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Identification, characterization, and engineering of glycosylation in thrombolyticsa
Biotechnol Adv. 2023 May 12:108174. doi: 10.1016/j.biotechadv.2023.108174. Online ahead of print.ABSTRACTCardiovascular diseases, such as myocardial infarction, ischemic stroke, and pulmonary embolism, are the most common causes of disability and death worldwide. Blood clot hydrolysis by thrombolytic enzymes and thrombectomy are key clinical interventions. The most widely used thrombolytic enzyme is alteplase, which has been used in clinical practice since 1986. Another clinically used thrombolytic protein is tenecteplase, which has modified epitopes and engineered glycosylation sites, suggesting that carbohydrate modifica...
Source: Adv Data - May 14, 2023 Category: Epidemiology Authors: Martin Toul Veronika Slonkova Jan Mican Adam Urminsky Maria Tomkova Erik Sedlak David Bednar Jiri Damborsky Lenka Hernychova Zbynek Prokop Source Type: research

Predictive Value of Pediatric Stroke Diagnoses in Administrative Data: A Systematic Literature Review
Conclusion Caution is recommended in the use and interpretation of non-validated administrative data for pediatric stroke. Data on the PPV and sensitivity of pediatric stroke diagnoses in administrative data remain limited and are only available from high-income countri es.
Source: Neuroepidemiology - November 1, 2022 Category: Epidemiology Source Type: research

Thromboembolic events, bleeding, and mortality in patients with cerebral venous thrombosis: a nationwide cohort study
We examined the clinical course of patients with CVT overall and according to age and sex. Using Danish registries, we identified all patients with a first-time primary inpatient diagnosis of CVT from 1996 to 2018 (N = 653, median age 41 years, 67% women) and individuals from the general population, matched on age, sex, and calendar year (N = 65,300). Patients with CVT were at increased risk of venous thromboembolism (VTE) in other sites, ischemic stroke, major bleeding, and mortality. For both sexes, the increased risks of VTE in other sites were most prominent among the young (18-54 years), while the increased risks of i...
Source: Adv Data - September 16, 2022 Category: Epidemiology Authors: Nils Skajaa Jan Vandenbroucke Claus Ziegler Simonsen Henrik Toft Toft S ørensen Kasper Adelborg Source Type: research

Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study
AbstractThe present study aimed to determine the associations between insomnia and cardiovascular diseases (CVDs) using Mendelian randomisation (MR) analysis. As instrumental variables, we used 208 independent single-nucleotide polymorphisms associated with insomnia at the genome-wide significance threshold in a meta-analysis of genome-wide association studies in the UK Biobank and 23andMe including a total of 397  959 self-reported insomnia cases and 933 057 non-cases. Summary-level data for nine CVDs were obtained from the UK Biobank including 367 586 individuals of European ancestry. After correction for multiple tes...
Source: European Journal of Epidemiology - March 12, 2021 Category: Epidemiology Source Type: research

Using the Case-Crossover Design to Assess Short-Term Risks of Bleeding and Arterial Thromboembolism After Switching Between Oral Anticoagulants in a Population-Based Cohort of Patients With Atrial Fibrillation
AbstractUsing nationwide Danish registries, we conducted a population-based case-crossover study evaluating the association between switching from a vitamin K antagonist (VKA) to a direct oral anticoagulant (DOAC), and vice versa, and 30-day risks of bleeding and arterial thromboembolism in patients with atrial fibrillation (AF). The case-crossover population was identified among oral anticoagulant users during 2011 –2018 (n = 123,217) as patients with AF with 1) a case-defining outcome and 2) an anticoagulant switch during the 180 days preceding the outcome. Odds ratios were estimated using conditional logistic regres...
Source: American Journal of Epidemiology - July 8, 2020 Category: Epidemiology Source Type: research

Using the Case-crossover Design to Assess Short-term Risks of Bleeding and Arterial Thromboembolism Following Switching Between Oral Anticoagulants in a Population-based Cohort of Atrial Fibrillation Patients.
Abstract Using nationwide Danish registries, we conducted a population-based case-crossover study evaluating the association between switching from a vitamin K antagonist (VKA) to a direct oral anticoagulant (DOAC), and vice-versa, and 30-day risks of bleeding and arterial thromboembolism in atrial fibrillation (AF) patients. The case-crossover population was identified among oral anticoagulant users during 2011-2018 (n = 123,217), as AF patients with (a) a case-defining outcome and (b) an anticoagulant switch during the 180 days preceding the outcome. Odds Ratios were estimated using conditional logistic regres...
Source: Am J Epidemiol - July 7, 2020 Category: Epidemiology Authors: Hellfritzsch M, Wang SV, Grove EL, Gagne JJ, Hallas J, Pottegård A Tags: Am J Epidemiol Source Type: research

Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels
ABSTRACT Tissue factor pathway inhibitor (TFPI) regulates the formation of intravascular blood clots, which manifest clinically as ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). TFPI plasma levels are heritable, but the genetics underlying TFPI plasma level variability are poorly understood. Herein we report the first genome‐wide association scan (GWAS) of TFPI plasma levels, conducted in 251 individuals from five extended French‐Canadian Families ascertained on VTE. To improve discovery, we also applied a hypothesis‐driven (HD) GWAS approach that prioritized single nucleotide polymorphism...
Source: Genetic Epidemiology - April 19, 2017 Category: Epidemiology Authors: Jessica Dennis, Alejandra Medina ‐Rivera, Vinh Truong, Lina Antounians, Nora Zwingerman, Giovana Carrasco, Lisa Strug, Phil Wells, David‐Alexandre Trégouët, Pierre‐Emmanuel Morange, Michael D. Wilson, France Gagnon Tags: RESEARCH ARTICLE Source Type: research

Return to Paid Work after Ischemic Stroke in Patients Treated with Intravenous Thrombolysis
Conclusion: IVT treatment was a positive predictor of returning to full-time work after stroke.Neuroepidemiology 2016;46:114-117
Source: Neuroepidemiology - January 20, 2016 Category: Epidemiology Source Type: research

Mediators of First- Versus Second-generation Antipsychotic-related Mortality in Older Adults
Conclusions: Acute cardiovascular events and pneumonia may explain part of the mortality difference between first- and second-generation antipsychotic initiators in this analysis.
Source: Epidemiology - August 6, 2015 Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research