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Drug: Fluoxetine

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Total 187 results found since Jan 2013.

The efficacy and safety of fluoxetine versus placebo for stroke recovery: a meta-analysis of randomized controlled trials
ConclusionFluoxetine improved FMMS and reduced anxiety and depression. More well-designed and large sample-size RCTs are required to further analyze the efficacy of fluoxetine in post-stroke recovery.
Source: International Journal of Clinical Pharmacy - April 20, 2023 Category: Drugs & Pharmacology Source Type: research

Treatments to post-stroke depression, which is more effective to HAMD improvement? A network meta-analysis
Discussion: The combination of antidepressants with adjuvant therapy may enhance the efficacy of antidepressants and achieve better results than antidepressant monotherapy in both Hamilton depression scale changes at the end of week 4 or 8 and 50% Hamilton depression scale improvement rate. Acupuncture combined with fluoxetine treatment was more effective in the treatment of post-stroke depression at week 4, while rTMS combined with paroxetine was more effective at week 8. Further research is needed to determine whether acupuncture combined with fluoxetine is better than rTMS combined with paroxetine for post-stroke depression at week 8.
Source: Frontiers in Pharmacology - December 19, 2022 Category: Drugs & Pharmacology Source Type: research

Fluoxetine or Venlafaxine for Early Post Stroke Depression
Conclusions: PSD in the early phase affects a substantial number of the stroke patients. Venlafaxine has got a better outcome and adverse event profile compared to fluoxetine in this group of patients. However, larger multicenter studies will provide more helpful data in this area.
Source: Neurology India - December 19, 2022 Category: Neurology Authors: Vivek K Nambiar J Parvathy Tania M Philip K Abhijith S Sreeni Naveen K Panicker Amrutha V Ajai TS Dhanya Source Type: research

In-hospital predictors of post-stroke depression for targeted initiation of Selective Serotonin Reuptake Inhibitors (SSRIs)
Although SSRIs are no longer widely prescribed for post-stroke motor recovery, fluoxetine demonstrated beneficial effects on post-stroke depression (PSD). Given the potential side effects of SSRIs, targeted in...
Source: BMC Psychiatry - November 19, 2022 Category: Psychiatry Authors: Julie Yi, Justin Lu, Annie Yang and Elisabeth Breese Marsh Tags: Research article Source Type: research

Pharmaceutical interventions for emotionalism after stroke
CONCLUSIONS: Antidepressants may reduce the frequency and severity of crying or laughing episodes when compared to placebo, based on very low-certainty evidence. Our conclusions must be qualified by several methodological deficiencies in the trials and interpreted with caution despite the effect being very large. The effect does not seem specific to one drug or class of drugs. More reliable data are required before appropriate conclusions can be made about the treatment of post-stroke emotionalism. Future trialists investigating the effect of antidepressants in people with emotionalism after stroke should consider developi...
Source: Cochrane Database of Systematic Reviews - November 17, 2022 Category: General Medicine Authors: Sabine Allida Allan House Maree L Hackett Source Type: research

Cognitive Impairment After Stroke and Treatment With Fluoxetine: A Planned Analysis of the AFFINITY Randomized Controlled Trial
Am J Geriatr Psychiatry. 2022 Aug 20:S1064-7481(22)00494-8. doi: 10.1016/j.jagp.2022.08.002. Online ahead of print.NO ABSTRACTPMID:36115731 | DOI:10.1016/j.jagp.2022.08.002
Source: The American Journal of Geriatric Psychiatry - September 17, 2022 Category: Psychiatry Authors: Osvaldo P Almeida Graeme J Hankey Andrew Ford Christopher Etherton-Beer Leon Flicker Maree L Hackett AFFINITY Trial Collaboration Source Type: research

Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders
CONCLUSIONS: TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.PMID:36089851 | DOI:10.1080/13880209.2022.2116460
Source: Pharmaceutical Biology - September 12, 2022 Category: Drugs & Pharmacology Authors: Xiaoping Zhang Zeng Li Chuanpu Shen Jinzhi He Longfei Wang Lei Di Bin Rui Ning Li Zhicheng Liu Source Type: research