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Total 262 results found since Jan 2013.

Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review
Conclusions AF is common in HCM and associated with high thromboembolic risk. LA dimension and age are independently associated with AF but the literature is insufficient to create robust clinical tools to predict AF or thromboembolism. Most data suggest that AF patients should be anticoagulated.
Source: Heart - February 19, 2014 Category: Cardiology Authors: Guttmann, O. P., Rahman, M. S., O'Mahony, C., Anastasakis, A., Elliott, P. M. Tags: Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Epidemiology Heart failure and cardiomyopathies Source Type: research

Stroke prevention by percutaneous closure of patent foramen ovale: a systematic review and meta-analysis
Conclusions Percutaneous closure of PFO in patients with cryptogenic stroke does not appear superior to medical therapy according to currently available randomised data. Furthermore, it is associated with an increased incidence of atrial fibrillation. However, there are signals pointing towards a potential benefit and more research should be strongly encouraged.
Source: Heart - February 10, 2014 Category: Cardiology Authors: Wolfrum, M., Froehlich, G. M., Knapp, G., Casaubon, L. K., DiNicolantonio, J. J., Lansky, A. J., Meier, P. Tags: Drugs: cardiovascular system, Epidemiology Aortic and vascular disease Source Type: research

Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients
Conclusions In this network meta-analysis, novel oral anticoagulants were the most promising treatments to reduce stroke, stroke or systemic embolism, and all-cause mortality in patients with AF.
Source: Heart - February 10, 2014 Category: Cardiology Authors: Dogliotti, A., Paolasso, E., Giugliano, R. P. Tags: Drugs: cardiovascular system, Epidemiology Arrhythmias and sudden death Source Type: research

Effects of antihypertensive treatment in patients over 65 years of age: a meta-analysis of randomised controlled studies
Conclusion Reducing BP to a level of 150/80 mmHg is associated with large benefit in stroke, cardiovascular and all-cause mortality as well as heart failure risk in elderly individuals. Different antihypertensive regimens with equal BP reduction have similar effects on cardiovascular outcomes. SBP rather than DBP reduction is significantly related to lower cardiovascular risk in this population.
Source: Heart - January 23, 2014 Category: Cardiology Authors: Briasoulis, A., Agarwal, V., Tousoulis, D., Stefanadis, C. Tags: Drugs: cardiovascular system, Hypertension, Epidemiology Cardiac risk factors and prevention Source Type: research

Progress: the ROPAC multinational registry advances our understanding of an important outcome in pregnant women with heart disease
When caring for women with structural heart disease (SHD), clinicians face an apparent paradox: most women with SHD are able to complete a pregnancy without complication; however, compared with the general population, maternal risk is increased and SHD remains a major source of maternal morbidity and mortality and poor fetal outcomes.1–4 Identifying those women with SHD who are at increased risk for meaningful complications during pregnancy is critical. During pregnancy, intravascular volume, stroke volume, heart rate and cardiac output increase, while systemic vascular resistance decreases. During pregnancy, women w...
Source: Heart - January 3, 2014 Category: Cardiology Authors: Krieger, E. V., Stout, K. K. Tags: Congenital heart disease, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Editorials Source Type: research

Ethnicity and prediction of cardiovascular disease: performance of QRISK2 and Framingham scores in a UK tri-ethnic prospective cohort study (SABRE--Southall And Brent REvisited)
Conclusions Neither score performed consistently well in all ethnic groups. Further validation of QRISK2 in other multi-ethnic datasets, and better methods for identifying high risk African Caribbeans and South Asian women, are required.
Source: Heart - December 6, 2013 Category: Cardiology Authors: Tillin, T., Hughes, A. D., Whincup, P., Mayet, J., Sattar, N., McKeigue, P. M., Chaturvedi, N., On behalf of the SABRE Study Group, Chaturvedi, Baker, Beauchamp, Coady, Collins, Forouhi, Gedroyc, Godsland, Hattersley, Heasman, Hughes, Key, Majeed, March, Tags: Open access, Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Source Type: research

Cardiovascular highlights from non-cardiology journals
This study included randomised trials of drugs to lower blood pressure that were compared with placebo or other drugs with at least 1000 patient years of follow-up in each treatment arm. The primary outcome was major CV events (the composite of stroke, myocardial infarction, heart failure or CV death), with secondary outcomes of each element of the composite outcome as well as all-cause mortality. These 26 trials included 152 290 patients, of which 30 295 had impaired renal function (estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2). Meta-analysis according to baseline kidney fu...
Source: Heart - December 6, 2013 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Preserved stroke volume late after tetralogy repair, despite severe right ventricular dilatation
To the Editor Right ventricular (RV) enlargement due to increased pulmonary regurgitation has been identified as a significant issue in patients after repair of tetralogy of Fallot. In a recent study, O'Meagher et al1 reported an interesting observation; exercise capacity and stroke volume are maintained with RV end-diastolic volume index (RVEDVi) above, as opposed to below, a commonly used cut-off (150 mL/m2 of RVEDVi) for pulmonary valve replacement (PVR) surgery. They go on to conclude that the optimal timing for PVR remains unclear.1 We agree with their conclusion because the evidence provided by currently availab...
Source: Heart - November 20, 2013 Category: Cardiology Authors: Masutani, S., Senzaki, H. Tags: PostScript Source Type: research

