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Specialty: Drugs & Pharmacology
Condition: Thrombosis
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Total 546 results found since Jan 2013.
Utilization of triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention
ConclusionsThe utilization of TAT following PCI among high-stroke risk AF patients steadily increased from 2011 to 2020, reaching 65.4% by the end of the study period. However, in 2020, a significant proportion of 29.4% of patients still received DAPT, indicating that many AF patients undergoing PCI did not receive adequate antithrombotic therapy.
Source: European Journal of Clinical Pharmacology - February 24, 2023 Category: Drugs & Pharmacology Source Type: research
Discovery and development of Factor Xa inhibitors (2015 –2022)
This article summarizes the small molecule Factor Xainhibitors developed from 2015 to 2022, classifies them according to their scaffolds, focuses on the analysis of their structure-activity relationships, and provides a brief assessment of them.
Source: Frontiers in Pharmacology - February 21, 2023 Category: Drugs & Pharmacology Source Type: research
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO
CNS Neurol Disord Drug Targets. 2023 Feb 3. doi: 10.2174/1871527322666230203140805. Online ahead of print.ABSTRACTThe gut microbiome interacts with the brain bidirectionally through the microbiome-gut-brain axis, which plays a key role in regulating various nervous system pathophysiological processes. Trimethylamine N-oxide (TMAO) is produced by choline metabolism through intestinal microorganisms, which can cross the blood-brain barrier to act on the central nervous system. Previous studies have shown that elevated plasma TMAO concentrations increase the risk of major adverse cardiovascular events, but there are few studi...
Source: CNS and Neurological Disorders Drug Targets - February 6, 2023 Category: Drugs & Pharmacology Authors: Ruxin Tu Jian Xia Source Type: research
QiShen YiQi and its components attenuate acute thromboembolic stroke and carotid thrombosis by inhibition of CD62P/PSGL-1-mediated platelet-leukocyte aggregate formation
CONCLUSION: QSYQ and YQ/HX components attenuated thromboembolic stroke and carotid thrombosis by decreasing PLA formation via inhibiting CD62P/PSGL-1 expressions. This study shed a new light on the prevention of thromboembolic stroke.PMID:36738500 | DOI:10.1016/j.biopha.2023.114323
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 4, 2023 Category: Drugs & Pharmacology Authors: Mingxing Yu Guangxu Xiao Linhong Han Li Peng Huanyi Wang Shuang He Ming Lyu Yan Zhu Source Type: research
An undefined cystatin CsCPI1 from tea plant Camellia sinensis harbors antithrombotic activity
Biomed Pharmacother. 2023 Jan 25;159:114285. doi: 10.1016/j.biopha.2023.114285. Online ahead of print.ABSTRACTTea consumption has been linked to a decreased risk of cardiovascular disease (CVD) mortality, which imposes a heavy burden on the healthcare system; however, which components in tea cause this beneficial effect is not fully understood. Here we uncovered a cystatin (namely CsCPI1), which is a cysteine proteinase inhibitor (CPI) of the tea plant (Camellia sinensis) that promotes antithrombotic activity. Since thrombosis is a common pathogenesis of fatal CVDs, we investigated the effects of CsCPI1, which showed good ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 27, 2023 Category: Drugs & Pharmacology Authors: Mingqian Fang Jong-Ho Cha Hao-Ching Wang Peng Ye Bi Chen Mengrou Chen Wen-Hao Yang Xiuwen Yan Source Type: research
Network pharmacology and experimental study of phenolic acids in salvia miltiorrhiza bung in preventing ischemic stroke
At present, the preventive effect of ischemic stroke is not ideal, and the preventive drugs are limited. Danshen, the dried root of Salvia miltiorrhiza Bge, is a common medicinal herb in Traditional Chinese Medicine, which has been used for the treatment of cardiovascular diseases for many years. Phenolic Acids extracted from danshen, which showed multiple biological activities, have been developed as an injection for the treatment of ischemic stroke. However, its preventive effect on ischemic stroke has not been fully reported. The current study aimed to identify the potential active phenolic acids for the prevention of i...
Source: Frontiers in Pharmacology - January 27, 2023 Category: Drugs & Pharmacology Source Type: research
Conversion From Intravenous Alteplase to Tenecteplase for Treatment of Acute Ischemic Stroke Across a Large Community Hospital Health System
CONCLUSION AND RELEVANCE: Conversion from alteplase to tenecteplase can be safely and effectively achieved at a large community hospital health system with differing levels of stroke certification. There were also additional cost savings and practical advantages including workflow benefits.PMID:36688289 | DOI:10.1177/10600280221149409
Source: The Annals of Pharmacotherapy - January 23, 2023 Category: Drugs & Pharmacology Authors: Erika Dittmar Thomas Wolfel Lourdes Menendez Jessilyn Pozo Maygret Ramirez Starlie C Belnap Felipe De Los Rios La Rosa Source Type: research
