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Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension
For hypertensive patients without a history of stroke or myocardial infarction (MI), the China Stroke Primary Prevention Trial (CSPPT) demonstrated that treatment with enalapril-folic acid reduced the risk of ...
Source: BMC Medicine - October 25, 2022 Category: Internal Medicine Authors: Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J. Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G. Liu, Jie Jiang and Zugui Zhang Tags: Research article Source Type: research

The effect of folic acid in patients with cardiovascular disease: A systematic review and meta-analysis
Conclusion: This meta-analysis suggested that folic acid supplementation significantly reduced the risk of stroke in patients with CVD.
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map.
Conclusion: Reduced salt intake, omega-3 LC-PUFA use, and folate supplementation could reduce risk for some cardiovascular outcomes in adults. Combined calcium plus vitamin D might increase risk for stroke. Primary Funding Source: None. PMID: 31284304 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 8, 2019 Category: Internal Medicine Authors: Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, Vaughan L, Okunrintemi V, Riaz IB, Khan MS, Kaluski E, Murad MH, Blaha MJ, Guallar E, Michos ED Tags: Ann Intern Med Source Type: research

Review: Folic acid may reduce risk for CVD and stroke, and B-vitamin complex may reduce risk for stroke.
PMID: 30326088 [PubMed - in process]
Source: Annals of Internal Medicine - October 16, 2018 Category: Internal Medicine Authors: Aung K, Htay T Tags: Ann Intern Med Source Type: research

Time to Think About Nutrient Needs in Chronic Disease
There is renewed interest in health benefits of folic acid supplementation since the China Stroke Prevention Primary Prevention Trial (CSPPT) showed the potential benefits of folic acid in preventing stroke in Chinese adults with hypertension. It has long been known that folic acid prevents neural tube defects, which are among the most severe and debilitating congenital birth defects worldwide. The CSPPT was terminated early when 800 µg of folic acid in combination with 10 mg of enalapril significantly reduced primary stroke incidence compared with the enalapril alone treatment arm. This finding was unexpected as other st...
Source: JAMA Internal Medicine - August 22, 2016 Category: Internal Medicine Source Type: research

Effects of Folate on Chronic Kidney Disease Progression
This secondary analysis of China Stroke Primary Prevention Trial data compares the effects of folic acid and enalapril vs enalapril alone on progression of CKD.
Source: JAMA Internal Medicine - August 22, 2016 Category: Internal Medicine Source Type: research

In Chinese adults with hypertension, adding folic acid to enalapril reduced incident stroke.
PMID: 26192588 [PubMed - in process]
Source: Annals of Internal Medicine - July 21, 2015 Category: Internal Medicine Authors: Barer D Tags: Ann Intern Med Source Type: research

Is folic acid supplementation definitely beneficial to stroke prevention?: Comment on: Efficacy of folic acid supplementation in cardiovascular disease prevention: An updated meta-analysis of randomized controlled trials.
PMID: 23541460 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - March 28, 2013 Category: Internal Medicine Authors: Zhou C, Zhu L, Wu J, Fang S Tags: Eur J Intern Med Source Type: research