Filtered By:
Drug: Pravastatin

This page shows you your search results in order of relevance. This is page number 3.

Order by Relevance | Date

Total 49 results found since Jan 2013.

Total cerebral blood flow and mortality in old age: A 12-year follow-up study
Conclusions: Low total CBF is linked with higher risk of all-cause, noncardiovascular, and cardiovascular mortality in older people independent of clinical cardiovascular status.
Source: Neurology - November 25, 2013 Category: Neurology Authors: Sabayan, B., van der Grond, J., Westendorp, R. G., Jukema, J. W., Ford, I., Buckley, B. M., Sattar, N., van Osch, M. J. P., van Buchem, M. A., de Craen, A. J. M. Tags: MRI, All Cerebrovascular disease/Stroke, Cohort studies ARTICLE Source Type: research

Extravascular Optical Coherence Tomography: Evaluation of Carotid Atherosclerosis and Pravastatin Therapy Basic Sciences
Conclusions— OCT imaging offers the potential for real-time, detailed vessel lumen evaluation, potentially improving surgical accuracy and outcomes during cerebrovascular neurosurgical procedures. Pravastatin significantly increases vessel lumen patency in the ApoE–/– mouse on HFD.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Wicks, R. T., Huang, Y., Zhang, K., Zhao, M., Tyler, B. M., Suk, I., Hwang, L., Ruzevick, J., Jallo, G., Brem, H., Pradilla, G., Kang, J. U. Tags: Imaging, Coronary imaging: angiography/ultrasound/Doppler/CC, Other diagnostic testing, Computerized tomography and Magnetic Resonance Imaging Basic Sciences Source Type: research

Comparative effectiveness of generic and brand-name statins on patient outcomes: a cohort study.
CONCLUSION: Compared with those initiating brand-name statins, patients initiating generic statins were more likely to adhere and had a lower rate of a composite clinical outcome. PRIMARY FUNDING SOURCE: Teva Pharmaceuticals. PMID: 25222387 [PubMed - in process]
Source: Annals of Internal Medicine - September 16, 2014 Category: Internal Medicine Authors: Gagne JJ, Choudhry NK, Kesselheim AS, Polinski JM, Hutchins D, Matlin OS, Brennan TA, Avorn J, Shrank WH Tags: Ann Intern Med Source Type: research

Assessment of Lipophilic vs. Hydrophilic Statin Therapy in Acute Myocardial Infarction.
Conclusions:On 2-year comparison of hydrophilic and lipophilic statins there was no significant difference in prevention of secondary cardiovascular outcome. PMID: 25392071 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 12, 2014 Category: Cardiology Authors: Izawa A, Kashima Y, Miura T, Ebisawa S, Kitabayashi H, Yamamoto H, Sakurai S, Kagoshima M, Tomita T, Miyashita Y, Koyama J, Ikeda U Tags: Circ J Source Type: research

Differential Effects of Strong and Regular Statins on the Clinical Outcome of Patients With Chronic Kidney Disease Following Coronary Stent Implantation.
Conclusions:In patients with mild-to-moderate CKD, only strong statins were associated with lower risk compared with no statin, but regular statins were not. It is possible that taking a strong statin from the early stage of CKD is useful for suppression of cardiovascular events. PMID: 25739954 [PubMed - as supplied by publisher]
Source: Circulation Journal - February 24, 2015 Category: Cardiology Authors: Ishii M, Hokimoto S, Akasaka T, Fujimoto K, Miyao Y, Kaikita K, Oshima S, Nakao K, Shimomura H, Tsunoda R, Hirose T, Kajiwara I, Matsumura T, Nakamura N, Yamamoto N, Koide S, Oka H, Morikami Y, Sakaino N, Matsui K, Ogawa H, on behalf of the Kumamoto Inter Tags: Circ J Source Type: research

10-Second heart rate variability and cognitive function in old age
Conclusions: Participants with lower 10-second HRV have worse performance in reaction time and processing speed and experience steeper decline in their processing speed, independent of medications, cardiovascular risk factors, and comorbidities.
Source: Neurology - March 21, 2016 Category: Neurology Authors: Mahinrad, S., Jukema, J. W., van Heemst, D., Macfarlane, P. W., Clark, E. N., de Craen, A. J. M., Sabayan, B. Tags: All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, All epidemiology ARTICLE Source Type: research

