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Source: Heart Rhythm
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Total 406 results found since Jan 2013.
Blocking interleukin-6 Trans-Signaling in AF: Promises and Challenges
Atrial fibrillation (AF) stands as the most prevalent cardiovascular disease, posing significant risks of stroke, heart failure, and other complications that contribute to morbidity and mortality. While traditionally research on AF has primarily focused on electrophysiological components like ionic currents and the Ca2+ handling system, treatment strategies have mainly revolved around the rate-limiting beta-blockers and Ca2+ channel blockers, or rhythm-control methods such as cardioversion, antiarrhythmics, and catheter ablation.
Source: Heart Rhythm - September 9, 2023 Category: Cardiology Authors: Enrique Martinez, Na Li Source Type: research
EP News Clinical
Kirchof and colleagues (N Engl J Med. 2003; epub Aug. 25: PMID: 37622677) conducted a, double-blind, double-dummy, randomized trial of patients> 65 years with device-detected atrial high-rate episodes (AHREs)> 6 minutes. Patients were randomized to edoxaban (E) or placebo (P). The primary efficacy outcome was a composite of cardiovascular death, stroke, or systemic embolism. The safety outcome was a composite of death from any cause or major bleeding. Overall, 2536 patients were randomized, including 1270 to E and 1266 to P.
Source: Heart Rhythm - September 7, 2023 Category: Cardiology Authors: N. A. Mark Estes Source Type: research
EP News: Clinical
Kirchof et al (N Engl J Med August 25, 2003; https://doi.org/10.1056/NEJMoa2303062, PMID 37622677) conducted a double-blind, double-dummy, randomized trial of patients 65 years and older with device-detected atrial high-rate episodes lasting for ≥6 minutes. Patients were randomized to edoxaban (E) or place bo (P). The primary efficacy outcome was a composite of cardiovascular death, stroke, or systemic embolism. The safety outcome was a composite of death from any cause or major bleeding. Overall, 2536 patients were randomized, including 1270 to E and 1266 to P.
Source: Heart Rhythm - September 7, 2023 Category: Cardiology Authors: N.A. Mark Estes Tags: EP NEWS Source Type: research
Lb-456091-2 dynamic data driven management of atrial fibrillation using implantable cardiac monitors – the monitor af study
Management of atrial fibrillation (AF) is often complex and dynamic. Clinical decisions related to initiation of rate control, rhythm control strategies, stroke prophylaxis measures depend on the assessment of the presence and the burden of AF. Assessment of therapy outcomes and withdrawl of drugs and anticoagulation are guided by AF monitoring. Implantable cardiac monitors (ICM) are excellent tools to detect and monitor AF burden in a dynamic fashion. We prospectively studied if the presence of an ICM impacts the management of AF and there by clinical outcomes.
Source: Heart Rhythm - May 16, 2023 Category: Cardiology Authors: Dhanunjaya R. Lakkireddy, Jalaj Garg, Adnan Ahmed, Danish Bawa, Rajesh Kabra, Douglas Darden, Rakesh Gopinathannair, Naga Venkata K. Pothineni, Poojita Shivamurthy, Scott Koerber, Peter H. Park, Chandrasekhar R. Vasamreddy, Rangarao V. Tummala, Donita Atk Source Type: research
EP News: Triaging AF Patients for Optimal Care
Atrial fibrillation (AF) is a major public health concern that affects millions of people worldwide. AF is associated with increasing health care costs and a higher risk of stroke with increasing comorbidities and age. Despite well-written guidelines for AF care, standardized management is lacking. Therein lies an opportunity to create AF centers of excellence (AF CoEs) with a patient-centered integrated focus and approach that can benefit patients and health care providers alike.
Source: Heart Rhythm - May 16, 2023 Category: Cardiology Authors: James Allred, Anne Marie Smith, John Catanzaro Source Type: research
EP News: Quality Improvement and Outcomes —Triaging AF Patients for Optimal Care
Atrial fibrillation (AF) is a major public health concern that affects millions of people worldwide. AF is associated with increasing health care costs and a higher risk of stroke with increasing comorbidities and age. Despite well-written guidelines for AF care, standardized management is lacking. Therein lies an opportunity to create AF centers of excellence (AF CoEs) with a patient-centered integrated focus and approach that can benefit patients and health care providers (physicians, nurse practitioners, physician assistants, nurses, pharmacists and technologists) alike.
Source: Heart Rhythm - May 16, 2023 Category: Cardiology Authors: James Allred, Anne Marie Smith, John Catanzaro Tags: EP News Source Type: research
Outcomes of Percutaneous Left Atrial Appendage Occlusion Device Implantation in Patients with Rheumatic Atrial Fibrillation
Patients with atrial fibrillation (AF) and rheumatic heart disease (RHD) disease have a 17-fold increased risk of stroke, and in comparison, those with AF without RHD have a 5-fold increased risk of stroke (1). However, the contemporary trials of pharmaceutical and device therapies have systematically excluded patients with AF and RHD. While Vitamin K antagonist remains the favored approach to mitigate stroke risk in patients with RHD and AF, the optimal strategy for preventing stroke in patients with RHD-associated AF who cannot tolerate oral anticoagulation therapy remains unknown (1).
