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Drug: Metformin

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Total 446 results found since Jan 2013.

The Effect of Metformin on Vitamin B12 Deficiency and Stroke
CONCLUSIONS: T2DM is a significant risk factor to the development of ischemic stroke. We found an association between metformin use and vitamin B12 deficiency and an association between vitamin B12 deficiency and stroke risk in patients with T2DM. Diabetic patients who are taking metformin should monitor their vitamin B12 level.PMID:36841981
Source: The Israel Medical Association Journal - February 26, 2023 Category: General Medicine Authors: Nizar Horrany Wadie Abu Dahoud Yara Moallem Taleb Hajouj Merna Zreik Arnon Blum Source Type: research

Metformin Directly Binds to MMP-9 to Improve Plaque Stability
J Cardiovasc Dev Dis. 2023 Jan 30;10(2):54. doi: 10.3390/jcdd10020054.ABSTRACTVulnerable atherosclerotic plaque rupture is the principal mechanism that accounts for myocardial infarction and stroke. High matrix metalloproteinase-9 (MMP-9) expression and activity have been proven to lead to plaque instability. Metformin, a first-line treatment for type 2 diabetes, is beneficial to plaque vulnerability. However, the mechanism underlying its anti-atherogenic effect remains unclear. Molecular docking and surface plasmon resonance experiments showed that metformin directly interacts with MMP-9, and incubated MMP-9 overexpressin...
Source: Atherosclerosis - February 24, 2023 Category: Cardiology Authors: Xianda Chen Shuaixing Wang Wenli Xu Mingming Zhao Youyi Zhang Han Xiao Source Type: research

The association between renal impairment and polypharmacy among older Palestinian patients: a multi-center cross-sectional study
CONCLUSION: This study demonstrates a relationship between polypharmacy and renal impairment. Some people with renal impairment receive drugs that those with kidney illness should avoid or use with caution. It is important to prescribe only necessary medication, choose non-nephrotoxic alternatives, and frequently monitor renal function.PMID:36797685 | PMC:PMC9936647 | DOI:10.1186/s12875-023-02005-9
Source: Primary Care - February 16, 2023 Category: Primary Care Authors: Shayma Naghnaghia Zaher Nazzal Layan Abu Alya Rowa' Al-Ramahi Zakaria Hamdan Esra'a Samara Source Type: research