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Specialty: Drugs & Pharmacology
Drug: Insulin
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Total 70 results found since Jan 2013.
Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Drugs & Pharmacology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research
The efficacy and safety of Chinese herbal medicine as an add-on therapy for type 2 diabetes mellitus patients with carotid atherosclerosis: An updated meta-analysis of 27 randomized controlled trials
Conclusion: Based on this meta-analysis, we found that in the treatment of T2DM patients with CAS, combined with CHM may have more advantages than WM alone, which can further reduce CIMT and carotid plaque Crouse score, regulate glucose and lipid metabolism, improve insulin resistance and enhance islet β-cell function. Meanwhile, CHM is relatively safe. However, limited by the quality and heterogeneity of included studies, the efficacy and safety of CHM remain uncertain. More high-quality studies are still needed to provide more reliable evidence for the clinical application of CHM.Systematic Review Registration:https://w...
Source: Frontiers in Pharmacology - March 23, 2023 Category: Drugs & Pharmacology Source Type: research
Activation of the Akt/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke
Can J Physiol Pharmacol. 2022 Oct 31. doi: 10.1139/cjpp-2022-0341. Online ahead of print.ABSTRACTAutophagy has been implicated in stroke. Our previous study showed that the FoxO3 transcription factor promotes autophagy after transient cerebral ischemia/reperfusion (I/R). However, whether the Akt/FoxO3 signaling pathway plays a regulatory role in autophagy in cerebral I/R-induced oxidative stress injury is still unclear. The present study aims to investigate the effects of the Akt/FoxO3 signaling pathway on autophagy activation and neuronal injury in vitro and in vivo. By employing LY294002 or insulin to regulate the Akt/Fo...
Source: Canadian Journal of Physiology and Pharmacology - October 31, 2022 Category: Drugs & Pharmacology Authors: Aiqing Deng Limin Ma Qiuhong Ji Jiajun Xing Jianxin Qin Xueli Zhou Xin Wang Shouyan Wang Jianjun Wu Xia Chen Source Type: research
Crosstalk between neurological, cardiovascular, and lifestyle disorders: insulin and lipoproteins in the lead role
Pharmacol Rep. 2022 Sep 23. doi: 10.1007/s43440-022-00417-5. Online ahead of print.ABSTRACTInsulin resistance and impaired lipoprotein metabolism contribute to a plethora of metabolic and cardiovascular disorders. These alterations have been extensively linked with poor lifestyle choices, such as consumption of a high-fat diet, smoking, stress, and a redundant lifestyle. Moreover, these are also known to increase the co-morbidity of diseases like Type 2 diabetes mellitus and atherosclerosis. Under normal physiological conditions, insulin and lipoproteins exert a neuroprotective role in the central nervous system. However, ...
Source: Pharmacological Reports - September 23, 2022 Category: Drugs & Pharmacology Authors: Richa Tyagi Bhupesh Vaidya Shyam Sunder Sharma Source Type: research
The Potential Role of Naringin and Naringenin as Nutraceuticals against Metabolic Syndrome
Endocr Metab Immune Disord Drug Targets. 2022 Aug 27. doi: 10.2174/1871530322666220827141203. Online ahead of print.ABSTRACTMetabolic syndrome, an increasing problem in western society, is a cluster of conditions which affects cardiovascular health, lipid and glucose management, increasing the risk of heart diseases, stroke and diabetes. Bioactive flavonoids are a great resource of compounds with proved anti-inflammatory activities. Naringin, a natural flavanone found in citrus fruits, and its aglycone have demonstrated to ameliorate obesity, dyslipidemia, and insulin resistance in animal models. The principal mechanisms b...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 31, 2022 Category: Drugs & Pharmacology Authors: Luca Massaro Anna Raguzzini Paola Aiello D ébora Villaño Valencia Source Type: research
Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases
Neuropharmacology. 2021 Nov 8:108877. doi: 10.1016/j.neuropharm.2021.108877. Online ahead of print.ABSTRACTInsulin and leptin are classically regarded as peptide hormones that play key roles in metabolism. In actuality, they serve several functions in both the periphery and central nervous system (CNS). Likewise, insulin and leptin resistance can occur both peripherally and centrally. Metabolic disorders such as diabetes and obesity share several key features including insulin and leptin resistance. While the peripheral effects of these disorders are well-known (i.e. cardiovascular disease, hypertension, stroke, dyslipidem...
Source: Neuropharmacology - November 11, 2021 Category: Drugs & Pharmacology Authors: Jennifer M Erichsen Jim R Fadel Lawrence P Reagan Source Type: research
Research Progress on Catalpol as Treatment for Atherosclerosis
Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common diseases with high morbidity and mortality rates and must be addressed. Their most frequent complications, including myocardial infarction and stroke, are caused by spontaneous thrombotic occlusion and are the most frequent cause of death worldwide. Atherosclerosis (AS) is the most widespread underlying pathological change for the above diseases. Therefore, drugs that interfere with this pathophysiological process must be incorporated in the treatment. Chinese traditional and herbal drugs can effectively treat AS. With...
Source: Frontiers in Pharmacology - July 13, 2021 Category: Drugs & Pharmacology Source Type: research
Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury
Biomed Pharmacother. 2021 Feb 27;138:111441. doi: 10.1016/j.biopha.2021.111441. Online ahead of print.ABSTRACTMetabolic syndrome (MetS) is a complex, multifactorial disease which lead to an increased risk of cardiovascular disease, type 2 diabetes, and stroke. However, selective, and potent drugs for the treatment of MetS are still lacking. Previous studies have found that Akebia saponin D (ASD) has beneficial effects on metabolic diseases such as obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Therefore, our study was designed to determine the effect and mechanism of action of ASD against MetS in ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2021 Category: Drugs & Pharmacology Authors: Song Yang Ting Hu He Liu Ya-Li Lv Wen Zhang Han Li Lingling Xuan Li-Li Gong Li-Hong Liu Source Type: research
