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Total 340 results found since Jan 2013.

Rural-Urban Disparities in Outcomes of Myocardial Infarction, Heart Failure, and Stroke in the United States
CONCLUSIONS: Clinical, public health, and policy efforts are needed to improve rural-urban gaps in care and outcomes for acute cardiovascular conditions.PMID:35057913 | DOI:10.1016/j.jacc.2021.10.045
Source: Rural Remote Health - January 21, 2022 Category: Rural Health Authors: Em éfah C Loccoh Karen E Joynt Maddox Yun Wang Dhruv S Kazi Robert W Yeh Rishi K Wadhera Source Type: research

Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination-United States, December 2020 to August 2021
CONCLUSION: Thrombosis with thrombocytopenia syndrome is a rare but serious adverse event associated with Ad26.COV2.S vaccination. The different demographic characteristics of the 3 cases reported after mRNA-based COVID-19 vaccines and the much lower reporting rate suggest that these cases represent a background rate.PRIMARY FUNDING SOURCE: Centers for Disease Control and Prevention.PMID:35038274 | DOI:10.7326/M21-4502
Source: Annals of Internal Medicine - January 17, 2022 Category: Internal Medicine Authors: Isaac See Allison Lale Paige Marquez Michael B Streiff Allison P Wheeler Naomi K Tepper Emily Jane Woo Karen R Broder Kathryn M Edwards Ruth Gallego Andrew I Geller Kelly A Jackson Shashi Sharma Kawsar R Talaat Emmanuel B Walter Imo J Akpan Thomas L Ortel Source Type: research

Erectile Dysfunction Associated With Use of E-Cigarettes, Report Finds
This study highlights a novel finding that ENDS use could have serious implications on men’s se xual health.”El-Shahawy and colleagues analyzed data collected from December 2016 to January 2018 as part of thePopulation Assessment of Tobacco or Health (PATH) study —a national longitudinal study of tobacco use and how it affects the health of people in the United States. The researchers specifically focused on male participants 20 years and older who responded to questions about erectile dysfunction; their use of ENDS; current or past history of smoking; and previous diagnoses of diabetes, hypertension, high cholestero...
Source: Psychiatr News - December 7, 2021 Category: Psychiatry Tags: American Journal of Preventive Medicine E-cigarettes erectile dysfunction PATH Study Source Type: research

Risk of Thromboembolic Events and Associated Healthcare Costs in Patients with Inflammatory Bowel Disease
ConclusionsPatients with IBD experienced greater rates of DVT and PE compared to patients without IMD; this elevated risk was associated with a substantial economic burden.
Source: Advances in Therapy - December 7, 2021 Category: Drugs & Pharmacology Source Type: research

Meta ‐analysis of clinical outcomes of PCSK9 modulators in patients with established ASCVD
AbstractThe advent of monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) ushered in a new era of dyslipidemia pharmacotherapy. The first two antibodies targeting PCSK9 (evolocumab, alirocumab) approved by the United States Food and Drug Administration (FDA) provided significant and sustained reductions in atherogenic lipids and a reduced risk of atherosclerotic cardiovascular disease (ASCVD) events. More recently, phase 3 trials of inclisiran —a small interfering RNA-based agent targeting PCSK9—reported similar lipid-lowering effects and preliminary evidence of ASCVD risk reduction, a...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 30, 2021 Category: Drugs & Pharmacology Authors: Azita H. Talasaz, Ai ‐Chen (Jane) Ho, Fawzia Bhatty, Rachel A. Koenig, Dave L. Dixon, William L. Baker, Benjamin W. Van Tassell Tags: TI ON ADVANCES IN CARDIOVASCULAR PHARMACOTHERAPY Source Type: research

