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Specialty: Drugs & Pharmacology
Condition: Thrombosis
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Total 546 results found since Jan 2013.
Impact of the ABCD-GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi-site, Real-world Investigation
The objective of this study was to validate the ability of ABCD-GENE score to predict risk for atherothrombotic events in a diverse, real-world population of clopidogrel-treated PCI patients who received clinical CYP2C19 genotyping to guide antiplatelet therapy. A total of 2341 adult patients who underwent PCI, were genotyped for CYP2C19, and received treatment with clopidogrel across four institutions were included (mean age 64±12 years, 35% female, 20% Black). The primary outcome was major atherothrombotic events, defined as the composite of all-cause death, myocardial infarction, ischemic stroke, stent thrombosis, or r...
Source: Clinical Pharmacology and Therapeutics - April 16, 2022 Category: Drugs & Pharmacology Authors: Cameron D Thomas Francesco Franchi Ellen C Keeley Joseph S Rossi Marshall Winget R David Anderson Alyssa L Dempsey Yan Gong Megan N Gower Richard A Kerensky Natasha Kulick Jean G Malave Caitrin W McDonough Ian R Mulrenin Petr Starostik Amber L Beitelshees Source Type: research
Direct oral anticoagulants compared with vitamin K antagonists for left ventricular thrombus: a systematic review and meta-analysis
CONCLUSION: DOACs and VKAs showed no difference in the safety and efficacy of patients with LVT. DOACs might be superior to VKAs for LVT treatment in post-AMI patients.PMID:35400334 | DOI:10.2174/1381612828666220408120832
Source: Current Pharmaceutical Design - April 11, 2022 Category: Drugs & Pharmacology Authors: Shu Fang Bao-Zhen Zhu Fan Yang Zhe Wang Qian Xiang Yan-Jun Gong Source Type: research
The Efficacy and Safety of Ginkgo Terpene Lactone Preparations in the Treatment of Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Conclusion: Ginkgo terpene lactone preparations have good therapeutic effects on patients with IS. For acute IS, ginkgo diterpene lactone meglumine injection can be used as a complementary therapy to improve the clinical efficacy of rt-PA.
Source: Frontiers in Pharmacology - March 18, 2022 Category: Drugs & Pharmacology Source Type: research
Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review
Conclusions Looking at the big picture, the use of genetic dosing for warfarin initiation can lead to better outcomes. Whether these better outcomes are clinically or economically beneficial remains controversial.
Source: International Journal of Clinical Pharmacy - March 5, 2022 Category: Drugs & Pharmacology Source Type: research
Effect Modification by Indication to the Risks of Major Thromboembolic Adverse Events in Patients Receiving Intravitreal Anti-Vascular Endothelial Growth Factor Treatment: A Population-Based Retrospective Cohort Study
ConclusionsPatients treated with aflibercept or ranibizumab for different indications may be associated with varying risk of TAEs. The findings provide evidence to support treatment selection, taking indications and TAE risk into consideration.
Source: BioDrugs - March 1, 2022 Category: Drugs & Pharmacology Source Type: research
Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3 β/β-catenin signaling pathway
Acta Pharmacol Sin. 2022 Feb 25. doi: 10.1038/s41401-021-00844-9. Online ahead of print.ABSTRACTStroke is the major cause of death and disability worldwide. Most stroke patients who survive in the acute phase of ischemia display various extents of neurological deficits. In order to improve the prognosis of ischemic stroke, promoting endogenous neurogenesis has attracted great attention. Salvianolic acid A (SAA) has shown neuroprotective effects against ischemic diseases. In the present study, we investigated the neurogenesis effects of SAA in ischemic stroke rats, and explored the underlying mechanisms. An autologous throm...
Source: Acta Pharmacologica Sinica - February 26, 2022 Category: Drugs & Pharmacology Authors: Sen Zhang De-Wen Kong Guo-Dong Ma Cheng-di Liu Yu-Jiao Yang Shan Liu Nan Jiang Zi-Rong Pan Wen Zhang Ling-Lei Kong Guan-Hua Du Source Type: research
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)
Biomed Pharmacother. 2022 Feb 14;148:112718. doi: 10.1016/j.biopha.2022.112718. Online ahead of print.ABSTRACTMyocardial infarction and stroke are the leading causes of death in the world. Numerous evidence has confirmed that hypertension promotes thrombosis and induces myocardial infarction and stroke. Recent findings reveal that neutrophil extracellular traps (NETs) are involved in the induction of myocardial infarction and stroke. Meanwhile, patients with severe COVID-19 suffer from complications such as myocardial infarction and stroke with pathological signs of NETs. Due to the extremely low amount of virus detected i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 17, 2022 Category: Drugs & Pharmacology Authors: Qingguang Zhang Shang Ling Kaili Hu Jun Liu Jin-Wen Xu Source Type: research
A practice game changer: Impact of tenecteplase for acute ischemic stroke in a multicenter quality improvement project
CONCLUSION: Institutions can safely transition from alteplase to tenecteplase as a thrombolytic of choice for AIS.PMID:35037028 | DOI:10.1093/ajhp/zxab482
Source: American Journal of Health-System Pharmacy : AJHP - January 17, 2022 Category: Drugs & Pharmacology Authors: Lydia Noh Felix Pham Lara Haddad Theresa Burkhard Laurie Paletz Marco Pech Maya Lewis Vicki Manoukian Konrad H Schlick Shlee Song Source Type: research
