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Condition: Thrombosis
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Total 840 results found since Jan 2013.

HRT increases ovarian cancer risk by small amount
Conclusion This systematic review and meta-analysis showed that ovarian cancer risk was significantly increased in current HRT users, even in those with less than five years of HRT use (the average was three years). In ex-users, risks decreased the longer ago HRT use had stopped, but risks during the first few years after stopping remained significant. Furthermore, about a decade after stopping, long-duration hormone therapy use (average nine years of HRT use), there still seemed to be a small excess risk. The review has a few limitations, however. The main one is that the review was heavily influenced by just two of t...
Source: NHS News Feed - February 13, 2015 Category: Consumer Health News Tags: Cancer Medication Older people Source Type: news

Pharmacogenomics of antiplatelet drugs.
Authors: Sabatine MS, Mega JL Abstract Clopidogrel, a platelet P2Y12 inhibitor, is one of the most widely prescribed drugs in cardiovascular medicine because it reduces ischemic and thrombotic complications. It is a prodrug requiring biotransformation into the active metabolite by the hepatic cytochrome 450 system, especially the CYP2C19 enzyme. Candidate gene studies and genome-wide association studies have identified loss-of-function CYP2C19 variants to be associated with a diminished pharmacologic response. Specifically, compared with noncarriers, carriers of at least one copy of a loss-of-function CYP2C19 allel...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Monitoring target-specific oral anticoagulants.
Authors: Konkle BA Abstract Target-specific oral anticoagulants are approved for use for the prevention of stroke in atrial fibrillation and for the prevention and treatment of venous thrombosis without the need for laboratory monitoring. However, there are clinical settings in which laboratory measurement of anticoagulant effect is needed. These may include patients with life-threatening bleeding or those requiring emergency surgery, in the setting of renal or hepatic failure, or patients with thrombosis on therapy. This chapter reviews the use of laboratory testing to assess the anticoagulant effect of these drug...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Future prospects for contact factors as therapeutic targets.
Authors: Gailani D Abstract Anticoagulants currently used in clinical practice to treat or prevent thromboembolic disease are effective, but place patients at increased risk for serious bleeding because they interfere with plasma enzymes (thrombin and factor Xa) that are essential for hemostasis. In the past 10 years, work with genetically altered mice and studies in baboons and rabbits have demonstrated that the plasma contact proteases factor XI, factor XII, and prekallikrein contribute to the formation of occlusive thrombi despite having limited roles in hemostasis. In the case of factor XI, epidemiologic data f...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

American Heart Association's Life's Simple 7 and Risk of Venous Thromboembolism: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study Epidemiology
Conclusions Life's Simple 7, a CVH metric, was associated with reduced VTE risk. Findings suggest that efforts to improve the population's CVH may reduce VTE incidence.
Source: JAHA:Journal of the American Heart Association - February 27, 2015 Category: Cardiology Authors: Olson, N. C., Cushman, M., Judd, S. E., McClure, L. A., Lakoski, S. G., Folsom, A. R., Safford, M. M., Zakai, N. A. Tags: Epidemiology Source Type: research

CE: Atrial Fibrillation: Updated Management Guidelines and Nursing Implications
This article reviews the recently updated guideline for the management of atrial fibrillation, issued jointly by the American Heart Association, the American College of Cardiology, and the Heart Rhythm Society. It focuses on the prevention of thromboembolism and on symptom control, and stresses the importance of patient adherence to treatment plans in order to ensure better outcomes.
Source: AJN - April 24, 2015 Category: Nursing Tags: Feature Articles Source Type: research

Abstract 323: Standardized Triggers for Catheterization Laboratory Morbidity and Mortality Case Review Session Title: Poster Session III
Conclusions: We present a 10-year experience with the use of objective triggers to identify cases for M&M review. This method identifies challenging cases of educational value and could be immediately implemented to strengthen national catheterization laboratory quality improvement programs.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Doll, J. A., Patel, M. R., Sketch, M. H., Harrison, J. K., Tcheng, J. E. Tags: Session Title: Poster Session III Source Type: research

Implementation of non-vitamin K antagonist oral anticoagulants in daily practice: the need for comprehensive education for professionals and patients
Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used for the prevention and treatment of venous thromboembolism and for stroke prevention in patients with atrial fibrillation. NOACs do not require routine coagulation monitoring, creating a challenge to established systems for patient follow-up based on regular blood tests. Healthcare professionals (HCPs) are required to cope with a mixture of patients receiving either a vitamin K antagonist or a NOAC for the same indications, and both professionals and patients require education about the newer drugs. A European working group convened to consider the ...
Source: Thrombosis Journal - May 26, 2015 Category: Hematology Authors: Hein HeidbuchelDana BertiManuel CamposLien DestegheAna FreixoAntónio NunesVanessa RoldánVincenzo ToschiRiitta Lassila Source Type: research

