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Total 71 results found since Jan 2013.

Risk of Stroke Among Older Medicare Antidepressant Users With Traumatic Brain Injury
Conclusion: Findings from this study will aid prescribers in choosing appropriate antidepressants to treat depression in older adults with TBI.
Source: The Journal of Head Trauma Rehabilitation - January 1, 2017 Category: Neurology Tags: Focus on Clinical Research and Practice Source Type: research

Prevention of Poststroke Mortality Using Problem-Solving Therapy or Escitalopram.
CONCLUSION: To the authors' knowledge, this is the first time a psychological antidepressant treatment administered for 1 year has been associated with increased survival among patients who have suffered a stroke. PMID: 28029510 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - December 30, 2016 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Efficacy of early administration of escitalopram on depressive and emotional symptoms and neurological dysfunction after stroke: a multicentre, double-blind, randomised, placebo-controlled study
Publication date: January 2017 Source:The Lancet Psychiatry, Volume 4, Issue 1 Author(s): Jong S Kim, Eun-Jae Lee, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon Background Mood and emotional disturbances are common in patients with stroke, and adversely affect the clinical outcome. We aimed to evaluate the efficacy of early administration of escitalopram to reduce moderate or severe depressive symptoms and improve emotion...
Source: The Lancet Psychiatry - December 21, 2016 Category: Psychiatry Source Type: research

Efficacy observation on Governor Vessel-regulating and brain-unblocking acupuncture for post-stroke depression
Conclusion The Governor Vessel-regulating and brain-unblocking acupuncture is safe and effective for post-stroke depression and can obtain similar efficacy as Escitalopram Oxalate tablet. In addition, it can fast alleviate core symptoms of depression and improve the activities of daily living (ADL) and has fewer adverse reactions.
Source: Journal of Acupuncture and Tuina Science - May 31, 2016 Category: Complementary Medicine Source Type: research

Why The Science Behind Anti-Depressants May Be Completely 'Backwards'
Anti-depressants are the most commonly-prescribed medication in the U.S., with one in 10 Americans currently taking pills like Zoloft and Lexapro to treat depression. But these pharmaceuticals are only fully effective roughly 30 percent of the time, and often come with troublesome side effects. In a controversial new paper published in the journal Neuroscience & Biobehavioral Reviews, psychologist Paul Andrews of McMaster University in Ontario argues that this failure of medication may be based in a misunderstanding of the underlying chemistry related to depression. Andrews surveyed 50 years' worth of research supporti...
Source: Science - The Huffington Post - February 28, 2015 Category: Science Source Type: news

The Science Behind Anti-Depressants May Be Completely 'Backwards'
Anti-depressants are the most commonly-prescribed medication in the U.S., with one in 10 Americans currently taking pills like Zoloft and Lexapro to treat depression. But these pharmaceuticals are only effective less than 30 percent of the time, and often come with troublesome side effects. In a controversial new paper published in the journal Neuroscience & Biobehavioral Reviews, psychologist Paul Andrews of McMaster University in Ontario argues that this failure of medication may be based in a misunderstanding of the underlying chemistry related to depression. Andrews surveyed 50 years' worth of research supporting t...
Source: Healthy Living - The Huffington Post - February 28, 2015 Category: Consumer Health News Source Type: news

The Role of the Two-Pore Domain Potassium Channel TREK-1 in the Therapeutic Effects of Escitalopram in a Rat Model of Poststroke Depression.
CONCLUSION: TREK-1 plays an important role in the therapeutic effects of the SSRI escitalopram in PSD model, making TREK-1 an attractive candidate molecule for further understanding the pathophysiology and treatment of PSD. PMID: 25675906 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Lin DH, Zhang XR, Ye DQ, Xi GJ, Hui JJ, Liu SS, Li LJ, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research

Prevention of poststroke apathy using escitalopram or problem-solving therapy.
CONCLUSION: Escitalopram or PST was significantly more effective in preventing new onset of apathy following stroke compared with placebo. PMID: 23930743 [PubMed - in process]
Source: Am J Geriatr Psychia... - August 13, 2013 Category: Geriatrics Authors: Mikami K, Jorge RE, Moser DJ, Arndt S, Jang M, Solodkin A, Small SL, Fonzetti P, Hegel MT, Robinson RG Tags: Am J Geriatr Psychiatry Source Type: research

Table of Contents
Abstract Study of antidepressants finds modest effect on QT prolongation Reckitt blocked by FDA on buprenorphine, faces FTC inquiry SSRIs and tramadol: Possible link to serotonin syndrome Orexin receptor antagonist effective for insomnia Antipsychotics' receptor profiles linked to stroke risk FDA offers new guidance on developing drugs for Alzheimer's disease Common genetic variation and antidepressant efficacy Antipsychotics and weight change Pharmacogenetic study looks at cocaine abuse Polymorphism predicts escitalopram dose for depression D‐cycloserine impact on fear examined SSRI drugs and ischemic heart disease and ...
Source: The Brown University Psychopharmacology Update - April 9, 2013 Category: Psychiatry Source Type: research