Source: Heart Rhythm - May 12, 2023 Category: Cardiology Authors: Siddharth Agarwal, Muhammad Bilal Munir, Agam Bansal, Christopher V. DeSimone, Abhishek Deshmukh, Mohamad Alkhouli, Zain Ul Abideen Asad Source Type: research
Po-02-192 new onset, recurrence and progression of atrial fibrillation after cardiac surgery during 2.5 years of continuous rhythm monitoring
Atrial fibrillation (AF) in the early postoperative phase (POAF) is a frequent complication after cardiac surgery which is also associated with late AF-recurrences. However, it is unknown how POAF-burden (percentage of time in AF) progresses in the time following surgery. Recent studies suggested that AF-burden is associated with increased risk of stroke and therefore identifying factors associated with a higher POAF-burden is desirable.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Michal Kawczynski, Martijn D. Gilbers, Stef Zeemering, Aaron Isaacs, Jos Maessen, Sander Verheule, Elham Bidar, Ulrich Schotten Source Type: research
Po-02-165 cost implications of adherence to guideline-recommended anticoagulation among patients with atrial fibrillation at high risk of stroke
Caring for patients with AF is expensive. Estimated costs account for up to 3% of total annual heath care expenditure in many developed nations. Due to an aging population, the clinical and economic burden is expected to increase over the next decade. There are limited contemporary economic data to facilitate the development of cost-efficient strategies for improving the quality of AF care.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Brennan Ballantyne, Amity Quinn, Flora Au, Stephen B. Wilton, Derek Chew Source Type: research
Po-02-140 central retinal artery occlusion: a systematic review and meta-analysis for the risk of new-onset atrial fibrillation and stroke
Central retinal artery occlusion (CRAO) is a devastating event and atrial fibrillation (AF) is a recognized cause that may not be present at the time of the event.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Sotirios Nedios, Prakash Gupta, Rita Anjos, Ana Miguel, Jonathan Salangsang, Borislav Dinov, Nikolaos Dagres, Gerhard Hindricks, Andreas Bollmann Source Type: research
Po-02-134 real world clinical management after surgical left atrial appendage excision
Surgical left atrial appendage (LAA) closure is an increasingly utilized approach to mitigate the risk of cardioembolic stroke in patients with atrial fibrillation (AF). Optimal stroke prevention management after surgical LAA management with respect to imaging and continuation of oral anticoagulation (OAC) is not well understood.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Karanpreet Dhaliwal, Matthew Singleton, Karl Richardson, Lauren Ehrhardt-Humbert, David Coffman, Prashant D. Bhave Source Type: research
Po-05-218 atrial myopathy forms the substrate for ischemic stroke in patients without atrial fibrillation: secondary analysis of topcat trial.
Around 25% of all ischemic strokes do not have an etiology despite a complete standardized diagnostic workup. Recent studies emphasized the effect of atrial dysfunction on arrhythmogenesis and thrombogenesis. At present, there is a lack of a direct link between atrial myopathy and ischemic stroke independently of atrial fibrillation (AF).
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Kassem Farhat, Khaled Elkholey, Stavros Stavrakis Source Type: research
Po-05-197 association of genetic risk of atrial fibrillation and dementia
Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. However, precise mechanism of this association is not well-known and studies that examine the association of genetic susceptibility of AF and dementia is scarce.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Dongmin Kim, Juntae Kim, Eunsun Jang, Daehoon Kim, Hee Tae Yu, Myung-Yong Lee, Pil-Sung Yang, Boyoung Joung Source Type: research
Po-05-185 prediction and risk of atrial fibrillation in patients with hypertrophic cardiomyopathy: a danish nationwide cohort study
Hypertrophic cardiomyopathy (HCM) can be associated with serious complications such as heart failure, atrial fibrillation (AF) and sudden cardiac death. The treatment of AF in HCM patients can be challenging since AF often aggravates symptoms and increases the risk of stroke. Little is known on which factors contribute to the development of AF in these patients.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Christopher Z örner, Jannik L. Pallisgaard, Anne-Marie Schjerning, Morten K. Jensen, Jacob Tønnesen, Lise D. Vestergaard, Peter Vibe Rasmussen, Gunnar Gislason, Morten L. Hansen Source Type: research
Po-05-169 ventricular scar by cardiac mri is a predictor of atrial fibrillation in hypertrophic cardiomyopathy
Atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM) increases risk of stroke and mortality. The reported prevalence of AF in HCM ranges from 18% to 28%, which is higher than the general population; even after accounting for traditional risk factors including obesity, hypertension, and age. Several factors increase risk of AF in HCM including left atrial size and the presence of ventricular obstruction. However, there is paucity of data correlating ventricular late gadolinium enhancement (LGE) to the incidence of AF in HCM.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Joseph Banno, David Fermin, Dana Marsy, Nabin Manandhar Shrestha, Richard McNamara, Jeffrey Decker, Alfred J. Albano, Jose Tan, Laura Franey, Wissam Abdallah, Christopher Madison, Renzo Loyaga Rendon, Nagib T. Chalfoun Source Type: research
