• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Randomized controlled trial validating the use of perispinal etanercept to reduce post-stroke disability has wide-ranging implications.
Authors: Clark IA Abstract SummaryDeveloping effective drug treatments for neurodegenerative disorders has always been hamstrung by the accepted inability of large molecules (roughly those with a molecular weight greater than 600 Daltons) to cross the blood-brain barrier (BBB) in therapeutic quantities when administered systemically. The dogma has been that a simple, non-invasive way to accomplish this goal is not possible with many agents, including biologicals, because they are too large. Various novel technologies to breach the BBB have been attempted, but with little success. A randomised double-blind, placebo-con...
Source: Expert Review of Neurotherapeutics - February 8, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Reversible Cerebral Vasoconstriction Syndrome after Administering Etanercept during Puerperium
Our objective is to clarify relationship between reversible cerebral vasoconstriction syndrome and administrating etanercept during puerperium. Several lines of evidence have suggested tumor necrosis factor (TNF) as a mediator of vascular dysfunction associated with estrogen deficiency. A 32-year-old woman resumed etanercept (25 mg/week), a TNF inhibitor, which had been discontinued during pregnancy, because of the deterioration of rheumatoid arthritis. She was admitted to our hospital with upper right quadrant blindness and mild right hemiparesis accompanied by pulsating left occipital pain, which had appeared 4 hours aft...
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Daisuke Hara, Saki Nukui, Takahiro Shimizu, Hisanao Akiyama, Yasuhiro Hasegawa Tags: Case Report Source Type: research

Practice advisory: Etanercept for poststroke disability: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Conclusions: For patients with poststroke disability, the evidence is insufficient to support or refute a benefit of etanercept for the treatment of poststroke disability. Recommendations: Clinicians should counsel patients considering etanercept for treatment of poststroke disability that the evidence is insufficient to determine the treatment's effectiveness and that it may be associated with adverse outcomes and high cost (Level U).
Source: Neurology - June 5, 2016 Category: Neurology Authors: Gronseth, G. S., Messe, S. R. Tags: All Cerebrovascular disease/Stroke, All Rehabilitation SPECIAL ARTICLE Source Type: research

Therapeutically Targeting Tumor Necrosis Factor-{alpha}/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage Basic Sciences
Conclusions— Vascular smooth muscle cell TNFα and sphingosine-1-phosphate signaling significantly enhance cerebral artery tone in SAH; anti-TNFα and anti–sphingosine-1-phosphate treatment may significantly improve clinical outcome.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Yagi, K., Lidington, D., Wan, H., Fares, J. C., Meissner, A., Sumiyoshi, M., Ai, J., Foltz, W. D., Nedospasov, S. A., Offermanns, S., Nagahiro, S., Macdonald, R. L., Bolz, S.-S. Tags: Animal models of human disease, Acute Cerebral Hemorrhage, Brain Circulation and Metabolism, Other Stroke Treatment - Medical, Other Vascular biology Basic Sciences Source Type: research

Chronic Elevation of Tumor Necrosis Factor-{alpha} Mediates the Impairment of Leptomeningeal Arteriogenesis in db/db Mice Basic Sciences
Conclusions— These results indicate that leptomeningeal arteriogenesis is impaired in db/db mice and that suppression of the tumor necrosis factor-α response to hypoperfusion is the major contributing factor.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Yukami, T., Yagita, Y., Sugiyama, Y., Oyama, N., Watanabe, A., Sasaki, T., Sakaguchi, M., Mochizuki, H., Kitagawa, K. Tags: Cerebrovascular disease/stroke, Type 2 diabetes, Other Vascular biology Basic Sciences Source Type: research

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia
Conclusions: Our data suggest that XPro1595 and etanercept improve functional outcome after focal cerebral ischemia by altering the peripheral immune response, changing blood and spleen cell populations and decreasing granulocyte infiltration into the brain. Blocking solTNF, using XPro1595, was just as efficient as blocking both solTNF and tmTNF using etanercept. Our findings may have implications for future treatments with anti-TNF drugs in TNF-dependent diseases.
Source: Journal of Neuroinflammation - December 12, 2014 Category: Neurology Authors: Bettina ClausenMatilda DegnNellie MartinYvonne CouchLeena KarimiMaria OrmhøjMaria-Louise MortensenHanne GredalChris GardinerIan SargentDavid SzymkowskiGéraldine PetitTomas DeierborgBente FinsenDaniel AnthonyKate Lambertsen Source Type: research

Authors’ Reply to Whitlock: Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence
Source: CNS Drugs - November 6, 2014 Category: Neurology Source Type: research

Comment on: “Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence”
Source: CNS Drugs - November 6, 2014 Category: Neurology Source Type: research