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Association between bisphosphonate use and stroke risk: a meta-analysis
ConclusionOur results suggest that bisphosphonate use is associated with a lower risk of stroke. However, the current evidence does not lead to a definite conclusion due to the borderline statistical significance and high between-study heterogeneity. Future studies, especially RCTs, are necessary to assess causality.
Source: Osteoporosis International - May 30, 2023 Category: Orthopaedics Source Type: research

Efficacy and safety of odanacatib for osteoporosis treatment: a systematic review and meta-analysis
ConclusionODN is an appealing long-term osteoporosis treatment method; however, further research should focus on the potential increased risk of fracture and stroke.
Source: Archives of Orthopaedic and Trauma Surgery - May 11, 2023 Category: Orthopaedics Source Type: research

Osteoporotic fracture admissions compared to other major medical admissions in Irish public hospitals
ConclusionOsteoporotic fractures represent a large and rapidly increasing illness burden amongst older Irish adults, with substantial care requirements and the resulting onus on our healthcare system. Urgent action is needed to address this public health issue and the services for those at risk of fracture.
Source: Archives of Osteoporosis - December 17, 2022 Category: Orthopaedics Source Type: research

Sickle cell bone disease and response to intravenous bisphosphonates in children
ConclusionChildren with SCD have the potential for extensive and early-onset bone morbidity. In this series, IV bisphosphonates were effective for bone pain analgesia and did not trigger sickle cell complications.
Source: Osteoporosis International - July 29, 2022 Category: Orthopaedics Source Type: research

Estimating the incidence and key risk factors of cardiovascular disease in patients at high risk of imminent fracture using routinely collected real ‐world data from the UK
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - July 12, 2022 Category: Orthopaedics Authors: Marta Pineda ‐Moncusí, Leena El‐Hussein, Antonella Delmestri, Cyrus Cooper, Moayyeri Alireza, Cesar Libanati, Emese Toth, Daniel Prieto‐Alhambra, Sara Khalid Tags: Research Article Source Type: research

Incident peptic ulcers and concomitant treatment of direct oral anticoagulants and oral bisphosphonates —a real-world cohort study
ConclusionBased on our results, concomitant use of oBP and DOAC is associated with a slight increase in the risk of peptic ulcers compared to either drug alone. The prescribing physician should weigh the slight increased risk of ulcer in concomitant users of oBP and DOAC with beneficial reductions in stroke and fractures.
Source: Osteoporosis International - January 26, 2022 Category: Orthopaedics Source Type: research

Osteoporosis and the long-term risk of peripheral artery disease: a population-based longitudinal follow-up study in Taiwan
ConclusionThis study found an increased long-term risk of PAD in both men and women with osteoporosis.Mini abstractOsteoporosis has been associated with increased risks of atherosclerotic diseases. However, the relationship between osteoporosis and peripheral artery disease remains uncertain. The present population-based longitudinal follow-up study showed that patients with osteoporosis are at an increased risk of developing peripheral artery disease.
Source: Osteoporosis International - January 12, 2022 Category: Orthopaedics Source Type: research

Gait speed and spasticity are independently associated with estimated failure load in the distal tibia after stroke: an HR-pQCT study
ConclusionThe paretic distal tibia showed more compromised vBMD, cortical area, cortical thickness, and estimated failure load than the non-paretic tibia. Gait speed and spasticity were independently associated with estimated failure load. As treatment programs focusing on these potentially modifiable stroke-related impairments are feasible to administer, future studies are needed to determine the efficacy of such intervention strategies for improving bone strength in individuals with chronic stroke.
Source: Osteoporosis International - October 12, 2021 Category: Orthopaedics Source Type: research

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