Personalized absolute benefit of statin treatment for primary or secondary prevention of vascular disease in individual elderly patients
ConclusionsWith a multivariable prediction model the absolute treatment effect of a statin on MACE for individual elderly patients with and without vascular disease can be quantified. Because of high ARRs, treating all patients is more beneficial than prediction-based treatment for secondary prevention of MACE. For primary prevention of MACE, the prediction model can be used to identify those patients who benefit meaningfully from statin therapy.
Source: Clinical Research in Cardiology - August 22, 2016 Category: Cardiology Source Type: research

High-intensity Statin Treatments in Clinically Stable Patients on Aspirin Monotherapy 12 Months After Drug-eluting Stent Implantation: A Randomized Study
Conclusions Among clinically stable DES-treated patients on aspirin monotherapy, high-intensity statin treatment significantly reduced late adverse events compared with low-intensity statin treatment. Clinical trial registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01557075.
Source: Revista Espanola de Cardiologia - July 15, 2017 Category: Cardiology Source Type: research

Influence of Prevalent and Incident Atrial Fibrillation on Post-Trial Major Events in ALLHAT.
CONCLUSION: Post-trial follow-up revealed continued deleterious AF/AFL effects. The amlodipine (ALLHAT) and pravastatin (ALLHAT-LLT) treatment groups showed lower all-cause and non-CVD mortality compared to the chlorthalidone and usual-care groups, respectively. PMID: 28987246 [PubMed - in process]
Source: Journal of the National Medical Association - October 11, 2017 Category: General Medicine Tags: J Natl Med Assoc Source Type: research

High-intensity Statin Treatments in Clinically Stable Patients on Aspirin Monotherapy 12 Months After Drug-eluting Stent Implantation: A Randomized Study
ConclusionsAmong clinically stable DES-treated patients on aspirin monotherapy, high-intensity statin treatment significantly reduced late adverse events compared with low-intensity statin treatment.Clinical trial registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01557075.ResumenIntroducción y objetivosLa vigente guía de práctica clínica para el tratamiento de la hipercolesterolemia recomienda mantener la terapia intensiva con estatinas de los pacientes tratados con implante de stent farmacoactivo (SFA). Sin embargo, el tratamiento intensivo con estatinas, una vez estabilizado el paciente, con fre...
Source: Revista Espanola de Cardiologia - July 5, 2018 Category: Cardiology Source Type: research

Differences in Statin Utilization and Lipid-Lowering by Race, Ethnicity, and HIV Status in a Real-World Cohort of Persons with Human Immunodeficiency Virus and Uninfected Persons
ConclusionsAmong PWH with statin indication(s), Blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin utilized for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

Differences in statin utilization and lipid lowering by race, ethnicity, and HIV status in a real-world cohort of persons with human immunodeficiency virus and uninfected persons
ConclusionsAmong PWH with statin indication(s), blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin used for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - January 25, 2019 Category: Cardiology Source Type: research

Hydrogen sulfide stabilizes atherosclerotic plaques in apolipoprotein E knockout mice
In conclusion, H2S exerts protective effects against atherogenesis at least partly by stabilizing atherosclerotic plaque.Graphical abstract
Source: Pharmacological Research - April 6, 2019 Category: Drugs & Pharmacology Source Type: research

Lowering Targeted Atherogenic Lipoprotein Cholesterol Goals for Patients at “Extreme” ASCVD Risk
AbstractPurpose of ReviewTo review randomized interventional clinical and imaging trials that support lower targeted atherogenic lipoprotein cholesterol goals in “extreme” and “very high” atherosclerotic cardiovascular disease (ASCVD) risk settings. Major atherosclerotic cardiovascular event (MACE) prevention among the highest risk patients with ASCVD requires aggressive management of global risks, including lowering of the fundamental atherogenic ap olipoprotein B-associated lipoprotein cholesterol particles [i.e., triglyceride-rich lipoprotein remnant cholesterol, low-density lipoprotein cholesterol (LDL-C), and ...
Source: Current Diabetes Reports - November 20, 2019 Category: Endocrinology Source Type: research