiography team, and anesthesia team must all be present, complicating coordination and scheduling. The use of intracardiac echocardiography (ICE) with 3D mapping guidance in place of TEE for LAAO procedures can eliminate the need for additional personnel.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Iva Minga, Mark D. Metzl, Jonathan Rosenberg, Jose Nazari Source Type: research
Po-718-03 identifying and characterizing patients with atrial fibrillation and elevated thromboembolic risk who are not appropriately anticoagulated
Atrial fibrillation (AF) is the leading cause of stroke, which can be reduced by 70% with appropriate use of anticoagulation therapy. Nationally, appropriate anticoagulation rates for patients with AF with elevated thromboembolic risk are as low as 50% even across the highest CHADS2VASC score cohorts. Understanding anticoagulation fallout rates among gender, ethnicity, and socioeconomic status is an important first step towards decreasing the risk of thromboembolic events.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Sushmita Malik, Rachel Huai-En Chang, Shanshan Gustafson, Yonas Tamrat, Natalia Berry Source Type: research
Po-717-05 prophylactic and preventive radiofrequency septal ablation to reduce the possibility of left ventricular outflow tract obstruction post-mitral valve replacement
The patients who have severe mitral annulus calcification leading severe mitral stenosis often are eldery and have comorbidities which increase surgical risk of stroke, embolization, and bleeding complications.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Natchayathipk Kittichamroen, Atul Verma Source Type: research
Po-716-08 real world clinical outcomes of left atrial appendage occlusion device in the octogenarian and nonagenarian patients
Few trials evaluated real world clinical outcomes in patients with atrial fibrillation receiving the Watchman device for left atrial appendage closure. In the recent Ewolution trial, mean age of patients was 73.4 + 8 years. Although few patients> 80 years were included, the safety and efficacy in terms of clinical outcomes of stroke, bleeding and mortality in the octogenarian and nonagenarian population specifically has not been reported in real world setting.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Javier Amione Guerra, Justin Haloot, Ahmed Almomani, David N. Pederson, Jayasree Pillarisetti Source Type: research
Po-716-07 is cha2ds2vasc score useful for predicting the risk of stroke in patients with atrial fibrillation and cancer? : a single-center observational analysis
Patients with active cancer were historically excluded from clinical trials validating the CHA2DS2VASc score for stroke prediction in atrial fibrillation (AF). Limited data have questioned the predictive value of the score in patients with cancer and AF, underscoring the need for more personalized scores for prediction of stroke in these patients.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Udhayvir S. Grewal, Mohammad Bhuiyan, Nachiket Madhav APTE, Parinita A. Dherange, Paari Dominic Source Type: research
Po-716-02 short term readmission rates and clinical outcomes of anticoagulation versus watchman device in octogenarians
Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia with prevalence increasing with age. Left atrial appendage occlusion (LAAO) with watchman device has been found to be noninferior to oral anticoagulation for long-term stroke risk reduction in patients with AF. Patients greater than 80 years of age have been underrepresented in most of these trials making application of findings challenging in this subset of patients.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Varun Victor, Mahmoud Khalil, Ahmed Mohamed, Kirolos Barssoum Source Type: research
Po-713-05 ischemic stroke after prophylaxis with left atrial appendage closure vs non-warfarin oral anticoagulants: a “real-world” multicenter comparison of stroke severity
In randomized trials, strokes occurring in patients who have received left atrial appendage closure (LAAC) devices have been less severe than in patients receiving warfarin prophylaxis - an observation thought related to warfarin ’s higher rate of hemorrhagic stroke (which are known to have worse outcomes). Similar stroke rates have been described with LAAC vs NOACs (non-warfarin oral anticoagulants), but the low hemorrhagic stroke rate of NOACs raises the question of stroke severity between these two therapies.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Mohit K. Turagam, Iwanari Kawamura, Domenico G. Della Rocca, Pavel Hala, Thomas Flautt, Deji Adedokun, Moritoshi Funasako, Daniel Ross Musikantow, Srinivas R. Dukkipati, David H. Yoo, Petr Neuzil, Devi G. Nair, Douglas N. Gibson, Miguel Valderrabano, Andr Source Type: research
Po-626-03 preclinical safety of adkcnh2-g628s for post-op af
Post-operative atrial fibrillation (POAF) occurs in 30% of cardiac surgeries, increasing risk of stroke, MI, and death. We propose gene therapy with an adenovirus encoding the G628S mutation of KCNH2 (AdKCNH2-G628S) to prevent POAF. We have reported preclinical efficacy in pigs.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: J. Kevin Donahue, David D. McManus Source Type: research
