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Drug: Colcrys

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Total 87 results found since Jan 2013.

Colchicine in post-operative Atrial Fibrillation: a review.
Abstract Post-operative atrial fibrillation (POAF) is a frequent entity increasing hospitalization duration, stroke and mortality. In the recent years, a few studies have sought to investigate the potential effect of colchicine in POAF prevention after cardiac surgery or catheter pulmonary vein isolation for AF. In the present review article, we intend to provide a synopsis of clinical practice guidelines, summarize and critically approach current evidence for or against colchicine as a means of POAF prevention. PMID: 29336253 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - January 14, 2018 Category: Drugs & Pharmacology Authors: Vrachatis DA, Kossyvakis C, Angelidis C, Panagopoulou V, Sarri EK, Giotaki S, Siasos G, Vavuranakis M, Deftereos SG Tags: Curr Pharm Des Source Type: research

Outcomes of long term treatments of type I hereditary angioedema in a Turkish family
Conclusion: Patients with C1-INH hereditary angioedema may be misdiagnosed as having familial Mediterranean fever in regions where the disorder is endemic. Medical history, suspicion of hereditary angioedema and laboratory evaluations of patients and their family members lead the correct diagnoses of hereditary angioedema. Danazol and C1 replacement treatments provide significant reduction in hereditary angioedema attacks.
Source: Anais Brasileiros de Dermatologia - November 17, 2017 Category: Dermatology Source Type: research

Not as Simple as Canker Sores
BY ​NANA P. MATSUMOTO, & DEREK MEEKS, DO​​A 16-year-old boy presented to a rural ED with a swollen jaw, painful blisters in the mouth, and earache for the past day. One week before, he had a fever with chills, sore throat, and dry coughs. He was not taking any medications, and his immunizations were up-to-date. He had a mild learning disorder but no significant past medical or surgical history.​An apthous ulcer, the most common and one of the earliest signs of Behçet's disease.The patient's vital signs were within normal limits, and his physical examination revealed anterior cervical lymphadenopathy, sinus con...
Source: The Case Files - October 11, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Effects of colchicine on risk of cardiovascular events and mortality among patients with gout: a cohort study using electronic medical records linked with Medicare claims
Conclusions Colchicine use was associated with a reduced risk of a CV event among patients with gout.
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Solomon, D. H., Liu, C.-C., Kuo, I.-H., Zak, A., Kim, S. C. Tags: Genetics, Degenerative joint disease, Musculoskeletal syndromes, Epidemiology Clinical and epidemiological research Source Type: research

Management of postoperative atrial fibrillation after cardiac surgery
This article will review the available evidence on the prevention and treatment of atrial fibrillation after cardiac surgery. Using this knowledge, we propose a conceptual framework on the management of patients with POAF during various phases after cardiac surgery. Recent findings: Perioperative β-blockade is the cornerstone in preventing POAF after cardiac surgery. Results from randomized trials do not support routine use of colchicine or corticosteroids to prevent POAF. There is no study examining the impact of rate versus rhythm control on ‘hard’ clinical outcomes such as mortality or stroke in the cardiac surgic...
Source: Current Opinion in Cardiology - February 5, 2016 Category: Cardiology Tags: VALVULAR HEART DISEASE: Edited by Subodh Verma Source Type: research

Colchicine for prevention of cardiovascular events.
CONCLUSIONS: There is much uncertainty surrounding the benefits and harms of colchicine treatment. Colchicine may have substantial benefits in reducing myocardial infarction in selected high-risk populations but uncertainty about the size of the effect on survival and other cardiovascular outcomes is high, especially in the general population from which most of the studies in our review were drawn. Colchicine is associated with gastrointestinal side effects based on low-quality evidence. More evidence from large-scale randomised trials is needed. PMID: 26816301 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 27, 2016 Category: Journals (General) Authors: Hemkens LG, Ewald H, Gloy VL, Arpagaus A, Olu KK, Nidorf M, Glinz D, Nordmann AJ, Briel M Tags: Cochrane Database Syst Rev Source Type: research

