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Source: Heart Rhythm

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Total 406 results found since Jan 2013.

Po-01-167 efficacy of botulinum toxin type a (agn-151607) for the prevention of postoperative atrial fibrillation in cardiac surgery patients: atrial fibrillation and anticoagulation results from the phase 2 nova study
Oral anticoagulation reduces the risk of stroke but also increases the risk of bleeding. Prevention of post-operative atrial fibrillation (POAF) could result in a lower burden of oral anticoagulation and bleeding events. AGN-151607 has been proposed to prevent POAF and its safety/efficacy was tested in a multicenter randomized trial.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Nathan Waldron, Alexandra OSullivan, Jonathan P. Piccini, Matthew Romano, Pierre Voisine, Wilson Titanji, Richard Leaback, William Ferguson, Jonathan S. Steinberg Source Type: research

Po-01-141 safety and efficacy of oral anticoagulant in patients undergoing ventricular tachycardia ablation
Periprocedural stroke is a devastating complication of any left-sided electrophysiological procedure. Limited data exist regarding post-Ventricular tachycardia (VT) ablation antiplatelet or anticoagulation strategy – often extrapolated from clinical experience with catheter ablation for atrial fibrillation.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Jakrin Kewcharoen, Sohaib Basharat, Kuldeep B. Shah, Ravi Mandapati, Rahul Bhardwaj, Mohit K. Turagam, Tahmeed Contractor, Dhanunjaya R. Lakkireddy, Jalaj Garg Source Type: research

Po-01-140 atrial fibrillation and septic shock: a five-year retrospective observational study of anticoagulation usage, bleeding and stroke rates
Anticoagulation (AC) for atrial fibrillation (AF) is a cornerstone of management, and the benefit of mitigating stroke risk is accompanied by an increased risk of bleeding. The risk and benefit of AC in septic shock remains unclear as this disruptive hyperinflammatory state leads to multi-organ dysfunction, which can include coagulopathies.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Jonathan Na, Joanne Moon, Sahitya Allam, Maria Abraham, Kevin Chen, Ethan Kotloff, Yash Desai, Simin Hossain, Christopher Messner, Elnaz Esmati, Thomas Kutner, Gregory Norcross, James Childress, Paul Han, Ian Welch, Michael Sokolow, Libin Wang, Vincent Se Source Type: research

Po-01-210 stroke risk is identified by slow blood flow and stagnant blood particles in the left atrium
Atrial fibrillation (AF) is the most common type of arrhythmia, causing irregular contraction patterns in the atrial chambers. This rhythm disorder may result in stagnant flow, leading to the formation of blood clots, especially in the left atrial appendage (LAA), and causing a thrombotic stroke. Current stroke risk assessment in AF patients is done using CHADS2 or CHA2 DS2 –VASc scores, which are based on selected clinical characteristics, without accounting for potential risk factors such as LAA thrombi formation.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Alberto Zingaro, Zan Ahmad, Carolyna Yamamoto Alves Pinto, Kensuke Sakata, Eugene G. Kholmovski, Luca Dede', Alfio Quarteroni, Natalia A. Trayanova Source Type: research

En-452414-3 predictors of ischemic stroke in the young: sleep apnea, race and risk factors beyond af and chads2vasc
Risk factors for stroke beyond CHADS2VASc and atrial fibrillation (AF) are not well established.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Brototo Deb, Sunil K. Vasireddi, Neal K. Bhatia, Albert J. Rogers, Paul Clopton, Sanjiv M. Narayan Source Type: research

Dh-452784-2 identifying atrial fibrillation with sinus rhythm electrocardiogram using artificial intelligence in embolic stroke with undetermined source
Previous studies have demonstrated acceptable ranges of accuracy of artificial intelligence (AI) algorithms for identifying patients with paroxysmal atrial fibrillation (AF) based on their sinus rhythm electrocardiograms (ECGs). However, none of them has been validated in patients with embolic stroke with undetermined source (ESUS) in which thorough AF screening is required.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Ji Hyun Lee, Youngjin Cho, Joonghee Kim Source Type: research

Ce-452772-4 delayed detection of and intervention for incident af in hospitalized patients is common and consequential
Incident atrial fibrillation (AF) affects c.10% of hospitalized patients. Early AF management mitigates risk of complications (e.g. stroke, heart failure, care escalation) yet recognition and intervention is sub-optimal. Prior work here showed a median 1.5 day delay from automated algorithmic AF detection to clinical action in the ICU.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Daniel Soto, Nicholas Van Dyke, Nick Prinz, Randall Moorman, Oliver J. Monfredi Source Type: research

Ce-452772-3 self-pulse exam for atrial fibrillation screening: a randomized controlled trial
Atrial fibrillation (AF), the most commonly treated cardiac arrhythmia, is associated with significant morbidity including the potential for stroke. Because AF is often asymptomatic, there is growing interest in AF screening. Trials of AF screening using external monitors, smartwatches, or other personal electronic devices have shown that screening increases detection of AF. Due to the cost and low yield of screening with insufficient evidence of clinical benefit, the US Preventative Services Task Force has not recommended comprehensive screening for AF at the current time.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Benjamin Chilcutt, Taylor C. Bazemore, Tiffany Armbruster, Ari Becker, Wanting Jin, Quefeng Li, Anil K. Gehi Source Type: research

