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Noninvasive In Vivo Thrombus Imaging in Patients With Ischemic Stroke or Transient Ischemic Attack
CONCLUSIONS: 18F-GP1 positron emission tomography and computed tomography angiography is a novel noninvasive method of identifying in vivo cerebrovascular thrombosis, which holds major promise in understanding the role and origin of thrombosis in stroke.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT03943966.PMID:37439259 | DOI:10.1161/ATVBAHA.122.318204
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 13, 2023 Category: Cardiology Authors: Beth Whittington Evangelos Tzolos Rong Bing Jack Andrews Christophe Lucatelli Mark G MacAskill Adriana A S Tavares Tim Clark Nicholas L Mills Jennifer Nash Damini Dey Piotr J Slomka Norman Koglin Andrew W Stephens Edwin J R van Beek Colin Smith Marc R Dwe Source Type: research

Subclinical Vascular Composites Predict Clinical Cardiovascular Disease, Stroke, and Dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
CONCLUSIONS: Subclinical vascular composites of arteriosclerosis and atherosclerosis may be useful biomarkers to inform the vascular pathways contributing to events of CVD, CHD, stroke, and dementia.PMID:37205504 | PMC:PMC10187443 | DOI:10.1101/2023.05.01.23289364
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Timothy M Hughes Jordan Tanley Haiying Chen Christopher L Schaich Joseph Yeboah Mark A Espeland Joao A C Lima Bharath Ambale-Venkatesh Erin D Michos Jingzhong Ding Kathleen Hayden Ramon Casanova Suzanne Craft Stephen R Rapp Jos é A Luchsinger Annette L F Source Type: research

Relation of MRI Aortic Wall Area and Plaque to Incident Cardiovascular Events: The Framingham Heart Study
Conclusion In middle-aged community-dwelling adults, thoracic aortic wall area (AWA), plaque prevalence, and plaque volumes measured with MRI were independently associated with incident cardiovascular disease, with AWA associated in particular with stroke, and plaque associated with coronary heart disease. Clinical trial registration no. NCT00041418 © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Peshock in this issue.PMID:35638924 | DOI:10.1148/radiol.210830
Source: Atherosclerosis - May 31, 2022 Category: Cardiology Authors: Ulf Neisius Philimon N Gona Noriko Oyama-Manabe Michael L Chuang Christopher J O'Donnell Warren J Manning Connie W Tsao Source Type: research

Thrombus Structural Composition in Cardiovascular Disease
Arterioscler Thromb Vasc Biol. 2021 Jul 15:ATVBAHA120315754. doi: 10.1161/ATVBAHA.120.315754. Online ahead of print.ABSTRACTThrombosis is a major complication of cardiovascular disease, leading to myocardial infarction, acute ischemic stroke (AIS), or venous thromboembolism. Thrombosis occurs when a thrombus forms inside blood vessels disrupting blood flow. Developments in thrombectomy to remove thrombi from vessels have provided new opportunities to study thrombus composition which may help to understand mechanisms of disease and underpin improvements in treatments. We aimed to review thrombus compositions, roles of compo...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 15, 2021 Category: Cardiology Authors: Ghadir Alkarithi C édric Duval Yu Shi Fraser L Macrae Robert A S Ari ëns Source Type: research

Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease
Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. Introduction Atherosclerosis is a systemic vascular process that is considered a major cause of cerebrovascular and cardiovascular di...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

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