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Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients.
Abstract We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were injected via their ventriculo-peritoneal shunts. Ten patients had Alzheimer's disease (AD), 6 had amyotrophic lateral sclerosis (ALS), 6 had progressive multiple sclerosis (MS-P), 6 had Parkinson's "Plus" (PD+), 1 had spinal cord injury, 1 had traumatic brain injury, and 1 had stroke. Median age wa...
Source: Molecular Biology Reports - July 19, 2019 Category: Molecular Biology Authors: Duma C, Kopyov O, Kopyov A, Berman M, Lander E, Elam M, Arata M, Weiland D, Cannell R, Caraway C, Berman S, Scord K, Stemler L, Chung K, Khoudari S, McRory R, Duma C, Farmer S, Bravo A, Yassa C, Sanathara A, Singh E, Rapaport B Tags: Mol Biol Rep Source Type: research

Acetaminophen Safe as First-Line Analgesic for Most Older Adults
FRIDAY, April 19, 2019 -- Despite a potential increased risk for stroke in patients with diabetes, acetaminophen is a safe first-line analgesic for most older adults living in nursing homes, according to a study published online March 26 in the...
Source: Drugs.com - Pharma News - April 19, 2019 Category: Pharmaceuticals Source Type: news

Acetaminophen Tied to Stroke Risk in Older Adults With Diabetes Acetaminophen Tied to Stroke Risk in Older Adults With Diabetes
Caution urged in interpreting findings, as acetaminophen is still considered safe to use in elderly patients.Medscape Medical News
Source: Medscape Diabetes Headlines - April 9, 2019 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Acetaminophen linked to stroke risk for people with diabetes
A widely used pain relief drug may raise the risk for stroke in people with diabetes, a new study says.
Source: Health News - UPI.com - April 3, 2019 Category: Consumer Health News Source Type: news

Acetaminophen may increase stroke risk for those with diabetes
(American Geriatrics Society) Surprisingly, we are only now coming to understand how acetaminophen works -- and recent research shows that we may need to develop a better understanding of the need for caution when using acetaminophen, especially when it comes to avoiding some of the risks associated with its use. A team of researchers decided to study the safety of acetaminophen in a nursing home setting. Their study was published in the Journal of the American Geriatrics Society.
Source: EurekAlert! - Social and Behavioral Science - April 2, 2019 Category: International Medicine & Public Health Source Type: news

N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis.
Authors: Will JS, Snyder CJ, Westerfield KL Abstract Exertional Heat Illness with associated ischemic hepatitis (IH) is a common occurrence among military trainees; however, few specific therapies exist if unresponsive to appropriate supportive measures. A 27-year-old basic combat trainee presented with altered mental status, renal insufficiency, rhabdomyolysis, and a core temp of 107.9 °F after collapsing during a run, leading to the diagnosis of heat stroke. While the patient's azotemia and creatinine kinase levels rapidly improved with aggressive intravenous hydration, transaminases continued to increase to nea...
Source: Military Medicine - March 1, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Should You Take Aspirin Every Day? Here ’s What the Science Says
Aspirin is best known as an over-the-counter painkiller. But acetylsalicylic acid, as it’s called chemically, has many other health benefits, as well as side effects, in the body that have only become clear in recent years. Here’s what the latest science says about the health benefits and side effects of aspirin, as well as which conditions it may treat and those it doesn’t appear to improve. (If you are taking aspirin for any reason other than for periodic pain relief, it’s best to consult with your doctor to confirm whether the benefits outweigh the risks in your particular case.) How aspirin affe...
Source: TIME: Health - November 8, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Drugs healthytime Source Type: news

ESO Launches Surveillance Form for Overdose
AUSTIN, Texas – ESO Solutions, Inc., the leading data and software company serving emergency medical services (EMS), hospitals and fire departments, today announced the launch of its Surveillance Form for Overdose. The new form will help standardize definitions and create a process that captures all essential data related to overdoses in a simple, easy-to-use format while eliminating duplicate entry of information. Additionally, the form is designed to highlight issues related to the well-being and safety of providers by identifying any injury-related events associated with a response.  “We feel the new Surveillan...
Source: JEMS: Journal of Emergency Medical Services News - March 6, 2018 Category: Emergency Medicine Authors: ESO Solutions, Inc. Tags: Documentation & Patient Care Reporting Industry News Source Type: news

Letter by Noubiap and Kamtchum-Tatuene Regarding Article, “PAIS 2 (Paracetamol Acetaminophen in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial” Letter to the Editor
Source: Stroke - June 26, 2017 Category: Neurology Authors: Jean Jacques Noubiap, Joseph Kamtchum-Tatuene Tags: Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Response by de Ridder et al to Letter Regarding Article, “PAIS 2 (Paracetamol Acetaminophen in Stroke 2) Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial” Letter to the Editor
Source: Stroke - June 26, 2017 Category: Neurology Authors: Inger R. de Ridder, Diederik W.J. Dippel, H. Bart van der Worp Tags: Pharmacology, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Letters to the Editor Source Type: research

PAIS 2 (Paracetamol Acetaminophen in Stroke 2) Clinical Sciences
Conclusions—Treatment with high-dose paracetamol seemed to be safe. The effect of high-dose paracetamol on functional outcome remains uncertain. Therefore, a large trial of early treatment with high-dose paracetamol is still needed.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR2365.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Inger R. de Ridder, Heleen M. den Hertog, H. Maarten A. van Gemert, A.H.C.M.L. (Tobien) Schreuder, Annemieke Ruitenberg, E. (Lisette) Maasland, Ritu Saxena, Jordie H. van Tuijl, Ben P.W. Jansen, Renske M. Van den Berg-Vos, Frederique Vermeij, Peter J. Kou Tags: Pharmacology, Meta Analysis, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Effect of paracetamol (acetaminophen) on body temperature in acute stroke: A meta-analysis
The objective of this study was to assess the efficacy of paracetamol (acetaminophen) on body temperature in acute stroke.
Source: The American Journal of Emergency Medicine - March 17, 2017 Category: Emergency Medicine Authors: Junjie Fan, Chensong Cheng, Hongsen Cheng, Ren Wang, Linhao Ma Source Type: research

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