Ce-452778-1 left atrial mechanical dysfunction and the incidence of atrial fibrillation within 1 year of embolic stroke of unknown source
Atrial fibrillation (AF) is detected in a significant proportion of patients with embolic stroke of unkown source (ESUS) on subsequent cardiac monitoring and represents an indication for anticoagulation to prevent future stroke in these patients. Left atrial mechanical dysfunction often precedes development of atrial fibrillation and may represent an upstream marker which can readily be assessed at the point of care to inform decisions about future stroke prevention in people with ESUS.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Ravi S. Shah, Joseph Raco, Ryan Williams, Michael Farbaniec, Nathaniel D. McConkey, Kevin J. Mills, ankit maheshwari Source Type: research

Ci-452768-1 impact of new-onset atrial fibrillation detected by cardiac implantable electronic devices on cardioembolic stroke events
The association between atrial fibrillation (AF) detected by implanted cardiac implantable electronic devices (CIEDs) and the incidence of cardioembolic stroke events has been reported. However, the cut-off value of new-onset AF duration detected by CIEDs for cardioembolic stroke is still unknown. In previous studies regarding the cut-off value of AF duration, patients who had a history of AF or had received anticoagulant therapies were also included. Therefore, the solo effect of AF on the risk of cardioembolic stroke cannot be reliably evaluated on these studies.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Miyo Nakano, Yusuke Kondo, Masahiro Nakano, Takatsugu Kajiyama, Ryo Ito, Mari Kitagawa, Toshinori Chiba, Satoko Ryuzaki, Yutaka Yoshino Source Type: research

Ce-452780-3 predictors of atrial fibrillation recurrence in cardiac and non-cardiac patients with post-operative atrial fibrillation
Post-operative atrial fibrillation (POAF) is new onset atrial fibrillation (AF) that occurs within 90 days of surgical procedure. Its underlying mechanism is believed to be related to factors such as inflammation, adrenergic surplus, infections and hypoxia. The predictors of AF recurrence in POAF population are not well defined. Establishing potential predictors of AF recurrence in POAF patients could help clinicians identify patients who are at increased risk of stroke and other complications.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Ayesha Shaik, Maciej Tysarowski, Sana Riaz, Karthik Gonuguntla, Jeffrey Mather, Adaya Weissler-Snir Source Type: research

Po-01-219 combination of early rhythm control and healthy lifestyle on the risk of stroke in elderly patients with new-onset atrial fibrillation: a korean nationwide population-based cohort study
Early rhythm control and lifestyle modification have both been associated with a lower risk of stroke in patients with atrial fibrillation (AF). However, the impact of early rhythm control strategy in combination with lifestyle modification on the risk of stroke is less clear in elderly population.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Woo-Hyun Lim, So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Seil Oh, Gregory Lip Source Type: research

Bs-452758-4 combined gene therapy approach targets parasympathetic signaling and oxidative stress to attenuate persistent atrial fibrillation development in a canine model
Atrial fibrillation (AF) is the most common arrhythmia, a major risk factor for stroke and is associated with substantial morbidity and mortality. Unfortunately, current pharmacological and interventional treatment approaches are suboptimal. Parasympathetic nervous system (PNS) activity upregulation and oxidative stress (OS), mainly generated by NADPH oxidase 2 (NOX2), have been shown as key players in AF induction and maintenance. A deeper understanding of these molecular mechanisms underlying AF and their interplay will be instrumental to the development of new, mechanism-targeted therapies for AF.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Aleksei Mikhailov, Azaria Panni, Anna Pfenniger, Shin Yoo, David Johnson, Wenwei Zhang, Markus Rottmann, William Marszalec, Asish Ghosh, Rod S. Passman, Bradley P. Knight, Rishi Arora Source Type: research

Po-01-197 the epidemiology of extracranial infarcts in a population-based cohort with atrial fibrillation
The epidemiology of Atrial Fibrillation (AF)-associated stroke is well-described. However, less is known about the epidemiology of AF-associated extracranial emboli, which may be inferred from the tissue infarcts observed.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Alexander P. Cabulong, Janet Tang, Thomas A. Dewland, Gregory M. Marcus Source Type: research

Po-01-196 minorities have greater long-term atrial fibrillation-free survival post ablation despite lower referral rates and higher incidence of baseline comorbidities
Significant differences in the incidence and management of atrial fibrillation (AF) have been observed based on patient sex and race. Women with AF tend to be older, have higher stroke/mortality risk, and receive catheter ablation less often than men, while racial minority patients paradoxically have lower prevalence of AF than nonminority patients despite a higher burden of traditional risk factors.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Michael Alston, Sana Ahmad, Elliot Wolf, Kristie Coleman, Stefanos Zafeiropoulos, Christopher Gasparis, Jonas Leavitt, Ari Zimmer, Laurence M. Epstein, Rajat Goyal, Stavros Mountantonakis Source Type: research