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Drug: Colcrys

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Total 87 results found since Jan 2013.

Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week
J Am Coll Cardiol. 2023 Aug 15;82(7):648-660. doi: 10.1016/j.jacc.2023.05.055.ABSTRACTAmong statin-treated patients, inflammation assessed by means of high-sensitivity C-reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all-cause mortality than low-density-lipoprotein cholesterol (LDL-C). Several therapies that target residual inflammatory risk significantly reduce vascular event rates. For coronary artery disease patients already taking guideline-directed medical care, including statins, low-dose colchicine (0.5 mg/d orally) has been shown to safely lower major adverse cardiovascular even...
Source: Atherosclerosis - August 9, 2023 Category: Cardiology Authors: Kyle Nelson Valentin Fuster Paul M Ridker Source Type: research

Anti-inflammatory therapies were associated with reduced risk of myocardial infarction in patients with established cardiovascular disease or high cardiovascular risks: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Anti-inflammatory therapies, especially those targeting the central IL-6 signaling pathway, may serve as promising treating strategies to ameliorate the risk of MI. IL-1 inhibitor and colchicine were associated with decreased risks of heart failure and stroke, respectively. MI risk reduction by anti-inflammatory therapies seemed to be more prominent in older patients with long follow-up duration.PMID:37527612 | DOI:10.1016/j.atherosclerosis.2023.06.972
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: Zonglin Li Chu Lin Xiaoling Cai Suiyuan Hu Fang Lv Wenjia Yang Xingyun Zhu Linong Ji Source Type: research

A meta-analysis evaluating efficacy and safety of colchicine for prevention of major cardiovascular events in patients with coronary artery disease
ConclusionsColchicine is an effective, relatively safe drug that could be considered for the treatment of CAD. However, we need to pay attention to the increasing occurrence of non-cardiovascular mortality and infection especially pneumonia possibly caused by colchicine.Graphical abstractEfficacy and safety of colchicine for patients with CAD.CAD coronary artery disease;RCTs randomized controlled trials;OR odds ratio;MACEs major adverse cardiovascular events;ACS acute coronary syndrome;NNT number needed to treat;NNH number needed to harm
Source: Clinical Research in Cardiology - July 28, 2023 Category: Cardiology Source Type: research

Insights into the Role of Inflammation in the Management of Atherosclerosis
J Inflamm Res. 2023 May 24;16:2223-2239. doi: 10.2147/JIR.S276982. eCollection 2023.ABSTRACTAtherosclerosis is the biological basis of ischemic heart disease and ischemic stroke, the leading causes of death in the world. After decades of studies, the understanding of atherosclerosis has evolved dramatically, and inflammation has been recognized as one of the most relevant pillars in all phases of atherosclerotic disease. Nevertheless, only recently, the trial CANTOS, and subsequent outcome studies with colchicine, finally provided proof-of-concept evidence that anti-inflammatory therapies were able to reduce cardiovascular...
Source: Atherosclerosis - May 30, 2023 Category: Cardiology Authors: Viviane Zorzanelli Rocha Fabiana Hanna Rached Marcio Hiroshi Miname Source Type: research

Is Colchicine Involved in Managing Stroke?
Curr Vasc Pharmacol. 2023 May 19. doi: 10.2174/1570161121666230519143716. Online ahead of print.NO ABSTRACTPMID:37211843 | DOI:10.2174/1570161121666230519143716
Source: Current Vascular Pharmacology - May 22, 2023 Category: Drugs & Pharmacology Authors: Antonio Siniscalchi Piergiorgio Lochner Giovambattista De Sarro Luca Gallelli Source Type: research

