Filtered By:
Specialty: Neurology
Countries: USA Health

This page shows you your search results in order of date. This is page number 16.

Order by Relevance | Date

Total 260 results found since Jan 2013.

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research

Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia
Exogenous administration of uric acid, a naturally occurring antioxidant that scavenges reactive oxygen species in vasculature, has shown protective efficacy in both rodent models of stroke and human stroke patients in Spain as an adjuvant treatment to mechanical thrombectomy. Before clinical trials can be initiated in the United States, however, confirmation of efficacy in alternative preclinical models is required in accordance with stroke therapy academic industry roundtable-RIGOR criteria. To date, preclinical efficacy has only been established in the acute setting in male rodents.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2018 Category: Neurology Authors: Nirav Dhanesha, Edwin V ázquez-Rosa, Coral J. Cintrón-Pérez, Daniel Thedens, Alexa J. Kort, Vicky Chuong, Adriana M. Rivera-Dompenciel, Anil K. Chauhan, Enrique C. Leira, Andrew A. Pieper Source Type: research

Historical Slavery and Modern-Day Stroke Mortality in the United States Stroke Belt Comments and Opinions
Source: Stroke - January 22, 2018 Category: Neurology Authors: Charles Esenwa, Daudet Ilunga Tshiswaka, Mulugeta Gebregziabher, Bruce Ovbiagele Tags: Epidemiology, Race and Ethnicity, Risk Factors, Mortality/Survival, Cerebrovascular Disease/Stroke Comments and Opinions Source Type: research

Arsenic Exposure in Relation to Ischemic Stroke Clinical Sciences
Conclusions—A metabolite of arsenic was positively associated with incident ischemic stroke in this case–cohort study of the US general population, a low-to-moderate exposure area. Overall, these findings suggest a potential role for arsenic methylation in the pathogenesis of stroke, having important implications for future cerebrovascular research.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Cari L. Tsinovoi, Pengcheng Xun, Leslie A. McClure, Vivian M.O. Carioni, John D. Brockman, Jianwen Cai, Eliseo Guallar, Mary Cushman, Frederick W. Unverzagt, Virginia J. Howard, Ka He Tags: Epidemiology, Risk Factors, Ischemic Stroke Original Contributions Source Type: research

Informing vs Changing the Practice of Carotid Revascularization
The Carotid Revascularization Endarterectomy vs Stenting Trial (CREST) was a multicenter randomized clinical trial directly comparing the risks and benefits of stenting with those of endarterectomy for symptomatic and asymptomatic high-grade stenosis. Involving 2502 patients across the United States and Canada followed-up for up to 10 years, the trial did not detect significant differences in the end point of perioperative stroke, myocardial infarction, or death or ipsilateral ischemic stroke after the perioperative period. Primary results were published in 2010. CREST clearly informed practice guidelines, but the extent t...
Source: JAMA Neurology - December 4, 2017 Category: Neurology Source Type: research

Novel Algorithm to Help Identify Stroke Mimics
Stroke is a major cause of disability in the United States. A portion of patients presenting with stroke-like symptoms in the emergency room who receive tissue plasminogen activator (tPA) do not end up having a true stroke, leading to unnecessary health-care costs. The aim of our study is to identify those patients who have a high likelihood of experiencing a stroke mimic using a novel stroke mimic score and to identify a cutoff point with a high specificity of ruling in stroke mimics.
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2017 Category: Neurology Authors: Nadeem Israr Khan, Shilpa Chaku, Christina Goehl, Laura Endris, Georgia Mueller-Luckey, Fazeel M. Siddiqui Source Type: research

Big data trends in stroke epidemiology in the United States: But are they good data?
Based on prior epidemiologic studies in the United States, approximately 80% of first-time strokes can be explained by modifiable risk factors such as hypertension, and therefore optimal control or elimination of known risk factors might prevent these strokes.1 Campaigns such as the American Heart Association (AHA) initiative, Life's Simple 7, have set ambitious goals for optimal cardiovascular and stroke risk factor control; in addition, a wealth of online resources are available for an increasingly health-conscious society.2 There are indeed some glimmers of hope. Efforts to prevent stroke, in large part from emphasis on...
Source: Neurology - November 6, 2017 Category: Neurology Authors: Prabhakaran, S. Tags: EDITORIALS Source Type: research

