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Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial
Blood Adv. 2023 Feb 3:bloodadvances.2022008539. doi: 10.1182/bloodadvances.2022008539. Online ahead of print.ABSTRACTData from small clinical trials in the USA and India suggest zinc supplementation reduces infection in adolescents and adults with sickle cell anemia (SCA), but no studies of zinc supplementation for infection prevention have been conducted in young children with SCA living in Africa, who have higher infection rates. We conducted a randomized double-blind placebo-controlled trial to assess the effectiveness of zinc supplementation for prevention of severe or invasive infections in Ugandan children 1.00-4.99 ...
Source: Adv Data - February 3, 2023 Category: Epidemiology Authors: Ruth Namazzi Robert O Opoka Andrea L Conroy Dibyadyuti Datta Abner Tagoola Caitlin Bond Michael J Goings Moon-Suhn Ryu Sarah E Cusick Nancy F Krebs Jeong Hoon Jang Wanzhu F Tu Russell E Ware Chandy C John Source Type: research

Brain Magnetic Resonance Imaging and Angiography in Children with Sickle Cell Anaemia in Uganda in a Cross-Sectional Sample
Children with sickle cell anaemia (SCA) are highly susceptible to cerebrovascular injury. We performed brain magnetic resonance imaging and angiography (MRI-MRA) in Ugandan children with SCA to identify structural cerebrovascular abnormalities and examine their relationship to standardized clinical assessments.
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2022 Category: Neurology Authors: Richard Idro, Amelia K. Boehme, Michael Kawooya, Samson K. Lubowa, Deogratias Munube, Paul Bangirana, Robert Opoka, Ezekiel Mupere, Angela Lignelli, Philip Kasirye, Nancy S. Green, Frank J. Minja Source Type: research

Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study
Children with sickle cell anemia (SCA) are highly susceptible to stroke and other manifestations of pediatric cerebral vasculopathy. Detailed evaluations in sub-Saharan Africa are limited.
Source: BMC Pediatrics - October 25, 2019 Category: Pediatrics Authors: Nancy S. Green, Deogratias Munube, Paul Bangirana, Linda Rosset Buluma, Bridget Kebirungi, Robert Opoka, Ezekiel Mupere, Philip Kasirye, Sarah Kiguli, Annet Birabwa, Michael S. Kawooya, Samson K. Lubowa, Rogers Sekibira, Edwards Kayongo, Heather Hume, Mit Tags: Research article Source Type: research

Hydroxyurea to lower TCD velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort.
Abstract *_. PMID: 31649130 [PubMed - as supplied by publisher]
Source: Haematologica - October 23, 2019 Category: Hematology Authors: Opoka RO, Hume HA, Latham TS, Lane A, Williams O, Tymon J, Nakafeero M, Kasirye P, Ndugwa CM, John CC, Ware RE Tags: Haematologica Source Type: research

Burden and Risk of Neurological and Cognitive Impairment in Pediatric Sickle Cell Anemia in Uganda (BRAIN SAFE): Final Results of the Cross-Sectional Analysis
Conclusions: These data demonstrate early, frequent neurovascular pathology for each outcome tested. Abnormal neurocognitive test results significantly increased with age or non-normal TCD. Our findings provide a baseline for longitudinal assessment and incentive for intervention. Enhanced research capacity was gained for junior faculty, trainees and staff, in areas of the conduct of brain research and focus on pediatric SCD, TCD performance and neuro-epidemiology.Funding: 1R21HD089791 (PIs: Idro, Green)DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Green, N. S., Munube, D., Bangirana, P., Opoka, R., Kayongo, E., Mupere, E., Buluma, L. R., Kebirungi, B., Sekibira, R., Kiguli, S., Kawooya, M., Lubowa, S. K., Elkind, M. S. V., Li, G., LaRussa, P., Idro, R. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster II Source Type: research

Brain Magnetic Resonance Imaging and Angiography Findings in Ugandan Children with Sickle Cell Anemia; A Cross Sectional Study
ConclusionsBrain injury in Uganda children with SCA begins early in childhood and becomes a common finding during later childhood. Early screening for stroke and intervention therapy is warranted to prevent sickle brain vasculopathy initiated early after diagnosis. The risk factors for such early brain injury should be investigated.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Idro, R., Green, N. S., Munube, D., Buluma, L. R., Kebirungi, B., Opoka, R., Bangirana, P., Mupere, E., Kayongo, E., Sekibira, R., Kasirye, P., Lubowa, S. K., Kawooya, M., LaRussa, P., Minja, F. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster II Source Type: research

Realizing Effectiveness Across Continents with Hydroxyurea: Enrollment and Baseline Characteristics of the Multicenter REACH Study in sub ‐Saharan Africa
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - January 10, 2018 Category: Hematology Authors: Patrick T. McGann, Thomas N. Williams, Peter Olupot ‐Olupot, George A. Tomlinson, Adam Lane, José Luís Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Thad A. Howard, Kathryn McElhinney, Banu Aygun, Teresa Latham, Brígida Tags: Research Article Source Type: research