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Low-dose 7,8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy Development
AbstractTemporal lobe epilepsy often manifests months or even years after an initial epileptogenic insult (e.g., stroke, trauma, status epilepticus) and, therefore, may be preventable. However, no such preventive treatment is currently available. Aim of this study was to test an antioxidant agent, 7,8-dihydroxyflavone (7,8-DHF), that is well tolerated and effective in preclinical models of many neurological disorders, as an anti-epileptogenic drug. However, 7,8-DHF also acts as a TrkB receptor agonist and, based on the literature, this effect may imply an anti- or a pro-epileptogenic effect. We found that low- (5  mg/kg),...
Source: Neurotherapeutics - September 30, 2022 Category: Neurology Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium ‐pilocarpine‐induced status epilepticus
ConclusionsGlycyrrhizin may exert neuroprotective effects via inhibiting HMGB1 and protect BBB permeability in lithium ‐pilocarpine‐induced rats with SE.
Source: Journal of Pharmacy and Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Ya ‐jun Li, Lin Wang, Bei Zhang, Fei Gao, Chun‐Mei Yang Tags: Research Paper Source Type: research

Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus
Publication date: Available online 1 November 2018Source: Neuroscience LettersAuthor(s): Marharyta Semenikhina, Ruslan Bogovyk, Mykhailo Fedoriuk, Oksana Nikolaienko, Lina T. AlKury, Alina Savotchenko, Oleg Krishtal, Elena IsaevaAbstractThe blood-brain barrier (BBB) is a unique structure that controls substances exchange between the systemic circulation and the brain. Disruption of its integrity contributes to the development and progression of a variety of brain disorders including stroke, epilepsy and neurodegenerative diseases. It was shown that intracerebral thrombin level substantially increases following status epile...
Source: Neuroscience Letters - November 2, 2018 Category: Neuroscience Source Type: research

The Role of Gastrodin on Hippocampal Neurons after N-Methyl-D-Aspartate Excitotoxicity and Experimental Temporal Lobe Seizures.
In conclusion, gastrodin failed to suppress in vivo and in vitro seizures in our study. Gastrodin showed no effect on hippocampal Schaffer collateral EPSP. These findings suggest that gastrodin does not interact with ionotropic glutamate receptors to inhibit NMDA receptor-facilitated seizures. However, gastrodin showed protective effects against NMDA toxicity on cultured hippocampal slices. Nevertheless, gastrodin is still a potential neuroprotective agent against NMDA excitotoxicity, with potential benefits for stroke and patients with epilepsy. PMID: 27188468 [PubMed - as supplied by publisher]
Source: The Chinese Journal of Physiology - May 20, 2016 Category: Physiology Tags: Chin J Physiol Source Type: research

Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
Abstract The discovery and validation of biomarkers in neurological and neurodegenerative diseases is an important challenge for early diagnosis of disease and for the development of therapeutics. Epilepsy is often a consequence of brain insults such as traumatic brain injury or stroke, but as yet no biomarker exists to predict the development of epilepsy in patients at risk. Given the complexity of epilepsy, it is unlikely that a single biomarker is sufficient for this purpose, but a combinatorial approach may be needed to overcome the challenge of individual variability and disease heterogeneity. The goal of the...
Source: Epilepsy and Behaviour - November 2, 2015 Category: Neurology Authors: Bröer S, Löscher W Tags: Epilepsy Behav Source Type: research