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Migraine pathophysiology: lessons from mouse models and human genetics
Publication date: January 2015 Source:The Lancet Neurology, Volume 14, Issue 1 Author(s): Michel D Ferrari , Roselin R Klever , Gisela M Terwindt , Cenk Ayata , Arn M J M van den Maagdenberg Summary Migraine is a common, disabling, and undertreated episodic brain disorder that is more common in women than in men. Unbiased genome-wide association studies have identified 13 migraine-associated variants pointing at genes that cluster in pathways for glutamatergic neurotransmission, synaptic function, pain sensing, metalloproteinases, and the vasculature. The individual pathogenetic contribution of each gene variant is diffi...
Source: The Lancet Neurology - December 9, 2014 Category: Neurology Source Type: research
Recruiting to inpatient-based rehabilitation trials: lessons learned
Recruitment to clinical trials is often challenging. A multi-center RCT recruiting stroke rehabilitation patients identified that the most successful strategies included using inclusive recruitment, ‘watchful waiting’, and structured engagement with the whole stroke multi-disciplinary team.
Source: Trials - March 4, 2015 Category: Journals (General) Authors: Sarah TysonNessa ThomasAndy VailPippa Tyrrell Source Type: research
Meditate And Live Longer
Before I practiced medicine at my Wellness Center, I was a sports physiology educator. So I know first-hand the value of a sound mind in a sound body.
In fact, my “whole-body, whole-mind” approach led me to study anti-aging in depth, which as you know has become my main areas of specialization. In fact, I was one of the first physicians in the country to be certified as an anti-aging specialist.
While advising a gymnastics team back in those early days, I often found myself dealing with the mental states of athletes.
And that’s when I really discovered the power of meditation. I taught many of these gymna...
Source: Al Sears, MD Natural Remedies - March 24, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Anti-Aging breathe breathing energy exercise meditate meditation toxins Source Type: news
Meet the Chinese Lumberjack Who Slept With an Alien
"If you can't find me," Meng Zhaoguo said over a cell phone whose signal faded from its isolation, "Just head to the last house on the logging commune lane. Or ask anyone who's around." Everyone knows the first Chinese person to allegedly be abducted by aliens.
With its surging economy, China is summiting once-unseen heights in world rankings: millions of English speakers, almost the most millionaires and actually the least frugal tourists. Yet despite being slightly larger in area than the United States with four times as many people, China trails far behind when it comes to visitors from outer space. To date, only one C...
Source: Science - The Huffington Post - April 7, 2015 Category: Science Source Type: news
The Impact of Policy, Environmental, and Educational Interventions: A Synthesis of the Evidence From Two Public Health Success Stories
Motor vehicle safety and tobacco control are among the greatest public health achievements of the 20th century, according to the Centers for Disease Control and Prevention. As the number of miles traveled in the United States multiplied 10 times from the 1920s to the 1990s, the annual motor vehicle crash death rate per vehicle mile traveled decreased by 90%. Similarly, tobacco-related deaths from heart disease, stroke, and cancer were rapidly mounting over the first two thirds of the 20th century. Then, in the last third of the century, tobacco consumption decreased by more than 50%, and rates of heart disease and stroke d...
Source: Health Education - March 31, 2015 Category: Health Management Authors: Gielen, A. C., Green, L. W. Tags: Articles Source Type: research
The Four Pillars of Longevity and Well-Being
by guest blogger Pam Peeke, MD, MPH, FACP, best-selling author and expert on health, fitness, and nutrition When I began my undergraduate years at the University of California-Berkeley, I chose cellular biology as my premed major. Enthused as I was with each course, I felt something was missing. Seeking an answer to my angst, I'd often take long, reflective walks around campus, through eucalyptus groves populated by cackling blue Steller's jays and verdant gardens punctuated by bright hibiscus and bougainvillea. And then it hit me: The answer was literally right under my nose. Gazing at the greenery around me, I realized h...
Source: Healthy Living - The Huffington Post - January 19, 2016 Category: Consumer Health News Source Type: news
SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study
Although cardiovascular (CV) mortality is the principal cause of death in individuals with type 2 diabetes (T2DM), reduction of plasma glucose concentration has little effect on CV disease (CVD) risk. Thus, novel strategies to reduce CVD risk in T2DM patients are needed. The recently published BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) study demonstrated that in T2DM patients with high CVD risk empagliflozin reduced the primary major adverse cardiac event end point (CV death, nonfatal myocardial infarction, nonfatal stroke) by 14%. This beneficial eff...
Source: Diabetes Care - April 20, 2016 Category: Endocrinology Authors: Abdul-Ghani, M.; Del Prato, S.; Chilton, R.; DeFronzo, R. A. Tags: Cardiovascular Disease and Diabetes Source Type: research
The Woman Who Lost Her Sense of 'Mine'
(Photo: Steven Taylor)
By Melissa Dahl
People get attached to their stuff. Two-year-olds, for instance, have very strong opinions about what's theirs ("MINE!"), and are suspicious about sharing, no matter what nonsense their adult caregivers spew about this caring thing. And although (most) people eventually learn to follow appropriate social norms, that relationship to stuff and things still matters throughout the life span, and even, in a way, beyond it -- when you're gone, after all, your loved ones will likely inherit your most prized possessions. If nothing else, at least your memory will live on through, say, a par...