Global left ventricular longitudinal systolic strain as a major predictor of cardiovascular events in patients with atrial fibrillation
Conclusions GLS was a major parameter and stronger than LVEF and Sa in predicting adverse CV events and could offer an additional prognostic benefit over conventional clinical and echocardiographic systolic parameters in AF.
Source: Heart - October 6, 2013 Category: Cardiology Authors: Su, H.-M., Lin, T.-H., Hsu, P.-C., Lee, W.-H., Chu, C.-Y., Lee, C.-S., Voon, W.-C., Lai, W.-T., Sheu, S.-H. Tags: Drugs: cardiovascular system, Echocardiography, Hypertension, Clinical diagnostic tests, Epidemiology Cardiovascular imaging Source Type: research

The positive predictive value of ct-proAVP (copeptin) in patients with STEMI
Recently Reinstadler et al reported on a study in n=54 patients diagnosed with STEMI who underwent copeptin sampling 2 (1–3) days after the index event and Cardiac Magnetic Resonance (CMR) on the same day. A follow-up CMR study was done after 4 months in n=47 patients. The authors found a strong and significant correlation between day 2 copeptin and ejection fraction, end systolic volume, stroke volume and per cent infarct mass. Additionally, using optimised cutoffs, adverse remodelling could be excluded by the combination of copeptin with NT-proBNP.1 Copeptin is a stable glycopeptide comprising the C-terminal p...
Source: Heart - September 20, 2013 Category: Cardiology Authors: Mockel, M., Searle, J. Tags: Drugs: cardiovascular system, Hypertension, Interventional cardiology, Acute coronary syndromes, Clinical diagnostic tests Editorials Source Type: research

Cognitive outcomes after acute coronary syndrome: a population based comparison with transient ischaemic attack and minor stroke
Conclusions Risk of cognitive impairment after ACS is similar to minor stroke and higher than TIA with implications for clinical practice including consent and adherence with medication. Differences in cognitive domain performance suggest a greater role for degenerative brain pathology in ACS which may be linked to vascular risk profile and cardiac factors.
Source: Heart - September 20, 2013 Category: Cardiology Authors: Volonghi, I., Pendlebury, S. T., Welch, S. J. V., Mehta, Z., Rothwell, P. M. Tags: Acute coronary syndromes, Drugs: cardiovascular system, Hypertension, Epidemiology, Tobacco use Source Type: research

Patent foramen ovale closure and brain ischaemic lesions
To the Editor The recently published meta-analysis by Wolfrum et al assessed the ability of percutaneous closure of patent foramen ovale (PFO) to reduce the incidence of recurrent stroke based on three randomised controlled clinical trials (RCT). This analysis did not demonstrate a superiority of the closure of PFO compared with medical therapy after 2–4 years of follow-up in patients with cryptogenic embolism.1 The closure was associated with lower, albeit nonsignificant, incidence of nonfatal stroke. The relatively low incidence of nonfatal strokes in the medical arm (<1% per year), could have contributed t...
Source: Heart - September 20, 2013 Category: Cardiology Authors: Ammirati, E., Comi, G., Camici, P. G. Tags: PostScript Source Type: research

Almanac 2013: Novel non-coronary cardiac interventions
Recent innovations in interventional cardiology have dramatically expanded the therapeutic options for patients with cardiac conditions. Interventional cardiology is no longer limited to the treatment of coronary artery disease but allows also treatment of valvular disease, stroke prevention, hypertension, etc. One of the most important new treatment options is the percutaneous treatment for aortic valve stenosis (transcatheter aortic valve implantation), since aortic valve disease is a rather common problem in elderly patients, with many of them at high risk for surgery. Similarly, mitral regurgitation is often associated...
Source: Heart - August 15, 2013 Category: Cardiology Authors: Meier, P., Franzen, O., Lansky, A. J. Tags: Drugs: cardiovascular system, Hypertension, Interventional cardiology, Aortic valve disease, Mitral valve disease Almanac 2013 Source Type: research

Secondhand smoke exposure and intermittent claudication: a Scotland-wide study of 4231 non-smokers
Conclusions As with coronary heart disease and stroke, SHS exposure was independently associated with IC. Our findings add to the published evidence in support of protecting the general public from SHS exposure.
Source: Heart - August 15, 2013 Category: Cardiology Authors: Lu, L., Mackay, D. F., Pell, J. P. Tags: Health policy, Drugs: cardiovascular system, Epidemiology, Tobacco use Peripheral vascular disease Source Type: research