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Condition: Hemorrhagic Stroke
Nutrition: Herbs
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Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and ClinicalTrials.gov: a narrative review
CONCLUSIONS: Irregular and inadequate reporting, untimely update and publication, insufficient information on traditional medicine unique characteristics, and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases. More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials.PMID:35322645 | DOI:10.19852/j.cnki.jtcm.2022.01.010
Source: Journal of Traditional Chinese Medicine - March 24, 2022 Category: Complementary Medicine Authors: Jing-Jing Wei Rong-Juan Guo Guo-Jing Fu Xiao Liang Zhen-Min Xu Xing Liao Min Jia Zi-Xiu Zeng Wan-Qing DU Wei-Wei Jiao Lin-Juan Sun Hong-Mei Liu Chun-Li Guo Chen-Guang Tong Yun-Ling Zhang Source Type: research
Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research
Evaluating the anticoagulant effect of medicinal plants in vitro by cheminformatics methods
Conclusion In this study, the anticoagulant effect was identified as a significant property of five medicinal plants. These plants can be regarded as likely candidates for prevention and treatment of complications in individuals with high risk of stroke or ischemia. Also, we suggest that these plants should be cautiously consumed with anticoagulant drugs (e.g. heparin) due to a risk of hemorrhage and increase in the effect of anticoagulant drugs.
Source: Journal of Herbal Medicine - May 17, 2016 Category: Complementary Medicine Source Type: research
Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease
Publication date: January 2018 Source:Chinese Journal of Natural Medicines, Volume 16, Issue 1 Author(s): Xiao-Cong PANG, De KANG, Jian-Song FANG, Ying ZHAO, Lv-Jie XU, Wen-Wen LIAN, Ai-Lin LIU, Guan-Hua DU Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS formula for Alzheimer's disease (AD) only focus on single component of this prescription, and there is...
Source: Chinese Journal of Natural Medicines - February 24, 2018 Category: Complementary Medicine Source Type: research
Proteomic analysis reveals the renoprotective effect of Tribulus terrestris against obesity-related glomerulopathy in rats.
In conclusion, TT may play a protective role against ORG in rats.
PMID: 29984733 [PubMed - as supplied by publisher]
Source: Biological and Pharmaceutical Bulletin - July 6, 2018 Category: Drugs & Pharmacology Authors: Jiang YH, Jiang LY, Wu S, Jiang WJ, Xie L, Li W, Yang CH Tags: Biol Pharm Bull Source Type: research
Efficacy and Safety of Chinese Herbal Medicine for Primary Intracerebral Hemorrhage: A Systematic Review of Randomized Controlled Trials
Conclusion: The present study provided supportive evidence of CHM for improving dependency of ICH and showed generally safety; however, there is still lack of evidence for improving mortality rate, and it opens for further study.
Source: Frontiers in Pharmacology - October 9, 2019 Category: Drugs & Pharmacology Source Type: research
Repeatedly heated mix vegetable oils-induced atherosclerosis and effects of Murraya koenigii
Statins are considered as standard drugs to control cholesterol levels, but their use is also associated with renal hypertrophy, hemorrhagic stroke, hepatomegaly, and myopathy. Murraya koenigii is an herb that is...
Source: BMC Complementary and Alternative Medicine - July 14, 2020 Category: Complementary Medicine Authors: Gul Ambreen, Afshan Siddiq, Kashif Hussain, Abdul Saboor Hussain and Zara Naz Tags: Research article Source Type: research
Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology of ICH-induced brain injury is still unclear. Moreover, there is no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays a dominant role in the pathogenesis of ICH injury. Baicalin is a main active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has been reported to exhibit neuroprotective effects against ICH-induced brain injury as well as reduce iron deposition in multiple tissues. Therefore, in this ...
Source: Frontiers in Pharmacology - March 19, 2021 Category: Drugs & Pharmacology Source Type: research
Effect of Neurorepair for Motor Functional Recovery Enhanced by Total Saponins From Trillium tschonoskii Maxim. Treatment in a Rat Model of Focal Ischemia
Trillium tschonoskii Maxim. (TTM), is a perennial herb from Liliaceae, that has been widely used as a traditional Chinese medicine treating cephalgia and traumatic hemorrhage. The present work was designed to investigate whether the total saponins from Trillium tschonoskii Maxim. (TSTT) would promote brain remodeling and improve gait impairment in the chronic phase of ischemic stroke. A focal ischemic model of male Sprague-Dawley (SD) rats was established by permanent middle cerebral artery occlusion (MCAO). Six hours later, rats were intragastrically treated with TSTT (120, 60, and 30 mg/kg) and once daily up to day 30. ...
Source: Frontiers in Pharmacology - December 10, 2021 Category: Drugs & Pharmacology Source Type: research
Herb Formula (GCis) Prevents Pulmonary Infection Secondary to Intracerebral Hemorrhage by Enhancing Peripheral Immunity and Intestinal Mucosal Immune Barrier
This study provides a herb formula (GCis) that could enhance peripheral immunity and intestinal mucosal immune barrier to prevent pulmonary infection induced by ICH. It would be beneficial in the prevention of severe clinical infections.
Source: Frontiers in Pharmacology - May 23, 2022 Category: Drugs & Pharmacology Source Type: research
Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine
AbstractThromboembolism is the third leading vascular disease, with a high annual incidence of 1 to 2 cases per 1000 individuals within the general population. The broader term venous thromboembolism generally refers to deep vein thrombosis, pulmonary embolism, and/or a combination of both. Therefore, thromboembolism can affect both – the central and peripheral veins. Arterial thromboembolism causes systemic ischemia by disturbing blood flow and oxygen supply to organs, tissues, and cells causing, therefore, apoptosis and/or necrosis in the affected tissues. Currently applied antithrombotic drugs used, e.g. to protect af...
Source: EPMA Journal - August 15, 2022 Category: International Medicine & Public Health Source Type: research
