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Predictors of Recurrent Ischemic Stroke in Obese Patients With Type 2 Diabetes Mellitus: A Population-based Study
Each year, approximately 0.8 million people are estimated to experience a new or recurrent stroke, according to the 2019 report of the American Heart Association.1 In Malaysia, stroke is the third leading cause of death after ischemic heart disease (IHD) and pneumonia.2 Both obesity and diabetes are considered as the established independent risk factors for ischemic stroke.3 Type 2 diabetes mellitus (T2DM) was also found to be associated with an increase in all-cause as well as cardiovascular mortality following the stroke,4,5 and in a meta-analysis of 18 studies, patients with diabetes had a higher stroke recurrence as co...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Orwa Albitar, Sabariah Noor Harun, Nur Ezzati Abidin, Balamurugan Tangiisuran, Hadzliana Zainal, Irene Looi, Khairul Azmi Ibrahim, Norsima Nazifah Sidek, Keat Wei Loo, Keng Yee Lee, Zariah Abdul Aziz, Siti Maisharah Sheikh Ghadzi Source Type: research

Predictors of functional outcome in patients with stroke thrombolysis in a tertiary hospital in Malaysia.
CONCLUSION: Our newly developed Malaysian IV rt-PA service is safe, with similar outcomes to the published literature. Functional outcome after thrombolysis was associated with baseline NIHSS scores and DM. PMID: 30488077 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - November 29, 2018 Category: General Medicine Authors: Tai MS, Goh KJ, Kadir KAA, Zakaria MI, Yap JF, Tan KS Tags: Singapore Med J Source Type: research

Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study
Conclusion: Periodontal disease is significantly and positively correlated with increased risk of hypertension in Chinese population, and exact mechanisms of this association should be explored in future. Introduction Periodontal disease is a complex polymicrobial inflammation, including gingivitis and periodontitis. According to the 2015 Global Burden of Disease (GBD) study, the prevalence of severe chronic periodontitis in 2015 has reached 616 million (Kassebaum et al., 2017). In China, the periodontal disease standardized DALYs rate has risen from 24.7 in 1990 to 25.7 in 2013 according to the data from 2013 GBD ...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Prevalence of atrial fibrillation in the Malaysian communities
Conclusions The prevalence of AF in the Malaysian population was low at 0.54% compared to the global average of 1%. We found that AF was associated with older age, male sex, hypertension, and ischaemic heart disease.
Source: Heart Asia - November 17, 2016 Category: Cardiology Authors: Lim, C. W., Kasim, S., Ismail, J. R., Chua, N. Y. C., Najme Khir, R., Zainal Abidin, H. A., Abdul Rahman, E., Mohd Arshad, M. K., Ibrahim Othman, Z., Yusoff, K. Tags: Original research Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Factors of Health Promotion Behaviour (HPB) and Elderly Health Diseases in Malaysia
This study, therefore, is to investigate the effect of factors of HPB on elderly health disease in Malaysia. The factors of HPB are measured in 6 aspects, namely, healthy eating, exercise, stress management, interpersonal relations, health responsibility and spiritual growth. A set of 520 survey questionnaires was distributed and collected from respondents located in Perak, Malacca, Penang and Selangor. The statistical analysis result is analysed by using SmartPLS Software 3.0. The data analysis implicated that, elderly health disease is significantly affected by the factors of HPB (healthy eating, exercise, Interpersonal ...
Source: Journal of Population Ageing - June 2, 2020 Category: International Medicine & Public Health Source Type: research

Investigating the prevalence of diabetic complications in overweight/obese patients: a study in a tertiary hospital in Malaysia
ConclusionIn our study, a BMI of more than 23  kg/m2 (obese/overweight) does not seem to be associated with the prevalence of complications. Age and hypertension, on the other hand, appear to be strong risk predictors of the incidence of complications. With the understanding of the recent outlook on diabetes, it is recommended that public education on the targeted population should be encouraged to negate these complications.
Source: International Journal of Diabetes in Developing Countries - September 30, 2022 Category: Endocrinology Source Type: research

Prevalence of and factors associated with multimorbidity among 18 101 adults in the South East Asia Community Observatory Health and Demographic Surveillance System in Malaysia: a population-based, cross-sectional study of the MUTUAL consortium
Conclusions The current single-disease services in primary and secondary care should be accompanied by strategies to address complexities associated with multimorbidity, taking into account the factors associated with multimorbidity identified. Future research is needed to identify the most commonly occurring clusters of chronic diseases and their risk factors to develop more efficient and effective multimorbidity prevention and treatment strategies.
Source: BMJ Open - December 23, 2022 Category: General Medicine Authors: Tan, M. M. C., Prina, A. M., Muniz-Terrera, G., Mohan, D., Ismail, R., Assefa, E., Keinert, A. A. M., Kassim, Z., Allotey, P., Reidpath, D., Su, T. T. Tags: Open access, Epidemiology Source Type: research