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E-125 Clinical outcomes of mechanical thrombectomy in posterior circulation tandem occlusions: multicenter experience
ConclusionMechanical thrombectomy for posterior circulation tandem occlusions is feasible with reasonable clinical outcomes, despite a high rate of rescue stenting.Disclosures M. Salem: None. G. Sioutas: None. M. Mohammaden: None. A. Luisa Kuhn: None. A. Luisa Kuhn: None. A. Luisa Kuhn: None. C. Tschoe: None. M. Tarek: None. A. Dmytriw: None. R. Regenhardt: None. S. Marioni: None. M. AbdalKader: None. G. Cortez: None. V. Srinivasan: None. T. Nguyen: None. S. Tjoumakaris: None. A. Puri: None. V. Pereira: None. J. Rabinov: None. J. Seigler: None. R. Hanel: None. S. Sheth: None. A. Siddiqui: None. E. Levy: None. D. Haussen: N...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Salem, M., Sioutas, G., Mohammaden, M., Luisa Kuhn, A., Luisa Kuhn, A., Luisa Kuhn, A., Tschoe, C., Tarek, M., Dmytriw, A., Regenhardt, R., Marioni, S., AbdalKader, M., Cortez, G., Srinivasan, V., Nguyen, T., Tjoumakaris, S., Puri, A., Pereira, V., Rabino Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-006 Carotid artery revascularization using the walrus balloon guide catheter: safety and feasibility from a US multicenter experience
ConclusionWalrus BGC for proximal flow-control is safe and effective during eCAS and tCAS. Procedural success was achieved in all cases, with favorable safety and functional outcomes on short term follow-up.Disclosures M. Salem: None. S. Kvint: None. A. Baig: None. A. Monteiro: None. G. Cortez: None. A. Luisa Kuhn: None. O. Goren: None. S. Dalal: None. B. Jankowitz: None. O. Choudhri: None. D. Raper: None. O. Tanweer: None. P. Jabbour: None. R. Starke: None. E. Levy: None. C. Griessenauer: None. A. Puri: None. R. Hanel: None. A. Siddiqui: None. J. Burkhardt: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Salem, M., Kvint, S., Baig, A., Monteiro, A., Cortez, G., Luisa Kuhn, A., Goren, O., Dalal, S., Jankowitz, B., Choudhri, O., Raper, D., Tanweer, O., Jabbour, P., Starke, R., Levy, E., Griessenauer, C., Puri, A., Hanel, R., Siddiqui, A., Burkhardt, J. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

O-005 Comparison of on-label versus off-label treatment of intracranial aneurysms with the pipeline embolization devices
ConclusionIn real-world practice, off-label uses of PED can achieve similar safety and efficacy to on-label uses, though there may be a slightly higher rate of ischemic complications in off-label uses. Expert judgment is a useful supplement to official guidelines when assessing reasonable PED use beyond its approved indications.Disclosures S. Cler: None. D. Lauzier: None. A. Kansagra: 2; C; Penumbra, Microvention, iSchemaView.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Cler, S., Lauzier, D., Kansagra, A. Tags: Oral abstracts Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Sex Differences in Sex Hormone Profiles and Prediction of Consciousness Recovery After Severe Traumatic Brain Injury
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - April 25, 2019 Category: Endocrinology Source Type: research

Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Pre-eclampsia through the eyes of the obstetrician and anesthesiologist
Hypertensive disorders of pregnancy (HDP) complicate approximately 5 –10% of pregnancies. In the past 20 years, the incidence of HDPs has increased by 25%.1 These disorders, combined with delayed or inadequate treatment of severe systolic hypertension, continue to be leading causes of maternal death; nearly one woman dies every day in the United States of America (USA) and there are an additional 50–60 000 deaths per year worldwide.2,3 A vast majority of deaths result from hemorrhagic stroke and the complications of seizures.
Source: International Journal of Obstetric Anesthesia - April 12, 2019 Category: Anesthesiology Authors: M.M. Siddiqui, J.M. Banayan, J.E. Hofer Tags: Review article Source Type: research

Preeclampsia through the eyes of the obstetrician and anesthesiologist
Hypertensive disorders of pregnancy (HDP) complicate approximately 5-10% of pregnancies. In the past 20 years the incidence of HDPs has increased by 25%.1 These disorders, combined with delayed or inadequate treatment of severe systolic hypertension, continue to be a leading cause of maternal death – nearly one woman dies every day in the United States of America (USA) and there are an additional 50-60,000 deaths per year worldwide.2,3 A vast majority of deaths result from hemorrhagic stroke and the complications of seizures.
Source: International Journal of Obstetric Anesthesia - April 12, 2019 Category: Anesthesiology Authors: M. Siddiqui, J.M. Banayan, J.E. Hofer Tags: Review article Source Type: research

Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required. Ethics Statement All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Com...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis
Conclusion: We found a statistically insignificant tendency for the ultrasound-measured length of sICAS<70% to be longer than that of sICAS≥70%. Moreover, the ultrasound-measured length of sICAS<90% was significantly longer than that of sICAS 90%. Among patients with sICAS≥70%, the degree and length of stenosis were inversely correlated. Larger studies are needed before a clinical implication can be drawn from these results. Introduction Internal carotid artery stenosis (ICAS) causes around one-fifth of ischemic cerebrovascular stroke and has the highest risk of early stroke recurrence...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research