Increasing prevalence of vascular risk factors in patients with stroke: A call to action
Conclusions: Despite numerous guidelines and prevention initiatives, prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in AIS increased across the 2004–2014 period. Proportion of patients with carotid stenosis, CRF, and multiple risk factors also increased. Enhanced risk factor modification strategies and implementation of evidence-based recommendations are needed for optimal stroke prevention.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Otite, F. O., Liaw, N., Khandelwal, P., Malik, A. M., Romano, J. G., Rundek, T., Sacco, R. L., Chaturvedi, S. Tags: Stroke prevention, Embolism, Prevalence studies, Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Patterns and Predictors of Depression Treatment among Stroke Survivors with Depression in Ambulatory Settings in the United States
Despite the importance of treating depression, little is known regarding the current practice pattern of depression treatment among older adults with stroke and depression. We used national survey data from ambulatory settings to examine the depression treatment patterns and predictors among stroke survivors in the United States (US).
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2017 Category: Neurology Authors: Sandipan Bhattacharjee, David Rhys Axon, Lisa Goldstone, Jeannie K. Lee Source Type: research

Clinical and Angiographic Outcomes with the Combined Local Aspiration and Retriever in the North American Solitaire Stent-Retriever Acute Stroke (NASA) Registry
Background: Various techniques are used to enhance the results of mechanical thrombectomy with stent-retrievers, including proximal arrest with balloon guide catheter (BGC), conventional large bore proximal catheter (CGC), or in combination with local aspiration through a large-bore catheter positioned at the clot interface (Aspiration-Retriever Technique for Stroke [ARTS]). We evaluated the impact of ARTS in the North American Solitaire Acute Stroke (NASA) registry.Summary: Data on the use of the aspiration technique were available for 285 anterior circulation patients, of which 29 underwent ARTS technique, 131 CGC, and 1...
Source: Interventional Neurology - October 25, 2017 Category: Neurology Source Type: research

Minimal Clinically Important Difference for Safe and Simple Novel Acute Ischemic Stroke Therapies Clinical Sciences
Conclusions—Stroke expert responses to MCID surveys are affected by anchoring and centrality bias. When survey design takes these into account, the expert-derived MCID for a safe acute ischemic stroke treatment is 1.1% to 1.5%, in accord with actual physician behavior in guideline writing and clinical practice. This revised MCID value can guide clinical trial design and grant-funding and regulatory agency decisions.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Jessica S. Cranston, Brett D. Kaplan, Jeffrey L. Saver Tags: Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Smoking cessation and secondary stroke prevention
The 7 million adult stroke survivors in the United States remain at high risk for a recurrent stroke. The increased morbidity and cost associated with recurrent stroke, in addition to the 5% to 20% yearly stroke recurrence, support the need for additional investigations into secondary stroke prevention.1,2 Stroke prevention guidelines, whether primary or secondary, focus on risk factor control of modifiable risk factors. The American Heart Association/American Stroke Association guidelines for secondary stroke prevention indicate evidence-based risk factor control, interventional approaches, and treatment options as approa...
Source: Neurology - October 16, 2017 Category: Neurology Authors: Boehme, A. Tags: EDITORIALS Source Type: research

Clinical and Angiographic Outcomes with the Combined Local Aspiration and Retriever in the North American Solitaire Stent-Retriever Acute Stroke (NASA) Registry
Background: Various techniques are used to enhance the results of mechanical thrombectomy with stent-retrievers, including proximal arrest with balloon guide catheter (BGC), conventional large bore proximal catheter (CGC), or in combination with local aspiration through a large-bore catheter positioned at the clot interface (Aspiration-Retriever Technique for Stroke [ARTS]). We evaluated the impact of ARTS in the North American Solitaire Acute Stroke (NASA) registry.Summary: Data on the use of the aspiration technique were available for 285 anterior circulation patients, of which 29 underwent ARTS technique, 131 CGC, and 1...
Source: Interventional Neurology - October 10, 2017 Category: Neurology Source Type: research

Striving to improve the quality of stroke care in the USA
Compelling evidence indicates that the organization and delivery of stroke care makes a difference in the chances of patients surviving, their level of disability, and the chances of further strokes. Most evidence-based interventions do not require expensive high-technology medicine but rather need well-organized basic care delivered by people with expertise in stroke. Yet there are many places in the world, including parts of the United States, where high-quality care cannot be guaranteed, resulting in higher than necessary levels of mortality and morbidity.
Source: Neurology - October 9, 2017 Category: Neurology Authors: Rudd, A., Bray, B. Tags: EDITORIALS Source Type: research