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Total 295 results found since Jan 2013.

What Are the Complications of Sickle Cell Trait?
Discussion Sickle cell disease (SCD) is a group of inherited blood disorders where there are abnormal hemoglobin molecules and the red blood cells take on a characteristic sickled shape instead of a rounded shape. Sickled hemoglobin provides an evolutionary advantage of giving the individual increased protection against severe and cerebral malaria. The sickled shape doesn’t move through the vascular system as well and therefore is more likely to aggregate in small vessels causing an increased risk of vaso-occlusive disease, acute chest syndrome, splenic sequestration, and priapism. There is also an increased risk of ...
Source: PediatricEducation.org - September 4, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Position statement from the Indian Society of Gastroenterology, Cardiological Society of India, Indian Academy of Neurology and Vascular Society of India on gastrointestinal bleeding and endoscopic procedures in patients on antiplatelet and/or anticoagulant therapy
AbstractAntiplatelet and/or anticoagulant agents (collectively known as antithrombotic agents) are used to reduce the risk of thromboembolic events in patients with conditions such as atrial fibrillation, acute coronary syndrome, recurrent stroke prevention, deep vein thrombosis, hypercoagulable states and endoprostheses. Antithrombotic-associated gastrointestinal (GI) bleeding is an increasing burden due to the growing population of advanced age with multiple comorbidities and the expanding indications for the use of antiplatelet agents and anticoagulants. GI bleeding in antithrombotic users is associated with an increase...
Source: Indian Journal of Gastroenterology - June 5, 2023 Category: Gastroenterology Source Type: research

COVID-19 Infected ST-Elevation Myocardial Infarction in INDIA (COSTA INDIA)
CONCLUSIONS: In this large registry of STEMI patients, we did not find significant excess in in-hospital mortality among COVID-19 co-infected patients compared with non-infected patients despite lower rate of primary PCI and reperfusion treatment, though composite of in-hospital mortality, re-infarction, stroke and heart failure was higher.PMID:37230465 | PMC:PMC10204278 | DOI:10.1016/j.ihj.2023.05.009
Source: Indian Heart J - May 25, 2023 Category: Cardiology Authors: Abdullakutty Jabir Geevar Zachariah Padinhare Purayil Mohanan Mohit Dayal Gupta Sivasubramanian Ramakrishnan Chandra Bhan Meena Sridhar L Meennahalli Palleda Girish Dipak Ranjan Das Anshul Gupta Praveen Nagula Tom Devasia Bhavesh Vajifdar None Kamlesh Tha Source Type: research

Biosimilar Tenecteplase Versus Alteplase in Acute Ischemic Stroke: A Real World Study
CONCLUSION: This present study observed no difference in the efficacy and safety between biosimilar TNK and rTPA. Our findings are in concordance with published trials showing equivalence between the two molecules.PMID:37034051 | PMC:PMC10081554 | DOI:10.4103/aian.aian_754_22
Source: Atherosclerosis - April 10, 2023 Category: Cardiology Authors: Ayush Mohan Snigdha Komakula Suhas Murali Pooja Anand Dyuti Shah V Y Vishnu Awadh Kishor Pandit Ayush Agarwal Deepti Vibha Mamta Bhushan Singh M V Padma Srivastava Rohit Bhatia Source Type: research

Biosimilar tenecteplase versus alteplase in acute ischemic stroke: A real world study
Conclusion: This present study observed no difference in the efficacy and safety between biosimilar TNK and rTPA. Our findings are in concordance with published trials showing equivalence between the two molecules.
Source: Annals of Indian Academy of Neurology - January 25, 2023 Category: Neurology Authors: Ayush Mohan Snigdha Komakula Suhas Murali Pooja Anand Dyuti Shah VY Vishnu Awadh Kishor Pandit Ayush Agarwal Deepti Vibha Mamta Bhushan Singh MV Padma Srivastava Rohit Bhatia Source Type: research

