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Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
Biomed Pharmacother. 2021 Nov 5:112138. doi: 10.1016/j.biopha.2021.112138. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several complications are associated with DM including heart attack, stroke, kidney failure, blindness, and cancer. The latter is the second leading cause of death worldwide accounting for one in every six deaths, with liver, pancreas, and endometrium cancers are the most abundant among patients with diabetes. Phosphoinositide 3-kinase (PI3K)/prote...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 9, 2021 Category: Drugs & Pharmacology Authors: Agustina Dwi Retno Nurcahyanti Adeline Jap Jullietta Lady Deka Prismawan Farukh Sharopov Rachid Daoud Michael Wink Mansour Sobeh Source Type: research

Safety of intravenous thrombolysis and mechanical thrombectomy in bilateral posterior cerebral artery territory infarction
CONCLUSION: Even if there is no randomized controlled trial to compare the effectiveness and safety of mechanical thrombectomy (MT) to intravenous thrombolysis in patients with posterior circulation occlusion, the good outcome of this case encourages combined stroke treatments in posterior circulation stroke, even in case of mild but disabling neurological deficits.PMID:34629044 | DOI:10.2174/1574886316666211008140212
Source: Current Drug Safety - October 11, 2021 Category: Drugs & Pharmacology Authors: Maurizio Acampa Francesca Guideri Sandra Bracco Rossana Tassi Carlo Domenichelli Pietro Enea Lazzerini Samuele Cioni Giuseppe Martini Source Type: research

Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues
Ischemic retinopathies represent a major cause of visual impairment and blindness. They include diabetic retinopathy (DR), acute glaucoma, retinopathy of prematurity (ROP), and central (or branch) retinal artery occlusion (CRAO). These conditions share in common a period of ischemia or reduced blood supply to the retinal tissue that eventually leads to neuronal degeneration. Similarly, acute brain injury from ischemia or trauma leads to neurodegeneration and can have devastating consequences in patients with stroke or traumatic brain injury (TBI). In all of these conditions, current treatment strategies are limited by thei...
Source: Frontiers in Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

The Association Between Type 2 Diabetes and Cardiovascular Disease: The “For Your SweetHeart™” Survey
ConclusionsFindings indicate that education regarding the association between T2DM and CVD in patients and their loved ones is warranted.Plain Language SummaryPlain language summary available for this article. Please see Fig. 1 and the following link:https://doi.org/10.6084/m9.figshare.7546817.FundingThe “For Your SweetHeart™” survey was supported by the Boehringer Ingelheim& Eli Lilly and Company Diabetes Alliance, and was developed in partnership with KRC Research.
Source: Advances in Therapy - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Tannins and Vascular Complications of Diabetes: An update
ConclusionThis review focuses on the role of various tannins in prevention and management of diabetic complications like diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and diabetic cardiomyopathy. It will researchers to find some leads for the development of new cost effective therapy using dietary source for the management of diabetic complications.Graphical abstract
Source: Phytomedicine - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

Risks of newly onset hemorrhagic stroke in patients with neovascular age ‐related macular degeneration
ConclusionsPatients with nAMD had a significantly higher risk of developing stroke, which was driven mainly by the increased risk of developing the hemorrhagic subtype.
Source: Pharmacoepidemiology and Drug Safety - August 30, 2017 Category: Drugs & Pharmacology Authors: Wan ‐Ju Annabelle Lee, Ching‐Lan Cheng, Cheng‐Han Lee, Yea‐Huei Kao Yang, Swu‐Jane Lin, Cheng‐Yang Hsieh Tags: ORIGINAL REPORT Source Type: research

Role of natural herbs in the treatment of hypertension.
Authors: Tabassum N, Ahmad F Abstract Hypertension (HTN) is the medical term for high blood pressure. It is dangerous because it makes the heart work too hard and contributes to atherosclerosis (hardening of arteries), besides increasing the risk of heart disease and stroke. HTN can also lead to other conditions such as congestive heart failure, kidney disease, and blindness. Conventional antihypertensives are usually associated with many side effects. About 75 to 80% of the world population use herbal medicines, mainly in developing countries, for primary health care because of their better acceptability with huma...
Source: Pharmacognosy Reviews - November 25, 2014 Category: Drugs & Pharmacology Tags: Pharmacogn Rev Source Type: research