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Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
Crit Rev Food Sci Nutr. 2022 Jun 16:1-66. doi: 10.1080/10408398.2022.2084600. Online ahead of print.ABSTRACTAge-related diseases are associated with increased morbidity in the past few decades and the cost associated with the treatment of these age-related diseases exerts a substantial impact on social and health care expenditure. Anti-aging strategies aim to mitigate, delay and reverse aging-associated diseases, thereby improving quality of life and reducing the burden of age-related pathologies. The natural dietary antioxidant supplementation offers substantial pharmacological and therapeutic effects against various dise...
Source: Atherosclerosis - June 16, 2022 Category: Cardiology Authors: Phaniendra Alugoju V K D Krishna Swamy Naga Venkata Anusha Anthikapalli Tewin Tencomnao Source Type: research

Janssen Demonstrates Commitment to Advancing Science and Innovation in the Treatment of Solid Tumors at ESMO Annual Congress
September 8, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than ten data presentations from its lung cancer, bladder cancer and prostate cancer portfolio and pipeline will be featured during the European Society for Medical Oncology (ESMO) Annual Congress 2021 virtual meeting, September 16–21. Further details about these data and the science Janssen is advancing will be made available throughout ESMO via the Janssen Oncology Virtual Newsroom.“With a diverse oncology portfolio and pipeline spanning bladder cancer, lung cancer and prostate cancer, Janssen...
Source: Johnson and Johnson - September 8, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

A prospective study of health conditions related to alcohol consumption cessation among 97,852 drinkers aged 45 and over in Australia.
CONCLUSIONS: Diagnosis with a variety of health conditions appears to prompt drinking cessation in older adults. This article is protected by copyright. All rights reserved. PMID: 30758044 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - February 13, 2019 Category: Addiction Authors: Sarich P, Canfell K, Banks E, Paige E, Egger S, Joshy G, Korda R, Weber M Tags: Alcohol Clin Exp Res Source Type: research

Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: Implications for epidemiological research
Conclusions A variety of sociodemographic, lifestyle and health-related characteristics are associated with PSA testing, suggesting that observed associations of some of these traits with risk for prostate cancer in epidemiological studies may be, at least partially, due to detection bias.
Source: Cancer Epidemiology - September 29, 2016 Category: Cancer & Oncology Source Type: research

The Variation with Age of 67 Macro- and Microelement Contents in Nonhyperplastic Prostate Glands of Adult and Elderly Males Investigated by Nuclear Analytical and Related Methods.
Abstract To clarify age-related changes of 67 macro- and microelement contents in prostate gland of adult and geriatric males, a quantitative measurement by five analytical methods was performed. The nonhyperplastic prostate glands of 65 subjects (European-Caucasian aged 21-87 years) were investigated by energy dispersive X-ray fluorescence (EDXRF), instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides (INAA-SLR), instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides (INAA-LLR), inductively coupled plasma atomic emi...
Source: Biological Trace Element Research - May 5, 2015 Category: Biology Authors: Zaichick V Tags: Biol Trace Elem Res Source Type: research

Fit middle-aged men have lower cancer risk
Conclusion This study shows that cardiovascular fitness is likely to reduce men's chances of developing lung and colorectal cancer, and appears to boost survival from cancer or cardiovascular disease in those diagnosed after the age of 65. This was based on comparing the top 40% of fittest men with the 20% least fit. The study focused on fitness and took account of major risk factors for cancer, such as smoking and blood pressure. However, it left out one important risk factor: diet. What people eat and drink is known to affect cancer risk. The fittest group may also have been the healthiest in terms of eating well and ...
Source: NHS News Feed - March 27, 2015 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news

Smoking Causes More Kinds Of Deaths Than We Ever Thought
Breast cancer, prostate cancer, and even routine infections. A new report ties these and other maladies to smoking and says an additional 60,000 to 120,000 deaths each year in the United States are probably due to tobacco use. The study by the American Cancer Society and several universities, published in Thursday's New England Journal of Medicine, looks beyond lung cancer, heart disease and other conditions already tied to smoking, and the 480,000 U.S. deaths attributed to them each year. "Smokers die, on average, more than a decade before nonsmokers," and in the U.S., smoking accounts for one of every five deaths, Dr. ...
Source: Science - The Huffington Post - February 12, 2015 Category: Science Source Type: news

Exercise may cut breast cancer risk, study finds
ConclusionThis large study has shown that increased exercise is associated with a reduced risk of breast cancer for postmenopausal women. Strengths of the study include the large number of women and that self-reports of breast cancer were verified by a pathology report in 94% of cases.However, as the authors point out, a limitation of this study is that it was conducted on a group of teachers who were mainly of a healthy weight. This means the results may not be applicable to women of a different weight with different occupations, including more or less sedentary jobs.The study also relied on self-reported exercise levels,...
Source: NHS News Feed - August 11, 2014 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news

Cycling linked to prostate cancer, but not infertility
Conclusion This study has looked at the associations between the number of hours spent cycling a week and erectile dysfunction, infertility and prostate cancer in men over the age of 50 who cycle regularly. It found no association between the time spent cycling and erectile dysfunction or infertility, but did find a dose-response association with prostate cancer for men over the age of 50, with risk increasing as the time a week spent cycling increased. As the researchers point out, this type of study cannot prove causality (that increased cycling time leads to prostate cancer), only an association. Different study desig...
Source: NHS News Feed - July 9, 2014 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news

Adiponectin as a routine clinical biomarker.
Abstract Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; <4 μg/mL) are associated with a variety of diseases, including dysmetabolism (type 2 diabetes, insulin resistance, hypertension, dyslipidemia, metabolic syndrome, hyperuricemia), atherosclerosis (coronary artery disease, stroke, peripheral artery disease), slee...
Source: Clin Med Res - January 1, 2014 Category: Research Authors: Kishida K, Funahashi T, Shimomura I Tags: Best Pract Res Clin Endocrinol Metab Source Type: research