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Condition: Atrial Fibrillation
Drug: Activase
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Total 47 results found since Jan 2013.
Effect of Intravenous Thrombolytic Dose of Alteplase on Long-Term Prognosis in Patients with Acute Ischemic Stroke
ConclusionsStandard-dose alteplase treatment reduced the risk of long-term recurrence of AIS after hospital discharge and the alteplase dose was not associated with the long-term risk of death from AIS.
Source: Neurology and Therapy - May 11, 2023 Category: Neurology Source Type: research
Thrombectomy with or without Bridging Thrombolysis for Anterior Circulation Stroke
Conclusions: In this study, BT seems to yield better clinical and procedural outcomes with lower complication rates than d-MT. These findings may support the additional value of intravenous alteplase in anterior system strokes. Further large-scale, prospective, randomized-controlled studies will clarify the gray lines in this consensus, but this paper is important for reflecting the real-world data in developing countries.
Source: Neurology India - April 29, 2023 Category: Neurology Authors: Leyla Ramazanoglu Mehmet Kocak Isil Kalyoncu Aslan Yilmaz Onal Murat Velioglu Eren Gozke Source Type: research
Thrombectomy with or without Bridging Thrombolysis for Anterior System Stroke
Conclusions: In this study, BT seems to yield better clinical and procedural outcomes with lower complication rates than d-MT. These findings may support the additional value of intravenous alteplase in anterior system strokes. Further large-scale, prospective, randomized-controlled studies will clarify the gray lines in this consensus, but this paper is important for reflecting the real-world data in developing countries.
Source: Neurology India - April 29, 2023 Category: Neurology Authors: Leyla Ramazanoglu Mehmet Kocak Isil Kalyoncu Aslan Yilmaz Onal Murat Velioglu Eren Gozke Source Type: research
No sex difference was found in the safety and efficacy of intravenous alteplase before endovascular therapy
ConclusionOur study could not confirm that sex modifies the treatment effect of intravenous alteplase before endovascular therapy. At the same time, we advocate for women to seek timely medical treatment.
Source: Frontiers in Neurology - November 9, 2022 Category: Neurology Source Type: research
P-024 Balloon guide catheter use for stroke intervention: does the access site matter?
ConclusionsPatients treated with MT via TFA or sTRA had similar angiographic and clinical outcomes, differing only in the rate of crossover from one approach to another.Abstract P-024 Table 1TFA and sTRA Variable RadialN=30 FemoralN=63 P-value Age; mean (SD) 70.9 (13.9) 72.7 (11.4) 0.504 Women, n (%) 13 (43.3) 35 (55.6) 0.375 Diabetes, n (%) 7 (23.3) 18 (28.6) 0.629 Hypertension, n (%) 22 (73.3) 52 (82.5) 0.409 Hyperlipidemia, n (%) 18 (60) 30 (47.6) 0.278 Atrial fibrillation, n (%) 13 (43.3) 24 (38.1) 0.656 NIHSS at admission; mean (SD) 15 (8) 16 (6) 0.131 Intravenous alteplase, n (%) 10 (33.3) 20 (31.7) 1 ICA occlusion,...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Waqas, M., Monteiro, A., Cappuzzo, J., Dossani, R., Almayman, F., Metcalf-Doetsch, W., Snyder, K., Davies, J., Siddiqui, A., Levy, E. Tags: SNIS 19th annual meeting oral poster abstracts Source Type: research
P-030 Mechanical thrombectomy in medium vessel occlusions using the novel aspiration MIVI Q catheters: an international multicenter experience
ConclusionsTreatment of MeVO patients with Q catheters resulted in optimal angiographic and clinical outcomes. Though angiographic results were similar between primary and secondary MeVOs, the first had less severe presentation and better outcomes at 90-days than the latter.Disclosures A. Monteiro: None. L. Makalanda: None. J. Wareham: None. J. Jones: None. P. Dhillon: None. P. Bhogal: None. W. Brinjikji: None. M. Mokin: None. A. Siddiqui: 1; C; Co-investigator for NIH – 1R01EB030092–01, Project Title: High Speed Angiography at 1000 frames per second; Mentor for Brain Aneurysm Foundation Carol W. Harvey Chair o...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Monteiro, A., Makalanda, L., Wareham, J., Jones, J., Dhillon, P., Bhogal, P., Brinjikji, W., Mokin, M., Siddiqui, A. Tags: SNIS 19th annual meeting oral poster abstracts Source Type: research
Use of Oral Anticoagulants and Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke
To the Editor A recent study examined the safety of intravenous alteplase in patients taking NOACs within 7 days of acute ischemic stroke. Although the authors paired GWTG-Stroke registry data with data from the ARAMIS registry, the time of last NOAC dose was known in only 2% of patients in this study. Moreover, patients taking NOACs within 48 hours of intravenous alteplase experienced a higher rate of symptomatic intracranial hemorrhage compared with the overall NOAC population (8% vs 3.7%), suggesting that alteplase should be avoided within 48 hours of NOAC administration until more comprehensive data are available. A re...
