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Efficacy and Safety of Ticagrelor versus Clopidogrel in East Asian Patients with Acute Myocardial Infarction: A Nationwide Cohort Study.
This study aimed to compare the efficacy and safety of ticagrelor versus clopidogrel in East Asian patients with AMI. Between July 2013 and December 2015, patients with AMI prescribed with dual antiplatelet therapy were identified from the National Health Insurance Research Database of Taiwan. Using propensity score weighting, ticagrelor was compared with clopidogrel for the primary efficacy endpoint (a composite of all-cause death, MI, and stroke) and bleeding. A total of 32,442 patients with AMI (ticagrelor: 10,057; clopidogrel: 22,385) were eligible for analysis. After propensity score weighting, ticagrelor was comparab...
Source: Clinical Pharmacology and Therapeutics - August 6, 2020 Category: Drugs & Pharmacology Authors: Chang CJ, Tung YC, Liu JR, Chang SH, Kuo CT, See LC Tags: Clin Pharmacol Ther Source Type: research

Endocrine Dysfunction Following Stroke
In conclusions, stroke survivors have an approximately 2-fold increased risk of developing acquired hypothyroidism, pituitary dysfunction, or disorders of the adrenal glands. These ris ks should be taken into account in the management of patients who have ischemic or hemorrhagic strokes.Graphical Abstract
Source: Journal of NeuroImmune Pharmacology - July 2, 2020 Category: Drugs & Pharmacology Source Type: research

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis
We performed a retrospective cohort study to investigate the association between the risk of ischemic stroke (IS) and the use of Chinese herbal products (CHP) in combination with western medicine (WM) among patients with rheumatoid arthritis (RA). The data were sourced from the registry for beneficiaries, inpatient and ambulatory care claims, and Registry for Catastrophic Illness from the National Health Insurance Research Database (NHIRD) in Taiwan between 1997 and 2011. Patients, who were newly diagnosed with RA between 1997 and 2010, were classified as the CHP group or non-CHP group depending on the presence of absence ...
Source: Frontiers in Pharmacology - March 3, 2020 Category: Drugs & Pharmacology Source Type: research

Comparative Effectiveness and Safety of Rivaroxaban in Adults With Nonvalvular Atrial Fibrillation
Conclusions: Research on the long-term comparative effectiveness, safety, and effects on quality of life between rivaroxaban and other novel oral anticoagulants is urgently needed.
Source: American Journal of Therapeutics - November 1, 2019 Category: Drugs & Pharmacology Tags: Review Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Comparative cardiovascular safety of nonsteroidal anti ‐inflammatory drugs in patients with hypertension: a population‐based cohort study
ConclusionsOur results provide important information about the comparative cardiovascular safety of NSAIDs in patients with hypertension.
Source: British Journal of Clinical Pharmacology - March 13, 2018 Category: Drugs & Pharmacology Authors: Yaa ‐Hui Dong, Chia‐Hsuin Chang, Li‐Chiu Wu, Jing‐Shiang Hwang, Sengwee Toh Tags: DRUG SAFETY Source Type: research

Comparative cardiovascular safety of non ‐steroidal anti‐inflammatory drugs in patients with hypertension: a population‐based cohort study
ConclusionsOur results provide important information about the comparative cardiovascular safety of NSAIDs in patients with hypertension.
Source: British Journal of Clinical Pharmacology - February 22, 2018 Category: Drugs & Pharmacology Authors: Yaa ‐Hui Dong, Chia‐Hsuin Chang, Li‐Chiu Wu, Jing‐Shiang Hwang, Sengwee Toh Tags: DRUG SAFETY Source Type: research

Concurrent use of Chinese herbal medicine among hormone users and its association with ischemic stroke risk: A population-based study
Conclusion We found that combined use of HT and CHM was associated with a lower risk of IS. Further study is needed to examine possible mechanism underlying this association. Graphical abstract
Source: Journal of Ethnopharmacology - February 15, 2018 Category: Drugs & Pharmacology Source Type: research

Risks of newly onset hemorrhagic stroke in patients with neovascular age ‐related macular degeneration
ConclusionsPatients with nAMD had a significantly higher risk of developing stroke, which was driven mainly by the increased risk of developing the hemorrhagic subtype.
Source: Pharmacoepidemiology and Drug Safety - August 30, 2017 Category: Drugs & Pharmacology Authors: Wan ‐Ju Annabelle Lee, Ching‐Lan Cheng, Cheng‐Han Lee, Yea‐Huei Kao Yang, Swu‐Jane Lin, Cheng‐Yang Hsieh Tags: ORIGINAL REPORT Source Type: research

Previously undiagnosed risk factors and medication nonadherence are prevalent in young adults with first ‐ever stroke
ConclusionsPreviously undiagnosed hypertension and nonadherence to treatment of hypertension and diabetes were more prevalent in young adult patients with first‐ever stroke in Taiwan. Interventions targeting young people to promote early detection and adequate control of VRFs should be encouraged.
Source: Pharmacoepidemiology and Drug Safety - July 1, 2017 Category: Drugs & Pharmacology Authors: Sheng ‐Feng Sung, Edward Chia‐Cheng Lai, Darren Philbert Wu, Cheng‐Yang Hsieh Tags: ORIGINAL REPORT Source Type: research

Cost-Effectiveness Analysis of Apixaban, Dabigatran, Rivaroxaban, and Warfarin for Stroke Prevention in Atrial Fibrillation in Taiwan
ConclusionsApixaban was more cost effective than warfarin, dabigatran, and rivaroxaban for stroke prevention in patients with AF. Among the anticoagulant therapies, the WTP threshold of apixaban was about US$50,000 per QALY gained. These cost-effectiveness estimations provide useful information to aid clinical decision making in stroke prevention for AF patients.
Source: Clinical Drug Investigation - December 16, 2016 Category: Drugs & Pharmacology Source Type: research

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