Source: Healthy Living - The Huffington Post - July 22, 2016 Category: Consumer Health News Source Type: news
Advice For A Happy, Healthy Life From A Man Dedicated To Those Pursuits
Why do you what you do?
Can you trace the source of your professional motivation to a single event or person?
As CEO of the American Heart Association and American Stroke Association, I'm privileged to interact with many amazing leaders in cardiovascular medicine, technology, business and beyond. I'm always fascinated by the backstory of how each chose the path into a particular field.
When it comes to medical professionals, some simply love the science. Others are drawn by the desire to help people. And then there are those to whom it's personal.
Dr. Steven Houser fits all three categories.
After four years of playin...
Source: Healthy Living - The Huffington Post - November 22, 2016 Category: Consumer Health News Source Type: news
Thalamic pain alleviated by stellate ganglion block: A case report
Rationale: Thalamic pain is a distressing and treatment-resistant type of central post-stroke pain. Although stellate ganglion block is an established intervention used in pain management, its use in the treatment of thalamic pain has never been reported.
Patient concerns: A 66-year-old woman presented with a 3-year history of severe intermittent lancinating pain on the right side of the face and the right hand. The pain started from the ulnar side of the right forearm after a mild ischemic stroke in bilateral basal ganglia and left thalamus. Weeks later, the pain extended to the dorsum of the finger tips and the whole pa...
Source: Medicine - February 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Posterior reversible encephalopathy syndrome in a postpartum hemorrhagic woman without hypertension: A case report
Rationale: Posterior reversible encephalopathy syndrome (PRES), which diagnosis is based on clinical symptoms and radiological features, is a neurotoxic disease characterized by a set of clinical manifestations, such as seizure, headache, visual, and/or consciousness disturbance. It is the first case of PRES followed by postpartum hemorrhage (PPH) without underlying disease.
Patient concerns: A 37-year-old healthy woman had PPH after caesarean section. Six days after delivery, headache occurred suddenly, followed by episodes of clonus seizure.
Diagnoses: Brain computed tomography showed ischemic stroke. However, magnetic...
Source: Medicine - April 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
High-Risk Carotid Plaque: Lessons Learned from Histopathology
The pathophysiology and natural history of atherosclerotic carotid disease is predicated upon a more extensive knowledge of lesion progression gained in the studies conducted in the coronary arteries, and these will be reviewed. While the precise sequence of lesion progression leading to carotid plaque vulnerability and cerebrovascular events remain less well understood, specific early and more advanced progressive lesion morphologies associated with stroke risk have been characterized. Of late, there has been a conscious effort for stroke prevention in symptomatic and asymptomatic patients to move beyond luminal stenosis ...
Source: Seminars in Vascular Surgery - April 27, 2017 Category: Surgery Authors: Frank D. Kolodgie, Kazuyuki Yahagi, Maria E. Romero, Hugh H. Trout, Aloke V. Finn, Renu Virmani Source Type: research
rTMS treatments combined with speech training for a conduction aphasia patient: A case report with MRI study
We report the case of a 39-year-old woman who was initially diagnosed with conduction aphasia following a left hemisphere stroke.
Interventions: The rTMS location comprised the left Broca area, and a frequency of 5 Hz for 20 min/d for 10 days during a 2-week period was used. She had received speech rehabilitation training 1 month after stroke. Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging were used to investigate the functional and microstructural changes before and after rTMS treatment.
Outcomes: The results demonstrated that the Western Aphasia Battery scores significantly improved for l...
Source: Medicine - August 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
The Stent Is Not to Blame: Lessons Learned With a Simplified US Version of the Frozen Elephant Trunk
Conclusions With the advent of endovascular technology, there is a clinical shift toward increased use of FET to eliminate or facilitate the second surgical stage in treating patients with extensive aortic pathology. The addition of FET to the surgical armamentarium does not seem to pose additional risk (although larger studies are needed), but judicious use is advised nonetheless. A single-piece endoprosthesis for FET instead of a customized one should be considered.
Source: The Annals of Thoracic Surgery - October 18, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research
Case report: Central nervous system involvement of human graft versus host diseaseReport of 7 cases and a review of literature
We report 7 cases of CNS-GvHD among which two had histological-proven disease. We reviewed 32 additional cases of CNS GvHD published in literature since 1990. In this cohort, 34 patients were transplanted for hematologic malignancies, and 5 for non-malignant hematopoiesis disorders. Of these patients, 25 had a history of chronic GvHD and immunosuppressive treatment had been decreased or discontinued in 14 patients before neurological symptoms onset. Median neurological disorder onset was 385 days [7-7320]. Patients had stroke-like episodes (n = 7), lacunar syndromes (n = 3), multiple sclerosis-like presentations (n...
Source: Medicine - October 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