A case of ischemic stroke and transient thrombocytopenia in a young female following adenoviral vector-based COVID-19 vaccination: Was the association incidental or causal?
We report a 23-year-old healthy female who developed seizures, altered sensorium, and left hemiparesis, 20 days after receiving the first dose of adenoviral vector-based COVID-19 vaccine "Covishield™." The patient had transient thrombocytopenia. The D-dimer level was 2460 ng/mL. Magnetic resonance imaging (MRI) demonstrated occlusion of M2 segment of the middle cerebral artery and cerebral infarction. Platelet factor-4 antibodies level was normal. Treatment with aspirin and antiepileptic drugs resulted in a remarkable recovery. This is the first Indian case report of ischemic stroke and transient thrombocytopenia followi...
Source: Primary Care - January 9, 2023 Category: Primary Care Authors: Shweta Pandey Ravindra Kumar Garg Pooja Tripathi Hardeep S Malhotra Neeraj Kumar Source Type: research

Carotid Health in Patients with Cerebral Venous Thrombosis
CONCLUSION: This is the first study to our knowledge looking at carotid health in venous strokes. The relative risk for carotid atherosclerosis in CVT patients is higher and requires long-term follow-up for the initiation of preventive measures.PMID:36352596 | DOI:10.4103/0028-3886.359210
Source: Atherosclerosis - November 10, 2022 Category: Cardiology Authors: Naman M Shah Aralikatte Onkarappa Saroja Karkal Ravishankar Naik Pradeep S Goudar Source Type: research

Gut microbiota dysbiosis in patients with intracranial sino-venous thrombosis and acute ischemic stroke in the young
Varsha A Prabhu, Vinay Rajput, Rakeshkumar Yadav, Kushal Gohil, Mahesh S Dharne, Mazhuvancherry Kesavan Unnikrishnan, Sankar Prasad GorthiAnnals of Indian Academy of Neurology 2022 25(5):980-983
Source: Annals of Indian Academy of Neurology - October 31, 2022 Category: Neurology Authors: Varsha A Prabhu Vinay Rajput Rakeshkumar Yadav Kushal Gohil Mahesh S Dharne Mazhuvancherry Kesavan Unnikrishnan Sankar Prasad Gorthi Source Type: research

Carotid Health in Patients with Cerebral Venous Thrombosis
Conclusion: This is the first study to our knowledge looking at carotid health in venous strokes. The relative risk for carotid atherosclerosis in CVT patients is higher and requires long-term follow-up for the initiation of preventive measures.
Source: Neurology India - October 21, 2022 Category: Neurology Authors: Naman M Shah Aralikatte Onkarappa Saroja Karkal Ravishankar Naik Pradeep S Goudar Source Type: research

Sixteen-Syndrome in a Young Patient with Systemic Lupus Erythematosus
This report describes a case of 16 syndrome in systemic lupus erythematosus (SLE). A 28 year old woman with underlying lupus was presented with sudden left side body weakness and diplopia. Examination showed features of 16 syndrome with one and a half syndrome, facial diplegia and left hemiparesis. Neuroimaging revealed an acute infarct of bilateral dorsal pons. The patient was placed on antiplatelet therapy. However, she developed left leg deep vein thrombosis and pulmonary embolism after one week. She was then given subcutaneous low molecular weight heparin, followed by warfarin and cycles of cyclophosphamide. Her hemipa...
Source: Neurology India - October 21, 2022 Category: Neurology Authors: Masnon Nurul Ain Teo Shee Kiang Wan Hazabbah Wan Hitam Hui Jan Tan Rabani Remli Wan Zaidi Wan Asyraf Othmaliza Othman Source Type: research

Propensity of Stroke in Standard versus Various Aortic Arch Variants: A 200 Patients Study
CONCLUSIONS: Standard aortic arch Type 2, bovine aortic arch Type A, and Type B are associated with an early age at stroke presentation. During routine carotid evaluation by CT or MR angiography in stroke patients, it would be better to evaluate the aortic arch as well, especially in young patients.PMID:36211155 | PMC:PMC9540953 | DOI:10.4103/aian.aian_710_21
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Swapnil Samadhiya Vijay Sardana Bharat Bhushan Dilip Maheshwari Seeta Ram Yadav Ravi Goyal Source Type: research