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Total 262 results found since Jan 2013.

Risk assessment in hypertrophic cardiomyopathy: contemporary guidelines hampered by insufficient evidence
If it were not for the great variability among individuals, medicine might as well be a science and not an art. (Sir William Osler, 1892) The sudden unexpected death of an individual at any age has a profound effect on the family and the wider community and this is particularly significant when it affects a young person. Hypertrophic cardiomyopathy remains one of the common causes of sudden cardiac death (SCD) in young individuals.1 In a cohort of 744 patients with hypertrophic cardiomyopathy from the USA and Italy, where 86 (12%) died over an 8 (SD±7) year period of follow-up, three main modes of death were identif...
Source: Heart - March 19, 2013 Category: Cardiology Authors: McKeown, P. P., Muir, A. R. Tags: Open access, Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Hypertension Editorials Source Type: research

Is C reactive protein expression affected by local microenvironment?
The role that inflammation plays on the vasculature has become fundamental in our understanding of the different steps underlying the development of coronary heart disease (CHD).1 Immunological-related inflammatory processes accompany all stages of atherosclerosis development, from the early formation of lesions in the arteries to the rupture of the atherosclerotic plaques, which leads to dramatic consequences such as myocardial infarction and stroke. In this light, the search of markers of inflammation that could help to predict and even to treat cardiovascular diseases has been the subject of intense investigation. C rea...
Source: Heart - March 19, 2013 Category: Cardiology Authors: Ummarino, D., Zeng, L. Tags: Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Editorials Source Type: research

Rivaroxaban and other novel anticoagulants for stroke prevention in atrial fibrillation: time to embrace the future
Atrial fibrillation (AF) is now said to be at epidemic proportions.1 Although symptoms and heart failure are two of the main reasons that patients with AF suffer from reduced quality of life, thromboembolic complications, particularly stroke, remain the major determinant of significant morbidity and mortality.2 Importantly, the risk of thromboembolism (TE) is completely irrespective of symptoms, and hence the sad fact that people continue to present with catastrophic stroke in AF with no prior history of its detection.3 Appropriate anticoagulation is imperative to reduce the TE/stroke risk. Numerous large scale studies hav...
Source: Heart - February 18, 2013 Category: Cardiology Authors: Rajappan, K. Tags: Drugs: cardiovascular system, Epidemiology Editorials Source Type: research

Arterial disease in chronic kidney disease
End stage renal disease is associated with a very high risk of premature cardiovascular death and morbidity. Early stage chronic kidney disease (CKD) is also associated with an increased frequency of cardiovascular events and is a common but poorly recognised and undertreated risk factor. Cardiovascular disease in CKD can be attributed to two distinct but overlapping pathological processes, namely atherosclerosis and arteriosclerosis. While the risk of athero-thrombotic events such as myocardial infarction is elevated, arteriosclerosis is the predominant pathophysiological process involving fibrosis and thickening of the m...
Source: Heart - February 18, 2013 Category: Cardiology Authors: Moody, W. E., Edwards, N. C., Chue, C. D., Ferro, C. J., Townend, J. N. Tags: Reviews Source Type: research

MR-proANP and MR-proADM for risk stratification of patients with acute chest pain
Conclusions MR-proADM and MR-proANP are predictors of future cardiovascular events in patients presenting with acute chest pain and might facilitate the choice of treatment in those patients complementary to established risk scores.
Source: Heart - February 18, 2013 Category: Cardiology Authors: Tzikas, S., Keller, T., Ojeda, F. M., Zeller, T., Wild, P. S., Lubos, E., Kunde, J., Baldus, S., Bickel, C., Lackner, K. J., Munzel, T. F., Blankenberg, S. Tags: Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Biomarkers and heart disease Source Type: research

Trends in cardiovascular mortality and hospitalisations, and potential contribution of inhospital case-fatality rates to changes in national mortality in the Czech Republic 1994-2009
Conclusions During the study period, the overall CVD hospitalisation rates remained high but inhospital CFR declined considerably. The improved case-fatality seems to have made a substantial contribution to the decline in the national CVD mortality, particularly for AMI and stroke.
Source: Heart - February 18, 2013 Category: Cardiology Authors: Davidkovova, H., Kysely, J., Kriz, B., Vojtisek, P., Bobak, M. Tags: Health policy, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology Source Type: research

Exercise-induced torsional dyssynchrony relates to impaired functional capacity in patients with heart failure and normal ejection fraction
Conclusions HFNEF involves exercise-induced torsional dyssynchrony in systole and diastole, which relates to LV hypertrophy as well as exercise capacity.
Source: Heart - January 25, 2013 Category: Cardiology Authors: Tan, Y. T., Wenzelburger, F. W., Sanderson, J. E., Leyva, F. Tags: Heart failure, Drugs: cardiovascular system, Echocardiography, Hypertension, Clinical diagnostic tests Source Type: research