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Lyme neuroborreliosis: Progressive cerebral vasculitis responsive to cyclophosphamide. A case report and review of the literature
Less than 1 % of patients with Lyme Neuroborreliosis (LNB) present with a cerebrovascular event. Ischaemic strokes occur more commonly than parenchymal or subarachnoid haemorrhages. If cerebral vasculitis due to LNB is suspected, antibiotic treatment should be started immediately, which will normally lead to remission. Very rarely progression and recurrent strokes are observed despite sufficient antibiotic therapy, even if steroids are added. Currently there are no guidelines on the adequate treatment of cerebral vasculitis due to LNB which is not responsive to antibiotics and steroids, but in very few reported cases cyclo...
Source: Journal of Stroke and Cerebrovascular Diseases - June 17, 2023 Category: Neurology Authors: D ésirée Bajons, Roman Fröhlich, Waltraud Grandits, Miroslav Krstic, Helmut Rauschka, Regina Katzenschlager Source Type: research

Lyme neuroborreliosis-associated cerebrovascular events in the Finnish endemic area
Neuroborreliosis is a rare cause of cerebral vasculitis and stroke. The incidence of Lyme borreliosis in Finland has been increasing in the last 20  years, so we expect that Lyme neuroborreliosis–associated vasculitis can be a more common cause of stroke in the future.
Source: Journal of the Neurological Sciences - June 16, 2021 Category: Neurology Authors: Maria Mironova, Elisa Kortela, Satu Kurkela, Mari Kanerva, Sami Curtze Source Type: research

Pediatric stroke related to Lyme neuroborreliosis: Data from the Swiss NeuroPaediatric Stroke Registry and literature review.
CONCLUSIONS: Lyme Neuroborreliosis accounts for a small proportion of paediatric stroke even in an endemic country. The strong predilection towards posterior cerebral circulation with clinical occurrence of brainstem signs associated with meningeal symptoms and CSF lymphocytosis are suggestive features that should rapidly point to the diagnosis. This can confirmed by appropriate serological testing in the serum and CSF. Clinicians must be aware of this rare neurological complication of Lyme disease that demands specific antibiotic treatment. PMID: 29208342 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - November 24, 2017 Category: Neurology Authors: Monteventi O, Steinlin M, Regényi M, Roulet-Perez E, Weber P, Fluss J Tags: Eur J Paediatr Neurol Source Type: research

Streptococcus pneumoniae meningitis and intracranial vasculopathy: Clinical correlation with improving transcranial Doppler hemodynamics (P1.322)
Conclusions:Antibiotic treatment for S. pneumoniae meningitis correlated with improvement in clinical status and TCD hemodynamics. Serial TCDs may be a potentially useful strategy in the management of bacterial meningitis.Disclosure: Dr. Idris has nothing to disclose. Dr. Tai has nothing to disclose. Dr. Tan has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Idris, M. I., Tai, S. M. L., Tan, C. T., Tan, K. S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Cerebral vasculitis and stroke due to Lyme neuroborreliosis: A favorable clinical outcome after early antibiotic treatment
Lyme neuroborreliosis (LNB) is a disease of the nervous system caused by the spirochete Borrelia burgdorferi sensu lato genospecies, which is transmitted by the bite of infected ticks. Approximately 15% of patients with Lyme borreliosis develop neurological manifestations; most frequently meningitis, cranial neuritis or polyradiculitis [1]. Ischemic stroke due to cerebral vasculitis is rarely (
Source: Journal of the Neurological Sciences - January 24, 2017 Category: Neurology Authors: Meinie Seelen, Ido R. van den Wijngaard, Rob S. Rundervoort Tags: Letter to the Editor Source Type: research

Stroke-like Phenomena Revealing Multifocal Cerebral Vasculitis in Pediatric Lyme Neuroborreliosis
We report a previously healthy 12-year-old boy who presented with acute left hemiparesis and meningeal signs. Neuroimaging failed to reveal any cerebral infarction but demonstrated a multifocal cerebral vasculitis involving small, medium and large-sized vessels affecting both the anterior and posterior circulation. Concentric contrast enhancement of the basilar artery was also observed. Further investigations and laboratory findings were consistent with Lyme neuroborreliosis. A rapidly favorable clinical outcome was obtained with appropriate antibiotic treatment along with antiaggregants and steroids. Lyme neuroborreliosis...
Source: Journal of Child Neurology - July 16, 2015 Category: Neurology Authors: Kurian, M., Pereira, V. M., Vargas, M. I., Fluss, J. Tags: Brief Communication Source Type: research

Correspondence Infectious causes of stroke
We read with great interest the excellent Review by Jennifer Fugate and colleagues1 about the infectious causes of stroke. Their Review is useful for daily practice, since physicians often focus excessively on autoimmune causes of central nervous system vasculitis causing stroke, while forgetting about infectious causes. However, we think that apart from neurosyphilis, which is mentioned in great detail, an additional comment on stroke caused by another spirochetal disease, Lyme neuroborreliosis, is needed.
Source: The Lancet Infectious Diseases - May 18, 2015 Category: Infectious Diseases Authors: Adam Garkowski, Joanna Zajkowska, Anna Moniuszko, Piotr Czupryna, Sławomir Pancewicz Tags: Correspondence Source Type: research

Acute Lyme Neuroborreliosis With Transient Hemiparesis and Aphasia
We report a case of a female teenager presenting with sudden-onset aphasia and transient right-sided faciobrachial hemiplegia, along with headache and agitation. Ischemia, vasculitis, or another structural lesion was excluded by brain imaging. Toxicologic evaluation results were negative. Cerebral perfusion computed tomography and electroencephalography showed left parietotemporal brain dysfunction. Lumbar puncture result, although atypical, suggested bacterial infection and intravenous ceftriaxone was initiated. Finally, microbiological cerebrospinal fluid analysis revealed Lyme neuroborreliosis, showing specific intrathe...
Source: Annals of Emergency Medicine - March 2, 2015 Category: Emergency Medicine Source Type: research

Vasculitis and stroke due to Lyme neuroborreliosis – a review
Scandinavian Journal of Infectious Diseases, Ahead of Print.
Source: Scandinavian Journal of Infectious Diseases - October 24, 2014 Category: Infectious Diseases Tags: article Source Type: research