• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

E-005 Preliminary results of the SUMMIT NZ ischemic stroke trial: MonoPoint(R) embolectomy featuring a novel 088 aspiration catheter and specialized delivery catheter
ConclusionsPreliminary findings suggest that first-line aspiration embolectomy using a novel MonoPoint® system including an 0.088" inner diameter aspiration catheter achieves a high rate of arterial revascularization with an acceptable safety profile. A full report on enrollment and results are to be presented.Disclosures S. Brew: 1; C; Route 92 Medical. 2; C; Route 92 Medical, Microvention. B. McGuinness: 1; C; Route 92 Medical. 2; C; Route 92 Medical. J. Caldwell: 1; C; Route 92 Medical. 2; C; Route 92 Medical. S. Lee: 1; C; Route 92 Medical. P. Barber: None. A. Holden: 2; C; Medtronic, Gore, Boston Scientific. T. Wu...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Brew, S., McGuinness, B., Caldwell, J., Lee, S., Barber, P., Holden, A., Wu, T., Krauss, M., Laing, A., Collecutt, W., Liebeskind, D., Hetts, S. Tags: Electronic poster abstracts Source Type: research

Anticoagulant-related intracranial haemorrhage: time to anticoagulant reversal improving but still slower than thrombolysis for ischaemic stroke.
CONCLUSION: Door-to-any-reversal-agent and scan-to-PCC times have improved over time, but they remain significantly longer than IS thrombolysis times. Monitoring of reversal is inadequate, particularly for WRICH receiving PCC. PMID: 33582709 [PubMed - in process]
Source: New Zealand Medical Journal - February 17, 2021 Category: General Medicine Tags: N Z Med J Source Type: research

Tocilizumab Reduces Vasospasms, Neuronal Cell Death, and Microclot Formation in a Rabbit Model of Subarachnoid Hemorrhage
AbstractEarly brain injury (EBI), delayed cerebral vasospasm (DCVS), and delayed cerebral ischemia (DCI) are common complications of subarachnoid hemorrhage (SAH). Inflammatory processes in the cerebrospinal fluid (CSF) are one of the causes for such complications. Our aim to study the effects of an IL-6 receptor antagonist (Tocilizumab) examines the occurrence of DCVS, neuronal cell death, and microclot formation in an acute SAH rabbit model. Twenty-nine New Zealand white rabbits were randomized into one of three groups as the SAH, SAH + Tocilizumab, and sham groups. In SAH groups, hemorrhage was induced by extracranial-i...
Source: Translational Stroke Research - January 6, 2021 Category: Neurology Source Type: research

Inducing ketogenesis via an enteral formulation in patients with acute brain injury:a phase II study.
Conclusion: In patients with acute brain injury, an enterally administered ketogenic formulation increased plasma ketone concentrations, was well tolerated, did not impact on cerebral hemodynamics and can be safely administered.Clinical trial registered at the Australian New Zealand Clinical Trials Registry (ACTRN12616000332426)Abbreviations: BHB: betahydroxybutyrate; AcAc: acetoacetate; ABI: acute brain injury; TBI: traumatic brain injury; CSF: cerebrospinal fluid; SAH: subarachnoid injury; CVA: cerebrovascular accidents; ICP: intracranial pressure; CPP: cerebral perfusion pressure; ICU: intensive care unit; EVD: external...
Source: Neurological Research - February 28, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Iron nanoparticle contrast enhanced microwave imaging for emergent stroke: A pilot study
Publication date: Available online 1 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Joseph S. Hudson, Timothy K. Chung, Benjamin S. Prout, Yasunori Nagahama, Madhavan L. Raghavan, David M. HasanAbstractEmergent stroke is mostly evaluated using hospital based imaging. Quick imaging allows for rapid administration of IV thrombolysis and outcome improvement. Microwave imaging (MI) is an emerging portable imaging modality. Iron oxide nanoparticles are known to interact with microwave frequency electromagnetic radiation. In this manuscript, we provide proof of concept for a novel iron oxide nanoparticle enhance...
Source: Journal of Clinical Neuroscience - November 2, 2018 Category: Neuroscience Source Type: research

Tenecteplase versus alteplase in acute ischemic stroke: systematic review and meta-analysis
AbstractTenecteplase is a product of genetic modification of recombinant tissue plasminogen activator with superior pharmacodynamic and pharmacokinetic properties. This meta-analysis was to determine whether intravenous thrombolysis with tenecteplase in patients with acute ischemic stroke has better efficacy and safety outcomes than with intravenous alteplase. PubMed, Cochrane Central Register of Controlled Trials, WHO International clinical trials registry platform (ICTRP), Australian New Zealand Clinical Trials Registry (ANZCTR), EU Clinical Trials Register (EU-CTR) and ClinicalTrials.gov were searched for trials compari...
Source: Acta Neurologica Belgica - May 4, 2018 Category: Neurology Source Type: research

Embolisation for pulmonary arteriovenous malformation.
CONCLUSIONS: There is no evidence from randomised controlled trials for embolisation of pulmonary arteriovenous malformations. However, randomised controlled trials are not always feasible on ethical grounds. Accumulated data from observational studies suggest that embolisation is a safe procedure which reduces morbidity and mortality. A standardised approach to reporting with long-term follow-up through registry studies can help to strengthen the evidence for embolisation in the absence of randomised controlled trials. PMID: 29298459 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 4, 2018 Category: General Medicine Authors: Hsu CC, Kwan GN, Evans-Barns H, van Driel ML Tags: Cochrane Database Syst Rev Source Type: research

Trends in New Zealand stroke thrombolysis treatment rates.
CONCLUSIONS: There have been improvements in stroke thrombolysis rates and treatment delays in New Zealand hospitals since the institution of the National Stroke Network thrombolysis register. The Network will continue to adjust key performance indicators, and stroke thrombolysis targets for individual DHBs have been increased to 8% for 2017 and 10% for 2018. PMID: 28384147 [PubMed - in process]
Source: New Zealand Medical Journal - April 8, 2017 Category: Journals (General) Tags: N Z Med J Source Type: research

Stroke thrombolysis in New Zealand: data from the first 6 months of the New Zealand Thrombolysis Register.
Authors: Joshi P, Fink J, Barber PA, Davis A, Lanford J, Seymour A, Wright P, Busby W, Abernethy G, Ranta AA Abstract The New Zealand National Stroke Network introduced a National Stroke Thrombolysis Register on the first of January 2015 to assist with quality assurance and continuous service improvement. In the first 6 months, there were 179 [75 women, mean (SD) age 69.9 (14) years] treated with stroke thrombolysis out of a total of 2,796 ischaemic stroke patients, giving a national thrombolysis rate of 6.4%. The median [Inter-quartile range (IQR)] onset-to-treatment time was 154 (125-190) minutes, and the median ...
Source: New Zealand Medical Journal - July 25, 2016 Category: Journals (General) Tags: N Z Med J Source Type: research

Prospective surveillance of hospitalisations associated with varicella in New Zealand children
ConclusionVaricella has more associated morbidity than commonly perceived in immunocompetent children. Māori and PI children are more likely to have complications. This surveillance gives support for inclusion of universal varicella vaccine in the NZ NIS.
Source: Journal of Paediatrics and Child Health - June 3, 2015 Category: Pediatrics Authors: Sophie Chien‐Hui Wen, Emma Best, Tony Walls, Nigel Dickson, Hamish McCay, Elizabeth Wilson Tags: Original Article Source Type: research

Pages: 1  2