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Total 262 results found since Jan 2013.

Heartbeat: knowledge gaps for non-bacterial thrombotic endocarditis
Non-bacterial thrombotic endocarditis (NBTE) contributes to adverse outcomes in patients with systemic inflammatory conditions, antiphospholipid syndrome or advanced malignancy (figure 1). Diagnosis is challenging and there is little data to guide prevention of adverse events, particularly stroke. In this issue of Heart, Quintero-Martinez and colleagues1 report the clinical characteristics and outcomes in 48 adults with NBTE identified at the Mayo Clinic over a 7 year period. Most patients (75%) were women with a mean age of 60 years and most cases were associated with malignancy (52%) or a systemic inflammatory disease (3...
Source: Heart - September 26, 2022 Category: Cardiology Authors: Otto, C. M. Tags: Highlights from this issue Source Type: research

Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis
Conclusions The beneficial effects of salt substitutes on blood pressure across geographies and populations were consistent. Blood pressure-mediated protective effects on clinical outcomes are likely to be generalisable across population subgroups and to countries worldwide. Trial registration number CRD42020161077.
Source: Heart - September 26, 2022 Category: Cardiology Authors: Yin, X., Rodgers, A., Perkovic, A., Huang, L., Li, K.-C., Yu, J., Wu, Y., Wu, J. H. Y., Marklund, M., Huffman, M. D., Miranda, J. J., Di Tanna, G. L., Labarthe, D., Elliott, P., Tian, M., Neal, B. Tags: Press releases Cardiac risk factors and prevention Source Type: research

Exercise oxygen pulse kinetics in patients with hypertrophic cardiomyopathy
Conclusion None of the frequently used CPET parameters, either as absolute values or dynamic relationships, were associated with LVOTO. Differently, an abnormal temporal behaviour of O2-pulse during exercise, which is strongly related to inadequate SV increase, correlates with reduced functional capacity (peak and anaerobic threshold VO2 and workload) and increased VE/VCO2 slope, identifying more advanced disease irrespectively of LVOTO.
Source: Heart - September 26, 2022 Category: Cardiology Authors: Mapelli, M., Romani, S., Magri, D., Merlo, M., Cittar, M., Mase, M., Muratori, M., Gallo, G., Sclafani, M., Carriere, C., Zaffalon, D., Salvioni, E., Mattavelli, I., Vignati, C., De Martino, F., Rovai, S., Autore, C., Sinagra, G., Agostoni, P. Tags: Heart failure and cardiomyopathies Source Type: research

Contemporary demographics, diagnostics and outcomes in non-bacterial thrombotic endocarditis
Conclusions NBTE was more prevalent in females and embolic complications were the most frequent clinical finding. Overall, patients with NBTE had a poor prognosis, particularly in those with lung cancer or metastatic tumours. Further studies in patients with NBTE are needed given its morbidity and mortality.
Source: Heart - September 26, 2022 Category: Cardiology Authors: Quintero-Martinez, J. A., Hindy, J.-R., El Zein, S., Michelena, H. I., Nkomo, V. T., DeSimone, D. C., Baddour, L. M. Tags: Valvular heart disease, Editor's choice Source Type: research

Pregnancy-related cardiovascular conditions and outcomes in a United States Medicaid population
Conclusion This US cohort of Medicaid-funded women have a high incidence of severe cardiovascular conditions during pregnancy. Cardiometabolic conditions of pregnancy conferred threefold higher odds of severe cardiovascular outcomes.
Source: Heart - September 12, 2022 Category: Cardiology Authors: Marschner, S., von Huben, A., Zaman, S., Reynolds, H. R., Lee, V., Choudhary, P., Mehta, L. S., Chow, C. K. Tags: Open access, Editor's choice Cardiac risk factors and prevention Source Type: research