IJERPH, Vol. 18, Pages 11284: Examining Predictors of Myocardial Infarction
This study analyzed predictors of myocardial infarction (MI) for those aged 35 and older based on demographic, socioeconomic, geographic, behavioral, and risk factors, as well as access to healthcare variables using the Center for Disease (CDC) Control Behavioral Risk Factor Surveillance System (BRFSS) survey for the year 2019. Multiple quasibinomial models were generated on an 80% training set hierarchically and then used to forecast the 20% test set. The final training model proved somewhat capable of prediction with a weighted F1-Score = 0.898. A complete model based on statistically significant variables using the enti...
Source: International Journal of Environmental Research and Public Health - October 27, 2021 Category: Environmental Health Authors: Diane Dolezel Alexander McLeod Larry Fulton Tags: Article Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Associations Between Active Commuting and Cardiovascular Disease in the United States
CONCLUSION: Significant negative correlations were observed between active commuting and prevalence rates of coronary heart disease, myocardial infarction, and stroke. Controlling for covariates influenced these associations and highlights the need for future research to explore the potential of active commuting modes to reduce CVD in the United States.PMID:34689123 | DOI:10.1123/jpah.2021-0245
Source: Journal of Physical Activity and Health - October 24, 2021 Category: Sports Medicine Authors: James E Peterman David R Bassett W Holmes Finch Matthew P Harber Mitchell H Whaley Bradley S Fleenor Leonard A Kaminsky Source Type: research

Meta ‐Analysis of Clinical Outcomes of PCSK9 Modulators in Patients with Established ASCVD
ConclusionThese findings suggest a class effect for favorable lipid changes and a low risk of serious adverse events among pharmacologic agents targeting PCSK9. Although there is compelling evidence that PCSK9-targeting agents reduce the risk of some cardiovascular outcomes, adequately powered studies with longer follow-up may be needed to fully characterize the magnitude of benefits across the cardiovascular spectrum.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 17, 2021 Category: Drugs & Pharmacology Authors: Azita H. Talasaz, Ai ‐Chen (Jane) Ho, Fawzia Bhatty, Rachel A. Koenig, Dave L. Dixon, William L. Baker, Benjamin W. Van Tassell Tags: TI ON ADVANCES IN CARDIOVASCULAR PHARMACOTHERAPY Source Type: research

Aspirin Use to Prevent 1st Heart Attack or Stroke Should Be Curtailed, U.S. Panel Says
Adults at high risk for cardiovascular disease may face serious side effects if they start a daily regimen of low-dose aspirin.
Source: NYT Health - October 12, 2021 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: Aspirin Preventive Medicine Heart Colon and Colorectal Cancer Stroke Doctors Agency for Healthcare Research and Quality United States Preventive Services Task Force American College of Cardiology American Heart Assn your-feed-healthcar Source Type: news

Trends in early postoperative major adverse cardiovascular and cerebrovascular events associated with bariatric surgery: an analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program data registry
CONCLUSION: The overall risk of MACCE after BaS is .14% and has been declining in the last 5 years. This trend is likely multifactorial and further analysis is necessary to provide a detailed explanation.PMID:34600841 | DOI:10.1016/j.soard.2021.08.023
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - October 3, 2021 Category: Surgery Authors: Roberto J Valera Cristina Botero-Fonnegra Mauricio Sarmiento-Cobos Carlos E Rivera Lisandro Montorfano Rene Aleman Mileydis Alonso Emanuele Lo Menzo Samuel Szomstein Raul J Rosenthal Source Type: research

Debate Update: Surgery After 48 Hours of Admission for Geriatric Hip Fracture Patients Is Associated With Increase in Mortality and Complication Rate: A Study of 27,058 Patients Using the National Trauma Data Bank
Objective: To determine the association between surgical timing and short-term morbidity and mortality in elderly patients who sustain hip fractures using a national trauma database (OTA/AO 31A1-3, 31B1-3). Design: Retrospective cohort study. Setting: Level I–IV trauma centers in the United States. Patients/Participants: All patients ≥65 years of age who underwent surgery for hip fracture from 2011 to 2013. Intervention: Time to surgery of 48 hours from admission. Main outcome measurements: Primary outcome was mortality by hospital discharge. Secondary outcomes were complications ...
Source: Journal of Orthopaedic Trauma - September 23, 2021 Category: Orthopaedics Tags: Original Article Source Type: research