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Total 446 results found since Jan 2013.
Data on vildagliptin and vildagliptin plus metformin combination in type-2 diabetes mellitus management
Bioinformation. 2021 Mar 31;17(3):413-423. doi: 10.6026/97320630017413. eCollection 2021.ABSTRACTIt is of interest to evaluate the clinical effectiveness and safety of vildagliptin as monotherapy and combination therapy of vildagliptin and metformin for the management of type 2 diabetes mellitus (T2DM) patients in Indian settings. The study included patients with T2DM (aged >18 years) receiving vildagliptin monotherapy and vildagliptin in combination with metformin therapy of various strengths. Data related to demographics, risk factors, medical history, glycated hemoglobin (HbA1c) levels, and medical therapies were ret...
Source: Bioinformation - June 7, 2021 Category: Bioinformatics Authors: Sambit Das A K Gupta Biplab Bandyopadhyaya B Harish Darla Vivek Arya Mahesh Abhyankar Santosh Revankar Source Type: research
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526160214. Online ahead of print.ABSTRACTAMP-activated protein kinase (AMPK) is a serine/threonine kinase and a driving or deterrent factor in the development of neurodegenerative diseases and dementia. AMPK affects intracellular proteins like the mammalian target of rapamycin (mTOR). Peroxisome proliferator-activated receptor-γ coactivator 1-α (among others) contributes to a wide range of intracellular activities based on its downstream molecules such as energy balancing (ATP synthesis), extracellular inflammation, cell growth, and neuronal cell d...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Marjan Nikbakhtzadeh Fatemeh Shaerzadeh Ghorbangol Ashabi Source Type: research
Sex-disparities in risk factors and atherosclerosis cardiovascular disease in diabetic patients
Conclusion: Among diabetic people, compared to males, females had a higher comorbid burden but received less optimal treatment, which might partly explain their higher prevalence of composite ASCVD and CHD.PMID:33874831 | DOI:10.1080/00325481.2021.1917930
Source: Postgraduate Medicine - April 20, 2021 Category: Internal Medicine Authors: Yue Sun Dong Yan Lijuan Cui Guiping Li Yan Sun Zirui Hao Source Type: research
Effects of continuous use of metformin on cardiovascular outcomes in patients with type 2 diabetes after acute myocardial infarction: A protocol for systematic review and meta-analysis
Conclusions:
This study expects to provide credible and scientific evidence for the efficacy and safety of metformin on cardiovascular outcomes after AMI in patients with T2DM.
Registration number:
10.17605/OSF.IO/S3MBP.
Source: Medicine - April 16, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association
Circulation. 2021 Mar 29:CIR0000000000000961. doi: 10.1161/CIR.0000000000000961. Online ahead of print.ABSTRACTThis statement summarizes evidence that adverse pregnancy outcomes (APOs) such as hypertensive disorders of pregnancy, preterm delivery, gestational diabetes, small-for-gestational-age delivery, placental abruption, and pregnancy loss increase a woman's risk of developing cardiovascular disease (CVD) risk factors and of developing subsequent CVD (including fatal and nonfatal coronary heart disease, stroke, peripheral vascular disease, and heart failure). This statement highlights the importance of recognizing APOs...
Source: Circulation - March 29, 2021 Category: Cardiology Authors: Nisha I Parikh Juan M Gonzalez Cheryl A M Anderson Suzanne E Judd Kathryn M Rexrode Mark A Hlatky Erica P Gunderson Jennifer J Stuart Dhananjay Vaidya American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombos Source Type: research