Clinical outcomes in spontaneous coronary artery dissection
Conclusions In this large prospective cohort of patients with SCAD, prognosis was overall favourable, with events mainly driven by reinfarctions or unplanned revascularisations. History of hypothyroidism, proximal vessel involvement, type 2 IMH and DAPT at discharge were associated with MACCE. Trial registration number NCT03607981.
Source: Heart - September 12, 2022 Category: Cardiology Authors: Garcia-Guimaraes, M., Masotti, M., Sanz-Ruiz, R., Macaya, F., Roura, G., Nogales, J. M., Tizon-Marcos, H., Velazquez-Martin, M., Veiga, G., Flores-Rios, X., Abdul-Jawad Altisent, O., Jimenez-Kockar, M., Camacho-Freire, S., Moreu, J., Ojeda, S., Santos-Mar Tags: Coronary artery disease Source Type: research

Inter-racial differences in patients undergoing transcatheter aortic valve implantation
Conclusions There were significant differences in baseline and procedural factors among Asian and non-Asian patients who underwent TAVI. Observed inter-racial differences in clinical outcomes were largely explained by baseline differences in clinical, anatomical and procedural factors. Trial registration number NCT03826264 (https://wwwclinicaltrialsgov).
Source: Heart - September 12, 2022 Category: Cardiology Authors: Kang, D.-Y., Ahn, J.-M., Kim, J. B., Yeung, A., Nishi, T., Fearon, W., Cantey, E. P., Flaherty, J. D., Davidson, C. J., Malaisrie, S. C., Park, S. Y., Yun, S.-C., Ko, E., Park, H., Lee, S.-A., Kim, D.-H., Kim, H. J., Kim, J. B., Choo, S. J., Park, D.-W., Tags: Valvular heart disease Source Type: research

Heartbeat: cardiovascular maternal health and disparities in clinical outcomes
Cardiovascular disease continues to account for a high proportion of pregnancy-related deaths in women in the USA. In addition to pre-existing heart disease, gestational hypertension and diabetes, as well as pre-eclampsia and eclampsia, are associated with an increased risk of adverse cardiovascular outcomes both in the short and long-term. In this issue of Heart, Marschner and colleagues1 report an incidence of cardiometabolic conditions (hypertensive disease and diabetes) of 224.3 (95% CI 221.3 to 227.3) per 1000 births among 74 510 women, mean age 26.4 years (SD 5.5) in a cross-sectional study of Medicare patients from ...
Source: Heart - September 12, 2022 Category: Cardiology Authors: Otto, C. M. Tags: Highlights from this issue Source Type: research

Sex-specific differences in adverse outcome events among patients with atrial fibrillation
Conclusion In this large study of patients with established AF, women had a lower risk of death than men, but there were no sex-specific differences in other adverse outcomes.
Source: Heart - August 25, 2022 Category: Cardiology Authors: Evers-Dörpfeld, S., Aeschbacher, S., Hennings, E., Eken, C., Coslovsky, M., Rodondi, N., Beer, J. H., Moschovitis, G., Ammann, P., Kobza, R., Ceylan, S., Krempke, M., Meyer-Zürn, C. S., Moutzouri, E., Springer, A., Sticherling, C., Bonati, Tags: Arrhythmias and sudden death Source Type: research

A strange way of breathing in a patient with advanced systolic heart failure
Clinical introduction A man in his 70s with a left bundle branch block and advanced valvular systolic heart failure (HF) presented with a subacute HF and low cardiac output (CO) (peripheral hypoperfusion, high lactic levels, symptomatic hypotension). Echocardiography confirmed severe reduction in left ventricular ejection fraction, global longitudinal strain and stroke volume, as assessed by outflow tract pulse Doppler. Acute HF therapy with dobutamine and levosimendan was started, leading to progressive haemodynamic improvement. After suspension of inotropes, under conditions of haemodynamic stability, a cardiopulmonary r...
Source: Heart - August 11, 2022 Category: Cardiology Authors: Mapelli, M., Salvioni, E., Agostoni, P. Tags: Image challenges Source Type: research

