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Cardiovascular risk and mortality in patients with hyperuricemia treated with febuxostat or allopurinol: a retrospective nation-wide cohort study in Austria 2014 –2017
AbstractPatients with hyperuricemia and gout are at an increased risk for cardiovascular (CV) disease. Inhibition of the xanthine oxidase with allopurinol or febuxostat have become the mainstay for urate lowering therapy. However, it has been suggested that febuxostat increases the risk for CV mortality as compared to allopurinol. The aim of this retrospective cohort study was to assess the CV risk among patients with febuxostat or allopurinol therapy. Patients who initiated urate lowering therapy with febuxostat or allopurinol between 2014 and 2017 were selected from the drug reimbursement database of the Austrian health ...
Source: Rheumatology International - May 19, 2022 Category: Rheumatology Source Type: research

Genetic liability to rheumatoid arthritis in relation to coronary artery disease and stroke risk
ConclusionThis study found that genetic liability to RA was associated with increased risk of CAD and intracerebral hemorrhage and that the association for CAD might be mediated by CRP. The heightened cardiovascular risk should be actively monitored and managed in RA patients, and this may include damping systemic inflammation.
Source: Arthritis and Rheumatology - May 18, 2022 Category: Rheumatology Authors: Shuai Yuan, Paul Carter, Amy M. Mason, Fangkun Yang, Stephen Burgess, Susanna C. Larsson Tags: Full Length Source Type: research

Primary angiitis of the central nervous system and reversible cerebral vasoconstriction syndrome: analysis of the National Inpatient Sample
ConclusionsWe performed an analysis of the NIS to better understand RCVS and PACNS hospitalizations. Severe neurologic events including CVA and SAH were elevated in both, but SAH and related hemiplegia/hemiparesis were extremely common among RCVS hospitalizations. In-hospital mortality was elevated in PACNS but not RCVS. This information can be used to help clinicians better understand, distinguish, and diagnose these conditions.Key Points•Despite clear description of RCVS and PACNS in the medical literature, there remains a scarcity of national population-based studies comparing these two entities against the general ad...
Source: Clinical Rheumatology - April 12, 2022 Category: Rheumatology Source Type: research

Antiphospholipid syndrome-mediated acute cerebrovascular diseases and long-term outcomes
CONCLUSION: We found no differences between stroke subtypes and APS types. aPL profiles were not associated with any of the acute cerebrovascular diseases described in this cohort. CVT may be an initial thrombotic manifestation of APS with low mortality and good long-term functional outcome.PMID:35042376 | DOI:10.1177/09612033221074178
Source: Lupus - January 19, 2022 Category: Rheumatology Authors: Miguel Garc ía-Grimshaw Diego Rub én Posadas-Pinto Amado Jim énez-Ruiz Sergio Iv án Valdés-Ferrer Arturo Cadena-Fern ández Jos é Jiram Torres-Ruiz Jos é Domingo Barrientos-Guerra Margarita Amancha-Gabela Erwin Chiquete Fernando Daniel Flores-Silva Source Type: research

Stroke is Different in Systemic Lupus Erythematosus: Implications for Survival and Functionality
J Rheumatol. 2021 Mar 1:jrheum.201209. doi: 10.3899/jrheum.201209. Online ahead of print.ABSTRACTUndoubtedly, individuals with systemic lupus erythematosus (SLE) are at higher risk for developing cerebrovascular disease than counterparts from the general population without SLE. In a metaanalysis of studies from around the world, the likelihood of individuals with SLE developing both ischemic and hemorrhagic stroke (intracerebral and/or subarachnoid hemorrhage) was more than 2 times that of the general population1 Risks for stroke appear to be highest soon after SLE diagnosis, and concomitant antiphospholipid syndrome (APS)...
Source: Journal of Rheumatology - March 2, 2021 Category: Rheumatology Authors: Marios Rossides Source Type: research

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