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Long-term effect of field triage on times to endovascular treatment for emergent large vessel occlusion
Conclusions Comparing adjacent states over time, the implementation of severity-based field triage significantly reduced time to EVT.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Jayaraman, M. V., Baird, G., Oueidat, K., Paolucci, G., Haas, R. A., Torabi, R., Moldovan, K., Rhodes, J., Potvin, J., Alexander-Scott, N., Yaghi, S., Madsen, T., Furie, K., McTaggart, R. A. Tags: Ischemic stroke Source Type: research

Recurrence risk in symptomatic intracranial stenosis treated medically in the real world
CONCLUSIONS: In patients with symptomatic ICAS, the real-world recurrence of ischemic events is higher than that seen in clinical trials, even in subgroups receiving the same pharmacological treatment strategies.PMID:37030126 | DOI:10.1016/j.jstrokecerebrovasdis.2023.107086
Source: Atherosclerosis - April 8, 2023 Category: Cardiology Authors: Shadi Yaghi Liqi Shu Eric D Goldstein Allison Chang Narendra Kala Christoph Stretz Tina M Burton Elizabeth Perelstein Karen Furie Mahesh Jayaraman Radhmer Torabi Krisztina Moldovan Adam de Havenon Pooja Khatri Mulugeta Gebregziabher David S Liebeskind Shy Source Type: research

Dual antiplatelet use in the management of COVID-19 associated acute ischemic stroke reocclusion
CONCLUSION: COVID-19 AIS may be associated with a hypercoagulable state which risks malignant reocclusion complicating MT. We found antithrombotic treatment periprocedural cangrelor with or without argatroban transitioned to oral aspirin with ticagrelor to be a viable method for management of these patients.PMID:35549746 | DOI:10.1177/15910199221097484
Source: Interventional Neuroradiology - May 13, 2022 Category: Radiology Authors: Joshua Feler Carlin Chuck Matthew Anderson Jonathan Poggi Joseph Sweeney Krisztina Moldovan Mahesh V Jayaraman Ryan McTaggart Radmehr Torabi Source Type: research

Pre-hospital Triage of Acute Ischemic Stroke Patients —Importance of Considering More Than Two Transport Options
Conclusion: Pre-hospital triage algorithms for AIS patients that only take into account the nearest CSC and the nearest PSC as transport destinations may be unable to identify the optimal transport destination for a significant proportion of patients. Introduction Background International guidelines recommend early administration of intravenous thrombolysis for eligible patients with acute ischemic stroke (AIS); in addition, patients with proximal large vessel occlusion (LVO) should receive mechanical thrombectomy (MT) as quickly as possible (1). As the clinical benefit of both thrombolysis (2–4) and MT (5&#...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

The role of microwave radiometry in carotid artery disease. Diagnostic and clinical prospective.
Abstract Atherosclerosis of the internal carotid artery is an important cause of disabling ischemic stroke and therefore constitutes a major medical, social, and economic issue. Although advances in vascular imaging modalities during the last decades allow to risk stratify patients not solely on the degree of carotid artery stenosis but also based on 'high risk' features, there still remains a controversy over patient selection for carotid artery revascularization. Among other features of plaque vulnerability, there is an increasing body of evidence that inflammation is a key factor in the initiation, progression ...
Source: Current Opinion in Pharmacology - April 6, 2018 Category: Drugs & Pharmacology Authors: Drakopoulou M, Moldovan C, Toutouzas K, Tousoulis D Tags: Curr Opin Pharmacol Source Type: research

Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis.
Conclusions -Both general and central adiposity have causal effects on CHD and T2D. Central adiposity may have a stronger effect on stroke risk. Future estimates of the burden of adiposity on health should include measures of central and general adiposity. PMID: 28500271 [PubMed - as supplied by publisher]
Source: Circulation - May 12, 2017 Category: Cardiology Authors: Dale C, Fatemifar G, Palmer T, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan Tags: Circulation Source Type: research

Timing of Anticoagulant Re-Initiation following Intracerebral Hemorrhage in Mechanical Heart Valves: Survey of Neurosurgeons and Thrombosis Experts
While oral anticoagulation is universally recommended among patients with mechanical heart valves (MHVs) [1], there is limited evidence to guide clinicians in managing patients who suffer intracerebral hemorrhage (ICH), a feared complication of anticoagulant treatment estimated to occur at 2-3% per patient-year [2]. In particular, the timing of oral anticoagulant (OAC) re-initiation following stabilization of hemorrhage is challenged by the intricate need to balance the risks of valve thrombosis and ischemic stroke with those of recurrent bleeding.
Source: Clinical Neurology and Neurosurgery - January 13, 2017 Category: Neurosurgery Authors: Fahad AlKherayf, Yan Xu, Harrison Westwick, Ioana Doina Moldovan, Philip S. Wells Source Type: research

Post-stroke gaseous hypothermia increases vascular density but not neurogenesisin the ischemic penumbra of aged rats.
CONCLUSION: Long-term hypothermia may be a viable clinical approach by simultaneously targeting multiple processes including better tissue preservation, enhanced vascular density and improved behavioral performance. PMID: 26923618 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - March 1, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Low-frequency rTMS in patients with subacute ischemic stroke: clinical evaluation of short and long-term outcomes and neurophysiological assessment of cortical excitability.
This study is the first to measure the dynamics of cortical excitability by TMS mapping before and after treatment with low-frequency (LF) rTMS in the contralesional hemisphere at three different timepoints. Furthermore, the patients were clinically evaluated during the same visit as the mapping to establish both short and long-term outcomes after rTMS treatment. METHODS AND RESULTS: A total of 16 participants with acute ischemic stroke were assessed 10 days post-stroke by TMS mapping. The patients were randomized into two equal groups: a real rTMS group and a sham group. The rTMS group received LF-rTMS to the contrale...
Source: Journal of Medicine and Life - November 18, 2015 Category: Journals (General) Tags: J Med Life Source Type: research