Lipoprotein (a), Inflammation, and Atherosclerosis
J Clin Med. 2023 Mar 27;12(7):2529. doi: 10.3390/jcm12072529.ABSTRACTGrowing evidence has shown that high levels of lipoprotein (a) (Lp(a)) and chronic inflammation may be responsible for the residual risk of cardiovascular events in patients managed with an optimal evidence-based approach. Clinical studies have demonstrated a correlation between higher Lp(a) levels and several atherosclerotic diseases including ischemic heart disease, stroke, and degenerative calcific aortic stenosis. The threshold value of Lp(a) serum concentrations associated with a significantly increased cardiovascular risk is >125 nmol/L (50 mg/dL...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Stefania Angela Di Fusco Aldo Pietro Maggioni Pietro Scicchitano Marco Zuin Emilia D'Elia Furio Colivicchi Source Type: research

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial
Conclusions In this small, open-label, randomised trial of non-critically ill hospitalised patients with COVID-19, the combination of colchicine and rosuvastatin in addition to standard of care did not appear to reduce the risk of progression of COVID-19 disease or thromboembolic events, although the trial was underpowered due to a lower-than-expected event rate. The trial leveraged the power of electronic medical records for efficiency and improved follow-up and demonstrates the utility of incorporating electronic medical records into future trials. Trial registration NCT04472611.
Source: BMJ Open - February 24, 2023 Category: General Medicine Authors: Shah, T., McCarthy, M., Nasir, I., Archer, H., Ragheb, E., Kluger, J., Kashyap, N., Paredes, C., Patel, P., Lu, J., Kandel, P., Song, C., Khan, M., Huang, H., Ul Haq, F., Ahmad, R., Howes, C., Cambi, B., Lancaster, G., Cleman, M., Dela Cruz, C., Parise, H Tags: Open access, Infectious diseases, COVID-19 Source Type: research

Colchicine in Athero-Thrombosis: Molecular Mechanisms and Clinical Evidence
Int J Mol Sci. 2023 Jan 27;24(3):2483. doi: 10.3390/ijms24032483.ABSTRACTSeveral lines of evidence have clearly indicated that inflammation plays a pivotal role in the development of atherosclerosis and of its thrombotic complications such as acute coronary syndromes or ischemic stroke. Thus, it has been postulated that the use of anti-inflammatory agents might be extremely useful to improve cardiovascular outcome. Recently, increasing attention has been reserved to one of the oldest plant-derived drugs still in use in clinical practice, colchicine that has been used as drug to treat inflammatory diseases such gout or Medi...
Source: Atherosclerosis - February 11, 2023 Category: Cardiology Authors: Giovanni Cimmino Francesco S Loffredo Gennaro De Rosa Plinio Cirillo Source Type: research

Acute stroke in familial Mediterranean fever: An analysis of 23 new cases and systematic review of the literature
DiscussionThe acute stroke phenotype in FMF cases is herein described for the first time. Several clinicoradiological features such as thrombotic lacunar infarcts located in the central mesencephalon seem so typical that we recommend searching for FMF mutations in geographic regions where FMF is common.
Source: International Journal of Rheumatic Diseases - February 7, 2023 Category: Rheumatology Authors: Mehmet Akif Topcuoglu, Cansu Ayvacioglu ‐Cagan, Ethem Murat Arsava, Pınar Acar‐Ozen, Umut Kalyoncu, Rahsan Gocmen, Tayfun Hilmi Akbaba, Banu Balcı‐Peynircioğlu, Meryem Aslı Tuncer Tags: ORIGINAL ARTICLE Source Type: research

The potential of colchicine for lowering the risk of cardiovascular events in type 1 diabetes
Eur Heart J Cardiovasc Pharmacother. 2023 Jan 13:pvad005. doi: 10.1093/ehjcvp/pvad005. Online ahead of print.ABSTRACTIn type 1 diabetes, average life expectancy is reduced by more than 10 years as compared with outside of diabetes. Residual cardiovascular risk defines high cardiovascular event rate despite modern, guideline-recommended standard of care of established risk factors like hypertension, dyslipidaemia, and glycaemic control, and it adds importantly to these lost years of life in type 1 diabetes due to atherosclerotic cardiovascular disease like myocardial infarction and ischaemic stroke. With growing understandi...
Source: Atherosclerosis - January 13, 2023 Category: Cardiology Authors: Nicklas J ärvelä Johansen Filip Krag Knop Source Type: research