BMJ Rapid Recommendations on use of proprotein convertase subtilisin/kexin 9 inhibitors and ezetimibe to reduce cardiovascular risk
The new BMJ Rapid Recommendations addressed the following question: should we add another lipid-lowering drug in adults with low-density lipoprotein-cholesterol (LDL-C) over 1.8 mmol/L using a maximal dose of statins or intolerant to statins?1 Why is this question important? Both proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe have been shown to reduce LDL-C by approximately 60% and approximately 20%, respectively, and correspondingly may reduce major adverse cardiovascular events (MACE), including all-cause death, cardiovascular death, myocardial infarction (MI) and stroke. However, the bene...
Source: Heart - July 27, 2022 Category: Cardiology Authors: White, H. D. Tags: Editorials Source Type: research

Air pollution and cardiovascular disease: the Paul Wood Lecture, British Cardiovascular Society 2021
Air pollution is associated with up to 8.8 million excess deaths worldwide each year and is a major contributor to the global burden of disease. Cardiovascular conditions are the predominant cause for air pollution-related deaths and there is an urgent need to address the silent pandemic of air pollution on cardiovascular health. Air pollution exposure is associated with acute events like acute coronary syndrome and stroke, and with chronic conditions, such as atherosclerosis and heart failure. Several potential mechanisms have been proposed that link particle inhalation to cardiovascular disease including oxidative stress...
Source: Heart - July 27, 2022 Category: Cardiology Authors: Joshi, S. S., Miller, M. R., Newby, D. E. Tags: Review articles Reviews Source Type: research

Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Conclusions In hospitalised patients with COVID-19, cardiovascular complications or death impacts just under half of all patients, with the highest risk in those of South Asian or Black ethnicity and in patients with cardiometabolic multimorbidity.
Source: Heart - July 13, 2022 Category: Cardiology Authors: Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., Chudasama, Y. V., Rowlands, A. V., Davies, M. J., McCann, G. P., Banerjee, A., Lam, C. S. P., Docherty, A. B., Openshaw, P. J., Baillie, J. K., Semple, M. G., Lawson, C. A., Khunt Tags: Open access Cardiac risk factors and prevention Source Type: research

Atrial fibrillation following transcatheter atrial septal defect closure: a systematic review and meta-analysis
Conclusions The incidence of new-onset AFi/AFl is relatively low following transcatheter closure of secundum ASDs. The rate of de novo AFi/AFl, however, was significantly higher in elderly patients. Shorter follow-up time was associated with a higher reported incidence of AFi/AFl.
Source: Heart - July 13, 2022 Category: Cardiology Authors: Himelfarb, J. D., Shulman, H., Olesovsky, C. J., Rumman, R. K., Oliva, L., Friedland, J., Farrell, A., Huszti, E., Horlick, E., Abrahamyan, L. Tags: Congenital heart disease Source Type: research

Management and outcomes of patients with left atrial appendage thrombus prior to percutaneous closure
Conclusion In the presence of LAA thrombus, IAT was the initial management strategy in half of our cohort, with initial thrombus resolution in 60% of these, but with a relatively high bleeding rate (~10%). Direct LAAC was feasible, with high procedural success and absence of periprocedural embolic complications. However, a high rate of device-related thrombosis was detected during follow-up.
Source: Heart - June 24, 2022 Category: Cardiology Authors: Marroquin, L., Tirado-Conte, G., Pracon, R., Streb, W., Gutierrez, H., Boccuzzi, G., Arzamendi-Aizpurua, D., Cruz-Gonzalez, I., Ruiz-Nodar, J. M., Kim, J.-S., Freixa, X., Lopez-Minguez, J. R., De Backer, O., Ruiz-Salmeron, R., Dominguez, A., McInerney, A. Tags: Open access Arrhythmias and sudden death Source Type: research