Neuroprotective Mechanisms Mediated by CDK5 Inhibition.
This article discusses current evidence for the involvement of CDK5 deregulation in neurodegenerative disorders and neurodegeneration associated with stroke through various mechanisms. These include upregulation of cyclin D1 and overactivation of CDK5 mediated neuronal cell death pathways, aberrant hyperphosphorylation of human tau proteins and/or neurofilament proteins, formation of neurofibrillary lesions, excitotoxicity, cytoskeletal disruption, motor neuron death (due to abnormally high levels of CDK5/p25) and colchicine-induced apoptosis in cerebellar granule neurons. A better understanding of the role of CDK5 inhibit...
Source: Current Pharmaceutical Design - November 24, 2015 Category: Drugs & Pharmacology Authors: Mushtaq G, Greig NH, Anwar F, Al-Abbasi FA, Zamzami MA, Al-Talhi HA, Kamal MA Tags: Curr Pharm Des Source Type: research

Gout: Sleep apnea may raise your risk
Gout is the most common type of inflammatory arthritis and affects more than 8 million adults. Men are at a higher risk than women. And according to a new study, your risk for gout also climbs if you suffer from sleep apnea, a condition where your breathing repeatedly pauses while you sleep. What exactly is gout? Gout is triggered by the crystallization of uric acid within the joints. It happens like this: Your body produces uric acid from breaking down purines, a natural waste product of living cells. Normally, uric acid is dissolved in your blood and passes through your kidneys into your urine. However, sometimes your bo...
Source: New Harvard Health Information - November 17, 2015 Category: Consumer Health News Authors: Matthew Solan Tags: Arthritis Health Sleep gout sleep apnea Source Type: news

Colchicine in cardiac disease: a systematic review and meta-analysis of randomized controlled trials
Background: Colchicine has unique anti-inflammatory properties that may be beneficial in various cardiovascular conditions. This systematic review and meta-analysis of randomized controlled trials (RCTs) examines this issue. Methods: We searched MEDLINE, EMBASE, and the Cochrane Database from inception to June 2014 for RCTs using colchicine in adult patients with cardiac diseases. Results were pooled using random effects. Results: 15 RCTs (n = 3431 patients, median treatment 3 and follow-up 15 months) were included. All but 2 used colchicine 1 mg/day. In 5 trials, n = 1301) at risk for cardiovascular disease (cor...
Source: BMC Cardiovascular Disorders - August 29, 2015 Category: Cardiology Authors: Subodh VermaJohn EikelboomStefan NidorfMohammed Al-OmranNandini GuptaHwee TeohJan Friedrich Source Type: research

Is Intracranial Arterial Involvement A Subgroup of Neuro-Behcet Syndrome? (P5.035)
Conclusion:Neurological involvement in BS patients is generally due to venous inflammation. Intracranial arterial involvement in NBS is rare, but it should be kept in mind that it can occur during the course of the disease independent of other stroke risk factors.Disclosure: Dr. Zeydan has nothing to disclose. Dr. Uygunoglu has received personal compensation for activities with Merck Serono, Biogen Idec, Novartis and Allergan Inc. as an attendee at congresses or symposia. Dr. Tutuncu has nothing to disclose. Dr. Yalcinkaya has nothing to disclose. Dr. Altintas has received personal compensation for activities with The Scie...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Zeydan, B., Uygunoglu, U., Tutuncu, M., Yalcinkaya, C., Altintas, A., Saipoglu, S., Siva, A. Tags: General Neurology IV Source Type: research

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular events in patients with clinically stable coronary disease.BackgroundThe presence of activated neutrophils in culprit atherosclerotic plaques of patients with unstable coronary disease raises the possibility that inhibition of neutrophil function with colchicine may reduce the risk of plaque instability and thereby improve clinical outcomes in patients with stable coronary disease.MethodsIn a clinical trial with a prospective, randomized, observer-blinded endpoint design, 532 patients with stable coronary diseas...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - January 21, 2013 Category: Cardiology Source Type: research