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Changes in cerebral autoregulation, stroke-related blood biomarkers, and autonomic regulation after patent foramen ovale closure in severe migraine patients
CONCLUSION: Patent foramen ovale closure can improve dCA and alter elevated arterial PDGF-BB levels in migraine patients with PFO, both of which may be related to the preventive effect of PFO closure on stroke occurrence/recurrence.PMID:37157233 | DOI:10.1111/cns.14244
Source: CNS Neuroscience and Therapeutics - May 9, 2023 Category: Neuroscience Authors: Zhen-Ni Guo Yang Qu Yongsheng Gao Yingqi Xing Hongyin Ma Jia Liu Yu-Zhu Guo Junlei Chang Peng Zhang Hang Jin Xin Sun Ke Han Han-Hwa Hu Qianyan He David Martin Simpson Yi Yang Source Type: research

Stroke after spontaneous intracranial hypotension: Not a single mechanism. Case report and review of literature
We report a case of SIH followed with brain infarction, with a distinct presentation from previous literature, suggesting a different mechanism. A 35 year-old had severe orthostatic headache, responsible for prolonged bed rest. One month later, he had acute left hemiparesis secondary to stroke and right posterior cerebral artery occlusion. Stroke MRI showed arguments for intracranial hypotension (thickened meninges). He was successfully treated with intravenous rtPA thrombolysis. Headache were resolved after an epidural blood patch. A patent foramen ovale was detected. Clinical features of this description were compared w...
Source: Journal of Clinical Neuroscience - January 16, 2020 Category: Neuroscience Source Type: research

Stroke in the Young: a Global Update
AbstractPurpose of ReviewWe aim to evaluate the epidemiology, racial and gender disparity, etiology, and treatment of stroke in the younger population.Recent FindingsThe younger age group without vascular risk factors exhibits an increased prevalence of cardio-embolism in context of patent foramen ovale/atrial septal aneurysm strokes, from other determined etiology of non-atherosclerotic vasculopathy including dissection, inherited or acquired thrombophilia, and other unusual causes of stroke. Ethnic disparities also exist in certain populations.SummaryThe prevalence of stroke in the young is increasing due to several fact...
Source: Current Neurology and Neuroscience Reports - November 24, 2019 Category: Neuroscience Source Type: research

Closure of Patent Foramen Ovale and Cryptogenic Stroke: Unresolved Issues
AbstractPurpose of ReviewThis review summarises the results of randomised trials comparing closure of patent foramen ovale (PFO) with antithrombotic therapy in patients with cryptogenic stroke.Recent FindingsInitially, three randomised trials failed to show superiority of PFO closure over antithrombotic therapy in patients with cryptogenic stroke. Three recently performed trials and the prolongation of an earlier trial provided evidence that PFO closure in patients with cryptogenic stroke and an age range of 18 –60 years is superior to stroke prevention with antiplatelet therapy. PFO closure was not superior to anticoag...
Source: Current Neurology and Neuroscience Reports - October 17, 2018 Category: Neuroscience Source Type: research

Ischaemic stroke may symptomatically manifest as migraine aura
Publication date: Available online 19 July 2018Source: Journal of Clinical NeuroscienceAuthor(s): Michael J. Waters, Edmund Cheong, Jim Jannes, Timothy KleinigAbstractMigraine aura is a common stroke mimic. We hypothesised that some patients with typical migraine aura symptoms might have embolic stroke detected as the precipitant. We identified fourteen patients who presented with symptoms consistent with a clinical diagnosis of migraine aura, but demonstrated subsequent evidence of acute infarction on magnetic resonance imaging (MRI). In all patients, migraine aura symptoms were not directly attributable to the vascular l...
Source: Journal of Clinical Neuroscience - July 20, 2018 Category: Neuroscience Source Type: research

Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies.
CONCLUSIONS: In patients with cryptogenic stroke, PFO closure does appeared to be superior to medical therapy in stroke prevention, with an increased incidence of AF. Male, age <45 years, substantial residual shunt, and the history of ASA are the factors that will predict the benefit when PFO is closed. PMID: 29804325 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Chen X, Chen SD, Dong Y, Dong Q Tags: CNS Neurosci Ther Source Type: research

Migraine and Stroke: What ’s the Link? What to Do?
AbstractMigraine and stroke are common, disabling neurologic disorders, with a high socioeconomic burden. A link between them has been proposed years ago, and various theories have been proposed to explain this bidirectional relation. However, the precise causes remain unclear. We briefly summarize existing hypotheses of this correlation seeking for recommendations for stroke prevention in migraineurs, if any exist. Among the strongest suggested theories of migraine –stroke association are cortical spreading depression, endovascular dysfunction, vasoconstriction, neurogenic inflammation, hypercoagulability, increased pre...
Source: Current Neurology and Neuroscience Reports - March 9, 2017 Category: Neuroscience Source Type: research

Airplane stroke syndrome
We describe the patient, stroke, and flight characteristics. Over the study period, 131 million passengers arrived at Melbourne airport. Our centre admitted 5727 stroke patients, of whom 42 (0.73%) had flight-related strokes. Flight-related stroke patients were younger (median age 65 versus 73, p&lt;0.001), had similar stroke severity, and received intravenous thrombolysis more often than non-flight-related stroke patients. Seven patients had flight-related intracerebral haemorrhage. The aetiology of the ischaemic strokes was cardioembolic in 14/35 (40%), including seven patients with confirmed PFO, one with atrial sep...
Source: Journal of Clinical Neuroscience - February 20, 2016 Category: Neuroscience Source Type: research

Isolated asymptomatic pulmonary arteriovenous malformation presenting with ischaemic stroke
Publication date: Available online 17 February 2016 Source:Journal of Clinical Neuroscience Author(s): Kelly L. Bertram, Anoop Madan, Judith Frayne Young onset stroke is uncommon, and may be due to conditions other than traditional vascular risk factors. A 42-year-old woman with an ischaemic stroke was found to have left atrial bubble study positivity on transthoracic echocardiogram (TTE) suggestive of patent foramen ovale, however she also had low peripheral oxygen saturation. Investigation revealed an isolated pulmonary arteriovenous malformation (PAVM), visible on admission chest radiograph. This can cause embolic ...
Source: Journal of Clinical Neuroscience - February 18, 2016 Category: Neuroscience Source Type: research

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

Ischemic stroke related to an amniotic fluid embolism during labor
We report a young woman who survived multiple cerebral infarctions related to an amniotic fluid embolism (AFE) during labor. To our knowledge, an embolic stroke due to the coexistence of an AFE and patent foramen ovale (PFO) has not been reported. We describe the patient’s clinical and radiological features and discuss the stroke mechanism in relation to our AFE hypothesis. A 32-year-old woman presented to the emergency room after experiencing convulsions during labor (blood pressure, 64/28mmHg; oxygen saturation, 67%). She was in a stupor, and her response to painful stimuli on the right side was weaker than on the left...
Source: Journal of Clinical Neuroscience - February 21, 2015 Category: Neuroscience Source Type: research