Combined oral contraceptives and risk of venous thromboembolism: there is higher risk in new generations compared to second generations, but paradoxically not in norgestimate-containing-pills
This study examines the VTE risk associated with COC use in two large UK databases. Methods...
Source: Evidence-Based Medicine - September 24, 2015 Category: Internal Medicine Authors: Plu-Bureau, G. Tags: Smoking and tobacco, Epidemiologic studies, General practice / family medicine, Drugs: cardiovascular system, Stroke, Contraception, Drugs: obstetrics and gynaecology, Family planning, Alcohol, Health education, Smoking Aetiology/Harm Source Type: research

Mechanical circulatory support: balancing bleeding and clotting in high-risk patients.
Authors: Baumann Kreuziger L, Massicotte MP Abstract Mechanical circulatory support (MCS) provides a bridge to heart transplant in children and adults with life-threatening heart failure and sustains patients ineligible for transplant. Extracorporeal membrane oxygenation (ECMO) provides temporary support for patients in cardiac or pulmonary failure through external gas exchange and continuous flow of blood. Because the median time to heart transplant exceeds event-free time on ECMO, pulsatile left ventricular assist devices (LVADs) are used to support infants and children. Continuous flow LVADs are preferred in ado...
Source: Hematology ASH Education Program - December 10, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Long-term outcome after cerebral venous thrombosis: analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients
Abstract Cerebral venous thrombosis (CVT) affects mainly working-aged individuals. Functional recovery after CVT is generally considered good with about 3/4 of patients achieving short-term independence. However, vascular events, long-term functional outcome, and employment after CVT remain poorly investigated. We identified consecutive adult CVT patients treated at the Helsinki University Hospital (1987–2013) and invited them to a follow-up visit. Each clinical examination was combined with interview. We also recorded recurrent venous thromboembolism (VTE) and hemorrhagic events during follow-up and antithrombo...
Source: Journal of Neurology - January 2, 2016 Category: Neurology Source Type: research

Answers to Epilogue questions
AnswersQuestion 1: C Unenhanced CT examination of the brain revealed extensive thrombosis in the superior sagittal, straight and left transverse sinuses (figure 1). The CT angiogram (figure 2) confirmed venous thrombosis and an arterial infarct. It revealed complete occlusion of left internal carotid artery and segmental vasculopathy, affecting multiple intracranial and extracranial vessels of both the anterior and posterior circulation along with an aneurysmal ascending aorta. The contrast-enhanced CT scan demonstrated a filling defect of the superior sagittal sinus with minimal peripheral contrast enhancement, known as t...
Source: Archives of Disease in Childhood - Education and Practice - May 17, 2016 Category: Pediatrics Authors: Mundada, V., Krishnakumar, D., Chitre, M., Das, T. Tags: Journalology, Eye Diseases, Stroke, Diet, Ophthalmology, Child and adolescent psychiatry (paedatrics), Radiology, Disability, Rheumatology, Dermatology, Clinical diagnostic tests, Radiology (diagnostics), Competing interests (ethics), Metabolic disorders Source Type: research

Dementia risk after spontaneous intracerebral haemorrhage: a prospective cohort study
Publication date: July 2016 Source:The Lancet Neurology, Volume 15, Issue 8 Author(s): Solène Moulin, Julien Labreuche, Stéphanie Bombois, Costanza Rossi, Gregoire Boulouis, Hilde Hénon, Alain Duhamel, Didier Leys, Charlotte Cordonnier Background Dementia occurs in at least 10% of patients within 1 year after stroke. However, the risk of dementia after spontaneous intracerebral haemorrhage that accounts for about 15% of all strokes has not been investigated in prospective studies. We aimed to determine the incidence of dementia and risk factors after an intracerebral haemorrhage. Methods We did a prospective...
Source: The Lancet Neurology - June 6, 2016 Category: Neurology Source Type: research

0417 : Thrombolisis with tenecteplase (metalyse) in myocardial infarction an always topical issue
Conclusion Thrombolysis by Tenecteplase of STEMI admitted to ICCU was successfull in 89% of cases, which proves its effectiveness compared with other thrombolytic agents. The reperfusion rate was inversely proportional to time limit chest pain – arrival at ER. Patient education to call the ambulance (190) in case of chest pain should improve this delay and increase the reperfusion rate. The author hereby declares no conflict of interest
Source: Archives of Cardiovascular Diseases Supplements - June 15, 2016 Category: Cardiology Source Type: research

The Fault in our (Three) Stars
Conclusions Like it or not (I think only a minority of CEOs will be happy with their star rating and many physicians will chafe at the ED metrics being used) CMS has started rating your hospital on a five star scale. All of the ED metrics used in the star rating system are typically followed by the ED medical director and nursing leaders, but now you may notice hospital administration is more interested in your performance. The good news is that with added visibility, hospital admin may provide more support in helping to improve performance. We need to know which of our metrics are involved and how we’re contributing to ...
Source: EPMonthly.com - September 27, 2016 Category: Emergency Medicine Authors: Matt McGahen Tags: Uncategorized Source Type: news