Source: JAMA - June 21, 2022 Category: General Medicine Source Type: research
Correlation Between Blood Glucose Variability and Early Therapeutic Effects After Intravenous Thrombolysis With Alteplase and Levels of Serum Inflammatory Factors in Patients With Acute Ischemic Stroke
ConclusionsBlood glucose variability is correlated with early neurological improvement after intravenous thrombolysis with alteplase in AIS patients. With the increase of blood glucose fluctuation range, the inflammatory response is enhanced, which affects the prognosis of patients.
Source: Frontiers in Neurology - February 22, 2022 Category: Neurology Source Type: research
Effectiveness of Standard-Dose vs. Low-Dose Alteplase for Acute Ischemic Stroke Within 3 –4.5 h
ConclusionIn the 34.5-h time window, the effectiveness and safety of standard-dose and low-dose alteplase may be comparable. A standard dose may be selected for patients with cardioembolism, atrial fibrillation, or hypercholesterolemia.
Source: Frontiers in Neurology - February 8, 2022 Category: Neurology Source Type: research
Experiences With Intravenous Thrombolysis in Acute Ischemic Stroke by Elderly Patients –A “Real World Scenario”
Conclusion: Although, the outcomes were less favorable in patients over 80 years of age, our results support the feasibility of using intravenous thrombolysis among patients over 80 years of age.
Source: Frontiers in Neurology - September 13, 2021 Category: Neurology Source Type: research
LB-004 Intravenous alteplase has different effects on the efficacy of aspiration and stent retriever thrombectomy: analysis of the COMPASS trial
ConclusionsPrior administration of IV Alteplase is not associated with improved procedural or clinical outcomes in patients with anterior circulation ELVO treated with MT. Alteplase may adversely affect the efficacy of aspiration first approach, but does not seem to influence the stent retriever first approach to MT.DisclosuresM. Mokin: 1; C; NIH R21NS109575. 2; C; Cerenovus, Medtronic. 4; C; Brain Q, Endostream Serenity medical, Synchron. M. Waqas: None. J. Fifi: 2; C; Stryker, Penumbra, Microvention. 4; C; Cerebrotech, The Stroke Project. R. De Leacy: 2; C; Penumbra, Cerenovus, Siemens, Imperative Care. 4; C; Synchron, E...
Source: Journal of NeuroInterventional Surgery - July 29, 2021 Category: Neurosurgery Authors: Mokin, M., Waqas, M., Fifi, J., De Leacy, R., Fiorella, D., Levy, E., Snyder, K., Hanel, R., Woodward, K., Chaudry, I., Rai, A., Frei, D., Delgado Almandoz, J., Kelly, M., Arthur, A., Baxter, B., English, J., Linfante, I., Fargen, K., Turk, A., Mocco, J., Tags: Late-breaking oral abstracts Source Type: research
Disparities between Asian and Non-Asian Thrombolyzed Acute Ischemic Stroke Patients in the Enhanced Control of Hypertension and Thrombolysis Stroke Trial
Conclusions: Within the context of an international clinical trial of thrombolyzed AIS patients, demography, risk factors, management, and odds of early neurological deterioration and ICH, all differ between Asian and non-Asian participants. However, patterns of functional recovery are similar between these major regional groups.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 21, 2021 Category: Neurology Source Type: research
Clinical Characteristics and Outcome of Patients With Hemorrhagic Transformation After Intravenous Thrombolysis in the WAKE-UP Trial
Conclusion: Our results indicate that HI is associated with stroke severity, cardiovascular risk factors and thrombolysis. PH is a rare complication, more frequent in severe stroke and with thrombolysis. In contrast to HI, PH is associated with worse functional outcome. The impact of HT after MRI-guided intravenous alteplase for unknown onset stroke on clinical outcome is similar as in the trials of stroke thrombolysis within a known early time-window.
Source: Frontiers in Neurology - August 27, 2020 Category: Neurology Source Type: research
Sex-related differences among ischaemic stroke patients treated with intravenous thrombolysis in Poland.
CONCLUSIONS: Of the ischaemic stroke patients treated with intravenous thrombolysis, women had worse long-term outcomes than men. This discrepancy may be explained by the older age and higher proportion of cardio-embolic strokes with more severe baseline deficits. However, multiple logistic analysis did not show that sex itself had an impact on the greater mortality in women after a stroke, or on the poorer prognosis.
PMID: 32469076 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - May 28, 2020 Category: Neurology Authors: Wiszniewska M, Fryze W, Wiśniewska A, Karliński M, Sobolewski P, Krzykowski G, Członkowska A Tags: Neurol Neurochir Pol Source Type: research
Infections causing stroke or stroke-like syndromes
ConclusionsStroke or stroke-like syndrome of infectious origin can be observed in an important proportion of case presenting with sensory-motor deficit of unknown origin; their accurate diagnosis has a considerable impact in terms of treatment choices and outcome.
Source: Infection - March 31, 2020 Category: Infectious Diseases Source Type: research
